Results 111 to 120 of about 191,259 (287)
Structure of the eukaryotic replicative CMG helicase and pumpjack motion
Nature Structural &Molecular Biology, 2016 The CMG helicase is composed of Cdc45, Mcm2–7 and GINS. Here we report the structure of the Saccharomyces cerevisiae CMG, determined by cryo-EM at a resolution of 3.7–4.8 Å.
Zuanning Yuan +6 more
semanticscholar +1 more source
Frontiers in Bioscience, 2012 Superfamily 2 helicases are involved in all aspects of RNA metabolism, and many steps in DNA metabolism. This review focuses on the basic mechanistic, structural and biological properties of each of the families of helicases within superfamily 2. There are ten separate families of helicases within superfamily 2, each playing specific roles in nucleic
Kevin D. Raney, Alicia K. Byrd
openaire +3 more sources
Protein signatures using electrostatic molecular surfaces in harmonic space
, 2013 We developed a novel method based on the Fourier analysis of protein molecular surfaces to speed up the analysis of the vast structural data generated in the post-genomic era.
Carvalho, C. Sofia +4 more
core +2 more sources
DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster [PDF]
Nucleic Acids Research, 2012 Conserved Iron-Sulfur (Fe-S) clusters are found in a growing family of metalloproteins that are implicated in prokaryotic and eukaryotic DNA replication and repair. Among these are DNA helicase and helicase-nuclease enzymes that preserve chromosomal stability and are genetically linked to diseases characterized by DNA repair defects and/or a poor ...
Robert M. Brosh, Yuliang Wu
openaire +3 more sources
, 2011 Three, interrelated biologically-relevant examples of biased random walks are presented: (1) A model for DNA melting, modelled as DNA unzipping, which provides a way to illustrate the role of the Boltzmann factor in a venue well-known to biology and pre ...
Feynman R. P. +5 more
core +1 more source
Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability [PDF]
, 2018 R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become pathological
Aguilera López, Andrés +2 more
core +1 more source
The ATPase cycle of PcrA helicase and its coupling to translocation on DNA. [PDF]
, 2009 The superfamily 1 bacterial helicase PcrA has a role in the replication of certain plasmids, acting with the initiator protein (RepD) that binds to and nicks the double-stranded origin of replication.
Martinez-Senac, Maria M +3 more
core +1 more source
eLife, 2017 Replicative helicases are ring-shaped hexamers that encircle DNA for duplex unwinding. The currently accepted view of hexameric helicase function is by steric exclusion, where the helicase encircles one DNA strand and excludes the other, acting as a ...
Lance D. Langston, M. O’Donnell
semanticscholar +1 more source
Accelerated epigenetic aging in Werner syndrome. [PDF]
, 2017 Individuals suffering from Werner syndrome (WS) exhibit many clinical signs of accelerated aging. While the underlying constitutional mutation leads to accelerated rates of DNA damage, it is not yet known whether WS is also associated with an increased ...
Flunkert, Julia +5 more
core +1 more source
Arabidopsis RecQl4A suppresses homologous recombination and modulates DNA damage responses [PDF]
, 2005 The DNA damage response and DNA recombination are two interrelated mechanisms involved in maintaining the integrity of the genome, but in plants they are poorly understood.
Bachrati +64 more
core +3 more sources