Patulin suppresses α1-adrenergic receptor expression in HEK293 cells [PDF]
Scientific Reports, 2020 AbstractPatulin (PAT) is a common mycotoxin contaminant of apple products linked to impaired metabolic and kidney function. Adenosine monophosphate activated protein kinase (AMPK), abundantly expressed in the kidney, intercedes metabolic changes and renal injury.
Pillay, Yashodani +4 more
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Latent membrane protein 1 is dispensable for Epstein-Barr virus replication in human embryonic kidney 293 cells. [PDF]
PLoS ONE, 2011 Epstein Barr Virus (EBV) replicates in oral epithelial cells and gains entry to B-lymphocytes. In B-lymphocytes, EBV expresses a restricted subset of genes, the Latency III program, which converts B-lymphocytes to proliferating lymphoblasts.
Vicki Geiser +2 more
doaj +1 more source
CD133 induces tumour-initiating properties in HEK293 cells [PDF]
Tumor Biology, 2012 The pentaspan protein CD133 (Prominin-1) is part of the signature of tumour-initiating cells for various cancer entities. The aim of the present study was to investigate the impact of ectopic CD133 expression on tumourigenic properties of otherwise CD133-negative, non-tumourigenic cells in vitro and in vivo.
Canis +8 more
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Effect of Quercetin on Injury to Indomethacin-Treated Human Embryonic Kidney 293 Cells
Life, 2021 Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat inflammation and pain and even to prevent the progression of cardiovascular disease. They have become widely used because of their effectiveness, especially among athletes performing high ...
Chun Chen +4 more
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Comparing the cytotoxic effects of iron oxide nanoparticles synthesized using the cytoplasmic extract of Lactobacillus casei and chemical synthesis [PDF]
Medical Laboratory Journal, 2023 Background: Discovering new cytotoxic compounds has received significant attention due to the rise in drug resistance and the adverse effects associated with chemotherapy drugs.
mahnoosh fatemi +3 more
doaj
Induction of TLR-2 and TLR-5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-α. [PDF]
PLoS ONE, 2011 Helicobacter pylori is the causative agent for developing gastritis, gastric ulcer, and even gastric cancer. Virulent strains carry the cag pathogenicity island (cagPAI) encoding a type-IV secretion system (T4SS) for injecting the CagA protein.
Suneesh Kumar Pachathundikandi +3 more
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Human concentrative nucleoside transporter 3 transfection with ultrasound and microbubbles in nucleoside transport deficient HEK293 cells greatly increases gemcitabine uptake. [PDF]
PLoS ONE, 2013 Gemcitabine is a hydrophilic clinical anticancer drug that requires nucleoside transporters to cross plasma membranes and enter cells. Pancreatic adenocarcinomas with low levels of nucleoside transporters are generally resistant to gemcitabine and are ...
Robert J Paproski +6 more
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Acta Virologica, 2023 Human adenovirus-5 (hAd5) is an important gene delivery vector, which has been widely used in various fields of biomedicine, such as gene therapy, cancer therapy, and vaccine development.
Wenbo Xie +4 more
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BK Polyomavirus Activates HSF1 Stimulating Human Kidney Hek293 Cell Proliferation [PDF]
Oxidative Medicine and Cellular Longevity, 2021 Objectives. Some DNA viruses, such as BKPyV, are capable of inducing neoplastic transformation in human tissues through still unclear mechanisms. The goal of this study is to investigate the carcinogenic potential of BK polyomavirus (BKPyV) in human embryonic kidney 293 (Hek293) cells, dissecting the molecular mechanism that determines the neoplastic ...
Baldelli S +7 more
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Characterization of amiodarone action on currents in hERG-T618 gain-of-function mutations
Open Life Sciences, 2023 Ami (10 μM) had a greater retarding effect on the hERG-T618I channel than WT (P < 0.05). The half-inhibitory concentration for the mutant (4.56 μM) was approximately 1.82 times that of WT (2.51 μM).
Lin Min +5 more
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