Results 11 to 20 of about 215,192 (350)
Therapeutic potential of compounds targeting SARS-CoV-2 helicase
Frontiers in Chemistry, 2022 The economical and societal impact of COVID-19 has made the development of vaccines and drugs to combat SARS-CoV-2 infection a priority. While the SARS-CoV-2 spike protein has been widely explored as a drug target, the SARS-CoV-2 helicase (nsp13) does ...
Matthew T. J. Halma +6 more
doaj +1 more source
bioRxiv, 2020 SARS-CoV-2 is the causative agent of the 2019-2020 pandemic. The SARS-CoV-2 genome is replicated-transcribed by the RNA-dependent RNA polymerase holoenzyme (subunits nsp7/nsp82/nsp12) along with a cast of accessory factors.
James Chen +12 more
semanticscholar +1 more source
A helicase-tethered ORC flip enables bidirectional helicase loading [PDF]
eLife, 2021 Replication origins are licensed by loading two Mcm2-7 helicases around DNA in a head-to-head conformation poised to initiate bidirectional replication. This process requires origin–recognition complex (ORC), Cdc6, and Cdt1. Although different Cdc6 and Cdt1 molecules load each helicase, whether two ORC proteins are required is unclear.
Shalini Gupta +3 more
openaire +4 more sources
The enigmatic helicase DHX9 and its association with the hallmarks of cancer
Future Science OA, 2021 Much interest has been expended lately in characterizing the association between DExH-Box helicase 9 (DHX9) dysregulation and malignant development, however, the enigmatic nature of DHX9 has caused conflict as to whether it regularly functions as an ...
Chloe Gulliver +2 more
doaj +1 more source
Virologica Sinica, 2020 The ongoing outbreak of Coronavirus Disease 2019 (COVID-19) has become a global public health emergency. SARS-coronavirus-2 (SARS-CoV-2), the causative pathogen of COVID-19, is a positive-sense single-stranded RNA virus belonging to the family ...
T. Shu +10 more
semanticscholar +1 more source
Microorganisms, 2020 Brucellosis is still a global health issue, and surveillance and control of this zoonotic disease in livestock remains a challenge. Human outbreaks are mainly linked to the consumption of unpasteurized dairy products.
Michaela Projahn +3 more
doaj +1 more source
Discovery of COVID-19 Inhibitors Targeting the SARS-CoV-2 Nsp13 Helicase
Journal of Physical Chemistry Letters, 2020 The raging COVID-19 pandemic caused by SARS-CoV-2 has infected tens of millions of people and killed several hundred thousand patients worldwide. Currently, there are no effective drugs or vaccines available for treating coronavirus infections.
M. A. White, Wei Lin, Xiaodong Cheng
semanticscholar +1 more source
European Journal of Biology, 2022 Objective: Coronavirus Disease 2019 (COVID19) is a viral disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2). The high mutation propensity of the SARS CoV-2 genome is one of the biggest threats to the long-term validity of ...
Ekrem Akbulut
doaj +1 more source
Frontiers in Microbiology, 2018 Chromosomal replication initiation requires dynamic mechanisms in higher-order nucleoprotein complexes that are constructed at the origin of replication.
Yukari Sakiyama +5 more
doaj +1 more source
The Nuclease Activity of the Yeast Dna2 Protein, Which Is Related to the RecB-like Nucleases, Is Essential in Vivo [PDF]
, 2000 Saccharomyces cerevisiae Dna2 protein is required for DNA replication and repair and is associated with multiple biochemical activities: DNA-dependent ATPase, DNA helicase, and DNA nuclease.
Budd, Martin E. +2 more
core +1 more source