Results 61 to 70 of about 452,289 (289)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Leveraging ribosomal RNA as a molecular target for vaccine development against Acinetobacter baumannii

Future Journal of Pharmaceutical Sciences
Background Acinetobacter baumannii, a nosocomial pathogen, has emerged as a major clinical threat due to its ability to resist a broad range of antibiotics, contributing to the increased morbidity and mortality in hospital settings.
Elijah Kolawole Oladipo, Glory Jesudara Oluwasanya, Esther Oluwadarasimi Adaramola, Gbemisola Omolara Morawo, Blessing Jephthah Oluwalemu, Victor Oluwatobi Afolabi, Praise Akanni, Joel Damilare Ajagbe, Oluwadara Hannah Ojo, Fikayo Deborah Olayiwola, Shalom Busayo Akintola, Chris Olamide Balogun, Emmanuel Pelumi Kolapo, Ayomiposi Isaiah Oshoneye, Stephen Feranmi Adeyemo, Boluwatife Ayobami Irewolede, Bamidele Abiodun Iwalokun, Oluwatosin Akinola Ajibade, Olatunji Matthew Kolawole, Olubukola Monisola Oyawoye, Julius Kola Oloke, Helen Onyeaka   +21 more
doaj   +1 more source

Utilizing Immunoinformatics for mRNA Vaccine Design against Influenza D Virus

BioMedInformatics
Background: Influenza D Virus (IDV) presents a possible threat to animal and human health, necessitating the development of effective vaccines. Although no human illness linked to IDV has been reported, the possibility of human susceptibility to ...
Elijah Kolawole Oladipo, Stephen Feranmi Adeyemo, Modinat Wuraola Akinboade, Temitope Michael Akinleye, Kehinde Favour Siyanbola, Precious Ayomide Adeogun, Victor Michael Ogunfidodo, Christiana Adewumi Adekunle, Olubunmi Ayobami Elutade, Esther Eghogho Omoathebu, Blessing Oluwatunmise Taiwo, Elizabeth Olawumi Akindiya, Lucy Ochola, Helen Onyeaka   +13 more
doaj   +1 more source

Hedera helix subsp. helix

, 2020
Published as part of Buldrini, Fabrizio, Gentilini, Matteo, Bruni, Cinzia, Santini, Claudio, Alessandrini, Alessandro & Bosi, Giovanna, 2020, Flora vascolare spontanea della città di Modena: analisi del centro storico, pp. 3-56 in Natural History Sciences 7 (1) on page 49, DOI: 10.4081/nhs.2020.443, http://zenodo.org/record ...
Buldrini, Fabrizio, Gentilini, Matteo, Bruni, Cinzia, Santini, Claudio, Alessandrini, Alessandro, Bosi, Giovanna   +5 more
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Theorizing the Triple Helix model: Past, present, and future

, 2020
The Triple Helix of university-industry-government interactions, highlighting the enhanced role of the university in the transition from industrial to knowledge-based society, has become widespread in innovation and entrepreneurship studies.
Etzkowitz, Henry, Cai, Yuzhuo
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Novel Method for Predicting Lp(a) From Genomic Testing Identifies ASCVD Risk Across a Diverse Cohort

JACC: Basic to Translational Science
Summary: Lipoprotein(a) (Lp[a]) is a genetic and often unmeasured contributor to atherosclerotic cardiovascular disease (ASCVD) risk. In this study, Lp(a) was estimated from exome data by quantifying Kringle IV subtype 2 repeats alongside a single ...
Natalie Telis, PhD, Hang Dai, PhD, Ashley Waring, MD, David Kann, MD, Dana Wyman, PhD, Simon White, MSc, Basil Khuder, MS, Francisco Tanudjaja, BS, Alexandre Bolze, PhD, Matthew E. Levy, PhD, Cassie Hajek, MD, Lisa M. McEwen, PhD, Douglas Stoller, MD, Christopher N. Chapman, MD, C. Anwar A. Chahal, MD, PhD, Daniel P. Judge, MD, Douglas A. Olson, MD, Joseph J. Grzymski, PhD, Nicole L. Washington, PhD, William Lee, PhD, Elizabeth T. Cirulli, PhD, Shishi Luo, PhD, Kelly Schiabor Barrett, PhD   +22 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Bioinformatics designing of an mRNA vaccine for Mokola virus (MOKV) using immunoinformatics as a secure strategy for successful vaccine development

BMC Immunology
The Mokola Virus belongs to the family Rhabdoviridae and is genotype 3 of the Lyssavirus genera. A small number of cases of animal and human encephalomyelitis, mainly scattered over sub-Saharan Africa, have been linked to the Mokola Virus (MOKV ...
Elijah Kolawole Oladipo, James Akinwumi Ogunniran, Oluwaseyi Samuel Akinpelu, Tosin Omoboyede Omole, Stephen Feranmi Adeyemo, Boluwatife Ayobami Irewolede, Bamidele Abiodun Iwalokun, Olumide Faith Ajani, Helen Onyeaka   +8 more
doaj   +1 more source