Results 71 to 80 of about 194,742 (384)

RNA helicases in splicing [PDF]

RNA Biology, 2013
In eukaryotic cells, introns are spliced from pre-mRNAs by the spliceosome. Both the composition and the structure of the spliceosome are highly dynamic, and eight DExD/H RNA helicases play essential roles in controlling conformational rearrangements. There is evidence that the various helicases are functionally and physically connected with each other
Jean D. Beggs, Olivier Cordin
openaire   +3 more sources

DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2 [PDF]

, 2010
The repair of DNA double-strand breaks (DSBs) by homologous recombination requires processing of broken ends. For repair to start, the DSB must first be resected to generate a 3′-single-stranded DNA (ssDNA) overhang, which becomes a substrate for the DNA
AV Nimonkar, B Llorente, BO Krogh, C Zierhut, DG Anderson, E Alani, E Hartsuiker, Elda Cannavo, EP Mimitou, FG Harmon, HI Kao, I Chiolo, J LeBowitz, JA Cobb, JA Solinger, JR Mullen, Judith L. Campbell, KH Bae, L Wu, M Chang, ME Budd, ME Budd, ME Budd, MJ Neale, MS Dillingham, N Handa, P Cejka, P Szankasi, Petr Cejka, Piotr Polaczek, S Gangloff, S Gravel, SH Bae, SH Bae, Stephen C. Kowalczykowski, Subhash Pokharel, T Masuda-Sasa, Taro Masuda-Sasa, TH Stracker, X Li, Z Zhu   +40 more
core   +4 more sources

Crystal structure of Middle East respiratory syndrome coronavirus helicase

PLoS Pathogens, 2017
Middle East respiratory syndrome coronavirus (MERS-CoV) remains a threat to public health worldwide; however, effective vaccine or drug against CoVs remains unavailable. CoV helicase is one of the three evolutionary most conserved proteins in nidoviruses,
W. Hao, J. Wojdyla, R. Zhao, Ruiyun Han, Rajat S Das, Ivan Zlatev, M. Manoharan, Meitian Wang, S. Cui   +8 more
semanticscholar   +1 more source

Homologous Recombination: To Fork and Beyond [PDF]

, 2018
Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the replication forks. Cells need to tolerate many of these blocking lesions to timely complete DNA replication, postponing their repair ...
Prado Velasco, José Félix
core   +1 more source

Nuclear DDX3 expression predicts poor outcome in colorectal and breast cancer [PDF]

, 2017
Purpose: DEAD box protein 3 (DDX3) is an RNA helicase with oncogenic properties that shuttles between the cytoplasm and nucleus. The majority of DDX3 is found in the cytoplasm, but a subset of tumors has distinct nuclear DDX3 localization of yet unknown ...
Bol, Guus M., Buerger, Horst, Heerman van Voss, Marise R., Meeldijk, Jan, Offerhaus, G. Johan, Patel, Arvind H., Raman, Ana, Raman, Venu, van der Wall, Elsken, van Diest, Paul J., Vesuna, Farhad   +10 more
core   +6 more sources

Biochemical characterization of Plasmodium falciparum parasite specific helicase 1 (PfPSH1)

FEBS Open Bio, 2019
Malaria, a disease caused by infection with parasites of the genus Plasmodium, causes millions of deaths worldwide annually. Of the five Plasmodium species that can infect humans, Plasmodium falciparum causes the most serious parasitic infection.
Manish Chauhan, Suman Sourabh, Rahena Yasmin, Isha Pahuja, Renu Tuteja   +4 more
doaj   +1 more source

Structural basis of TFIIH activation for nucleotide excision repair. [PDF]

, 2019
Nucleotide excision repair (NER) is the major DNA repair pathway that removes UV-induced and bulky DNA lesions. There is currently no structure of NER intermediates, which form around the large multisubunit transcription factor IIH (TFIIH).
Chernev, A., Cramer, P., Dienemann, C., Kokic, G., Tegunov, D., Urlaub, H.   +5 more
core   +2 more sources

Dna2 is a structure-specific nuclease, with affinity for 5'-flap intermediates [PDF]

, 2010
Dna2 is a nuclease/helicase with proposed roles in DNA replication, double-strand break repair and telomere maintenance. For each role Dna2 is proposed to process DNA substrates with a 5'-flap.
Aguilera, Ayyagari, Bae, Bae, Bae, Balakrishnan, Bell, Bonetti, Budd, Budd, Budd, Budd, Budd, Budd, Ceska, Chapados, Dervan, Devos, Duxin, Garg, Harrington, Hohl, Hosfield, Jason A. Stewart, Judith L. Campbell, Kao, Kao, Kao, Kim, Kim, Lee, Liao, Liu, Liu, Liu, Masuda-Sasa, Masuda-Sasa, Mathews, Moser, Mueser, Murante, Qiu, Robert A. Bambara, Robertson, Shrader, Stewart, Stewart, Stewart, Szczesny, Weitao, Williams, Xu, Zheng, Zhu, Zuker   +54 more
core   +2 more sources

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways

Nature Communications, 2018
Mutations in BLM in Bloom Syndrome patients predispose them to multiple types of cancers. Here we report that BLM is recruited in a biphasic manner to annotated DSBs. BLM recruitment is dependent on the presence of NBS1, MRE11 and ATM. While ATM activity
V. Tripathi, Himanshi Agarwal, S. Priya, Harish Batra, Priyanka Modi, Monica Pandey, Dhurjhoti Saha, S. Raghavan, S. Sengupta   +8 more
semanticscholar   +1 more source