Results 11 to 20 of about 191,259 (287)
BIO-PROTOCOL, 2014 Helicases are a class of enzymes which are motor proteins using energy derived from ATP hydrolysis to move directionally along a nucliec acid phosphodiester backbone (such as DNA, RNA and DNA-RNA hybrids) and separate two annealed nucleic acid strands. Many cellular processes, such as transcription, DNA replication, recombination and DNA repair involve
Xin Wang +3 more
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Ribosome as a Translocase and Helicase [PDF]
Biochemistry (Moscow), 2021 During protein synthesis, ribosome moves along mRNA to decode one codon after the other. Ribosome translocation is induced by a universally conserved protein, elongation factor G (EF-G) in bacteria and elongation factor 2 (EF-2) in eukaryotes. EF-G-induced translocation results in unwinding of the intramolecular secondary structures of mRNA by three ...
Dmitri N. Ermolenko, Chen Bao
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A helicase-tethered ORC flip enables bidirectional helicase loading [PDF]
eLife, 2021 Replication origins are licensed by loading two Mcm2-7 helicases around DNA in a head-to-head conformation poised to initiate bidirectional replication. This process requires origin–recognition complex (ORC), Cdc6, and Cdt1. Although different Cdc6 and Cdt1 molecules load each helicase, whether two ORC proteins are required is unclear.
Shalini Gupta +3 more
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bioRxiv, 2020 SARS-CoV-2 is the causative agent of the 2019-2020 pandemic. The SARS-CoV-2 genome is replicated-transcribed by the RNA-dependent RNA polymerase holoenzyme (subunits nsp7/nsp82/nsp12) along with a cast of accessory factors.
James Chen +12 more
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The enigmatic helicase DHX9 and its association with the hallmarks of cancer
Future Science OA, 2021 Much interest has been expended lately in characterizing the association between DExH-Box helicase 9 (DHX9) dysregulation and malignant development, however, the enigmatic nature of DHX9 has caused conflict as to whether it regularly functions as an ...
Chloe Gulliver +2 more
doaj +1 more source
ATPase cycle and DNA unwinding kinetics of RecG helicase [PDF]
, 2012 The superfamily 2 bacterial helicase, RecG, is a monomeric enzyme with a role in DNA repair by reversing stalled replication forks. The helicase must act specifically and rapidly to prevent replication fork collapse. We have shown that RecG binds tightly
Powell, Ben +2 more
core +17 more sources
Virologica Sinica, 2020 The ongoing outbreak of Coronavirus Disease 2019 (COVID-19) has become a global public health emergency. SARS-coronavirus-2 (SARS-CoV-2), the causative pathogen of COVID-19, is a positive-sense single-stranded RNA virus belonging to the family ...
T. Shu +10 more
semanticscholar +1 more source
History of DNA Helicases [PDF]
Genes, 2020 Since the discovery of the DNA double helix, there has been a fascination in understanding the molecular mechanisms and cellular processes that account for: (i) the transmission of genetic information from one generation to the next and (ii) the remarkable stability of the genome.
Robert M. Brosh, Steven W. Matson
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Discovery of COVID-19 Inhibitors Targeting the SARS-CoV-2 Nsp13 Helicase
Journal of Physical Chemistry Letters, 2020 The raging COVID-19 pandemic caused by SARS-CoV-2 has infected tens of millions of people and killed several hundred thousand patients worldwide. Currently, there are no effective drugs or vaccines available for treating coronavirus infections.
M. A. White, Wei Lin, Xiaodong Cheng
semanticscholar +1 more source
RNA helicases in bacteria [PDF]
Current Opinion in Microbiology, 2016 RNA plays a crucial role in the control of bacterial gene expression, either as carrier of information or as positive or negative regulators. Moreover, the machinery to decode the information, the ribosome, is a large ribonucleoprotein complex composed of rRNAs and many proteins.
Khemici Vanessa, Linder Patrick
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