Results 141 to 150 of about 191,259 (287)

Research Progress on the NSP10 Protein of Porcine Reproductive and Respiratory Syndrome Virus

Microorganisms
Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious and pathogenic infectious disease caused by the porcine reproductive and respiratory syndrome virus (PRRSV).
Gan Li, Yajie Zheng, Qin Luo, Yaohua Liang, Hang Zhang, Huiyang Sha, Ruining Wang, Weili Kong, Mengmeng Zhao   +8 more
doaj   +1 more source

Multiple kinases inhibit origin licensing and helicase activation to ensure reductive cell division during meiosis

eLife, 2018
Meiotic cells undergo a single round of DNA replication followed by two rounds of chromosome segregation (the meiotic divisions) to produce haploid gametes.
David V Phizicky, Luke E Berchowitz, Stephen P Bell   +2 more
doaj   +1 more source

A fluorescence-based helicase assay: application to the screening of G-quadruplex ligands

Nucleic Acids Research, 2015
Helicases, enzymes that unwind DNA or RNA structure, are present in the cell nucleus and in the mitochondrion. Although the majority of the helicases unwind DNA or RNA duplexes, some of these proteins are known to resolve unusual structures such as G ...
O. Mendoza, N. M. Gueddouda, J. Boulé, A. Bourdoncle, J. Mergny   +4 more
semanticscholar   +1 more source

Helicase and Polymerase Move Together Close to the Fork Junction and Copy DNA in One-Nucleotide Steps

Cell Reports, 2014
By simultaneously measuring DNA synthesis and dNTP hydrolysis, we show that T7 DNA polymerase and T7 gp4 helicase move in sync during leading-strand synthesis, taking one-nucleotide steps and hydrolyzing one dNTP per base-pair unwound/copied.
Manjula Pandey, Smita S. Patel
doaj   +1 more source

Switch on the engine: how the eukaryotic replicative helicase MCM2–7 becomes activated

Chromosoma, 2015
A crucial step during eukaryotic initiation of DNA replication is the correct loading and activation of the replicative DNA helicase, which ensures that each replication origin fires only once.
Silvia Tognetti, A. Riera, C. Speck
semanticscholar   +1 more source

Novel Tetrazolium-Based Colorimetric Assay for Helicase nsp13 in SARS-CoV-2

BioChem
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a human pathogenic virus that encodes for a helicase (SC2Hel) that is essential for viral replication. SC2Hel has the ability to unravel dsRNA or dsDNA in an NTP-dependent manner from the 5′
Triet M. Pham, Morgan G. Howard, Shane M. Carey, Lindsey R. Baker, Edward L. D’Antonio   +4 more
doaj   +1 more source

ATP-Stimulated, DNA-Mediated Redox Signaling by XPD, a DNA Repair and Transcription Helicase [PDF]

, 2011
Using DNA-modified electrodes, we show DNA-mediated signaling by XPD, a helicase that contains a [4Fe-4S] cluster and is critical for nucleotide excision repair and transcription.
Barton, Jacqueline K., Fuss, Jill O., Ishida, Justin P., Mui, Timothy P., Tainer, John A.   +4 more
core   +1 more source

Disease Mechanisms and Therapeutic Approaches in SMARD1—Insights from Animal Models and Cell Models

Biomedicines
Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a fatal childhood motoneuron disease caused by mutations in the IGHMBP2 gene. It is characterized by muscle weakness, initially affecting the distal extremities due to the degeneration ...
Sibylle Jablonka, Ezgi Yildirim
doaj   +1 more source

Enlarged family of putative helicases [PDF]

, 1988
David P. Lane
openalex   +1 more source

Semidominant suppressors of Srs2 helicase mutations of Saccharomyces cerevisiae map in the RAD51 gene, whose sequence predicts a protein with similarities to procaryotic RecA proteins. [PDF]

, 1992
A Aboussekhra, R. Chanet, A Adjiri, Francis Fabre   +3 more
openalex   +1 more source