Results 11 to 20 of about 194,742 (384)
BIO-PROTOCOL, 2014 Helicases are a class of enzymes which are motor proteins using energy derived from ATP hydrolysis to move directionally along a nucliec acid phosphodiester backbone (such as DNA, RNA and DNA-RNA hybrids) and separate two annealed nucleic acid strands. Many cellular processes, such as transcription, DNA replication, recombination and DNA repair involve
Xin Wang +3 more
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Ribosome as a Translocase and Helicase [PDF]
Biochemistry (Moscow), 2021 During protein synthesis, ribosome moves along mRNA to decode one codon after the other. Ribosome translocation is induced by a universally conserved protein, elongation factor G (EF-G) in bacteria and elongation factor 2 (EF-2) in eukaryotes. EF-G-induced translocation results in unwinding of the intramolecular secondary structures of mRNA by three ...
Dmitri N. Ermolenko, Chen Bao
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Interplay of Mre11 Nuclease with Dna2 plus Sgs1 in Rad51-Dependent Recombinational Repair [PDF]
, 2009 The Mre11/Rad50/Xrs2 complex initiates IR repair by binding to the end of a double-strand break, resulting in 5′ to 3′ exonuclease degradation creating a single-stranded 3′ overhang competent for strand invasion into the unbroken chromosome. The nuclease(
AS Ivessa +54 more
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A helicase-tethered ORC flip enables bidirectional helicase loading [PDF]
eLife, 2021 Replication origins are licensed by loading two Mcm2-7 helicases around DNA in a head-to-head conformation poised to initiate bidirectional replication. This process requires origin–recognition complex (ORC), Cdc6, and Cdt1. Although different Cdc6 and Cdt1 molecules load each helicase, whether two ORC proteins are required is unclear.
Shalini Gupta +3 more
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bioRxiv, 2020 SARS-CoV-2 is the causative agent of the 2019-2020 pandemic. The SARS-CoV-2 genome is replicated-transcribed by the RNA-dependent RNA polymerase holoenzyme (subunits nsp7/nsp82/nsp12) along with a cast of accessory factors.
James Chen +12 more
semanticscholar +1 more source
Virologica Sinica, 2020 The ongoing outbreak of Coronavirus Disease 2019 (COVID-19) has become a global public health emergency. SARS-coronavirus-2 (SARS-CoV-2), the causative pathogen of COVID-19, is a positive-sense single-stranded RNA virus belonging to the family ...
T. Shu +10 more
semanticscholar +1 more source
History of DNA Helicases [PDF]
Genes, 2020 Since the discovery of the DNA double helix, there has been a fascination in understanding the molecular mechanisms and cellular processes that account for: (i) the transmission of genetic information from one generation to the next and (ii) the remarkable stability of the genome.
Robert M. Brosh, Steven W. Matson
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Therapeutic potential of compounds targeting SARS-CoV-2 helicase
Frontiers in Chemistry, 2022 The economical and societal impact of COVID-19 has made the development of vaccines and drugs to combat SARS-CoV-2 infection a priority. While the SARS-CoV-2 spike protein has been widely explored as a drug target, the SARS-CoV-2 helicase (nsp13) does ...
Matthew T. J. Halma +6 more
doaj +1 more source
Discovery of COVID-19 Inhibitors Targeting the SARS-CoV-2 Nsp13 Helicase
Journal of Physical Chemistry Letters, 2020 The raging COVID-19 pandemic caused by SARS-CoV-2 has infected tens of millions of people and killed several hundred thousand patients worldwide. Currently, there are no effective drugs or vaccines available for treating coronavirus infections.
M. A. White, Wei Lin, Xiaodong Cheng
semanticscholar +1 more source
RNA helicases in bacteria [PDF]
Current Opinion in Microbiology, 2016 RNA plays a crucial role in the control of bacterial gene expression, either as carrier of information or as positive or negative regulators. Moreover, the machinery to decode the information, the ribosome, is a large ribonucleoprotein complex composed of rRNAs and many proteins.
Khemici Vanessa, Linder Patrick
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