Results 71 to 80 of about 191,259 (287)
eLife, 2019 DNA replication requires that the duplex genomic DNA strands be separated; a function that is implemented by ring-shaped hexameric helicases in all Domains.
Himasha M Perera, Michael A Trakselis
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Microbiology Spectrum, 2023 Kaposi’s sarcoma-associated herpesvirus (KSHV) encodes six highly conserved core replication proteins essential for the viral lytic DNA synthesis, including ORF6 (single-stranded DNA-binding protein), ORF9 (DNA polymerase), ORF40/41 (primase-associated ...
Lee-Wen Chen +7 more
doaj +1 more source
Zika virus NS3 is a canonical RNA helicase stimulated by NS5 RNA polymerase
Nucleic Acids Research, 2019 Zika virus is a positive single-strand RNA virus whose replication involved RNA unwinding and synthesis. ZIKV NS3 contains a helicase domain, but its enzymatic activity is not fully characterized. Here, we established a dsRNA unwinding assay based on the
Shanshan Xu +7 more
semanticscholar +1 more source
Dynamics and Conformations of a Full-Length CRESS-DNA Replicase
Viruses, 2023 Circular Rep-encoding single-stranded DNA (CRESS-DNA) viruses encode for a Replicase (Rep) that is essential for viral replication. Rep is a helicase with three domains: an endonuclease, an oligomeric, and an ATPase domain (ED, OD, and AD).
Elvira Tarasova, Reza Khayat
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Crystal structure of Middle East respiratory syndrome coronavirus helicase
PLoS Pathogens, 2017 Middle East respiratory syndrome coronavirus (MERS-CoV) remains a threat to public health worldwide; however, effective vaccine or drug against CoVs remains unavailable. CoV helicase is one of the three evolutionary most conserved proteins in nidoviruses,
W. Hao +8 more
semanticscholar +1 more source
Snf2 family ATPases and DExx box helicases:differences and unifying concepts from high-resolution crystal structures [PDF]
, 2006 Proteins with sequence similarity to the yeast Snf2 protein form a large family of ATPases that act to alter the structure of a diverse range of DNA–protein structures including chromatin. Snf2 family enzymes are related in sequence to DExx box helicases,
Aasland +95 more
core +3 more sources
MCM2–7-dependent cohesin loading during S phase promotes sister-chromatid cohesion
eLife, 2018 DNA replication transforms cohesin rings dynamically associated with chromatin into the cohesive form to establish sister-chromatid cohesion. Here, we show that, in human cells, cohesin loading onto chromosomes during early S phase requires the ...
Ge Zheng +3 more
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Structural insights into the nucleic acid remodeling mechanisms of the yeast THO-Sub2 complex
eLife, 2020 The yeast THO complex is recruited to active genes and interacts with the RNA-dependent ATPase Sub2 to facilitate the formation of mature export-competent messenger ribonucleoprotein particles and to prevent the co-transcriptional formation of RNA:DNA ...
Sandra K Schuller +6 more
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The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity
PLoS Pathogens, 2018 DExD/H box RNA helicases, such as the RIG-I-like receptors (RLR), are important components of the innate immune system. Here we demonstrate a pivotal and sex-specific role for the heterosomal isoforms of the DEAD box RNA helicase DDX3 in the immune ...
Daniel Szappanos +14 more
semanticscholar +1 more source
eLife, 2014 The Cdc45/Mcm2-7/GINS (CMG) helicase separates DNA strands during replication in eukaryotes. How the CMG is assembled and engages DNA substrates remains unclear.
Alessandro Costa +9 more
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