Results 51 to 60 of about 84,776 (346)

Vutrisiran Improves Survival and Reduces Cardiovascular Events in ATTR Amyloid Cardiomyopathy: HELIOS-B.

Journal of the American College of Cardiology
BACKGROUND Patients with transthyretin amyloidosis with cardiomyopathy (ATTR-CM) have high mortality and morbidity. Vutrisiran, a subcutaneous RNA interference therapeutic, reduced the composite of all-cause mortality (ACM) and cardiovascular (CV) events
R. Witteles, P. García-Pavía, T. Damy, M. Grogan, F. Sheikh, C. Morbach, S. Bender, J. Exter, S. Eraly, Marianna Fontana   +9 more
semanticscholar   +1 more source

Foxp3+Helios+ regulatory T cells are associated with monocyte subsets and their PD-1 expression during acute HIV-1 infection

BMC Immunology, 2019
Background Helios has been reported to stabilize regulatory T (Treg) suppressive function. Programmed cell death protein 1 (PD-1) expression in three human monocyte subsets modulates immune responses.
Lifeng Liu, Qiuyue Zhang, Peng Chen, Na Guo, Aixin Song, Xiaojie Huang, Wei Xia, Li Li, Christiane Moog, Hao Wu, Bin Su, Tong Zhang   +11 more
doaj   +1 more source

Correlations between Circulating and Tumor-Infiltrating CD4⁺ Treg Subsets with Immune Checkpoints in Colorectal Cancer Patients with Early and Advanced Stages

Vaccines, 2022
The existence of various T regulatory cell (Treg) subsets in colorectal cancer (CRC) could play a variety of functions in the regulation of anti-cancer immunity.
Mohammad A. Al-Mterin, Khaled Murshed, Eyad Elkord   +2 more
doaj   +1 more source

Effects of vutrisiran on cardiac structure and function in patients with transthyretin amyloidosis with cardiomyopathy: secondary outcomes of the HELIOS-B trial

Nature Medicine
In the HELIOS-B randomized clinical trial, the RNA interference therapeutic agent vutrisiran reduced the risk of all-cause mortality and recurrent cardiovascular events among patients with transthyretin amyloidosis with cardiomyopathy (ATTR-CM).
K. Jering, Marianna Fontana, O. Lairez, S. Longhi, O. Azevedo, C. Morbach, S. Bender, P. Jay, J. Vest, B. Bulwer, N. Prasad, S. Solomon, H. Skali   +12 more
semanticscholar   +1 more source

Virtual LiDAR Simulation as a High Performance Computing Challenge: Toward HPC HELIOS++

IEEE Access, 2022
The software HELIOS++ simulates the laser scanning of a given virtual scene that can be composed of different spatial primitives and 3D meshes with distinct granularity.
Alberto M. Esmorís, Miguel Yermo, Hannah Weiser, L. Winiwarter, B. Höfle, F. F. Rivera   +5 more
semanticscholar   +1 more source

Tyana (Kemerhisar) Teritoryumu’ndan Yazıtlı ve Helios Büstlü Yeni Bir Sunak / A New Altar with an Inscription and Bust of Helios from the Territory of Tyana (Kemerhisar)

Arkhaia Anatolika
This contribution introduces a new inscribed altar bearing a bust of Helios, which was discovered in 2024 at the village of Kaynarca, in the Bor district of Niğde province, in the Cappadocia region.
Ramazan ÇOBAN
doaj   +1 more source

Redirecting the neo-substrate specificity of Cereblon-targeting PROTACs to Helios

ACS Chemical Biology, 2022
Immunomodulatory imide drugs (IMiDs), such as thalidomide and its analogues, are some of the most commonly utilized E3 ligase ligands for the development of proteolysis targeting chimeras (PROTACs).
Alyssa L. Verano, Inchul You, K. Donovan, Nada Mageed, Hong Yue, Radosław P. Nowak, E. Fischer, Eric S. Wang, N. Gray   +8 more
semanticscholar   +1 more source

Coronal Electron Temperature Inferred from the Strahl Electrons in the Inner Heliosphere: Parker Solar Probe and Helios Observations [PDF]

Astrophysical Journal, 2020
The shape of the electron velocity distribution function plays an important role in the dynamics of the solar wind acceleration. Electrons are normally modeled with three components, the core, the halo, and the strahl.
L. Berčič, D. Larson, P. Whittlesey, M. Maksimović, S. Badman, S. Landi, L. Matteini, S. Bale, J. Bonnell, A. Case, Thierry Dudok de Wit, K. Goetz, P. Harvey, J. Kasper, K. Korreck, R. Livi, R. Macdowall, D. Malaspina, M. Pulupa, M. Stevens   +19 more
semanticscholar   +1 more source

La villa romana La Olmeda y su Museo monográfico [PDF]

Boletín del Museo Arqueológico Nacional, 2017
La Olmeda es una de las principales villas bajoimperiales de Hispania, con más de 1400 m2 de mosaicos, destacando el mosaico del oecus con el tema de la estancia de Aquiles en Skyros. Entre los objetos encontrados merecen citarse la colección de vidrios,
José-Antonio Abásolo, Rafael Martínez
doaj  

A novel biodegradable polymer-coated sirolimus-eluting stent: 1-year results of the HELIOS registry

Chinese Medical Journal, 2023
. Background:. The HELIOS stent is a sirolimus-eluting stent with a biodegradable polymer and titanium oxide film as the tie-layer. The study aimed to evaluate the safety and efficacy of HELIOS stent in a real-world setting. Methods:. The HELIOS registry
Bo Zheng, Yi Liu, Ruining Zhang, Wangwei Yang, Fangju Su, Rutao Wang, Dapeng Chen, Guidong Shen, Yumin Qiu, Lianmin Wang, Chang Chen, Zhongwei Wu, Fei Li, Jiayi Li, Chengxiang Li, Chao Gao, Ling Tao, for the HELIOS Investigators, Yanjie Yin, Xiuyuan Hao   +19 more
doaj   +1 more source