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Effect of Seasonal Influenza Vaccines on Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Ferrets. [PDF]

Emerg Infect Dis
Sun X, Subbiah J, Belser JA, Brock N, Gansebom S, Li ZN, Jung YJ, Liu F, Tumpey TM, Maines TR, Levine MZ, York IA.   +11 more
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Structural and functional analysis of human parainfluenza virus type-1 hemagglutinin-neuraminidase protein

, 1994
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Nucleotide sequence of the gene encoding the Newcastle disease virus hemagglutinin-neuraminidase protein and comparisons of paramyxovirus hemagglutinin-neuraminidase protein sequences

Virus Research, 1987
The nucleotide sequence of cloned cDNA copies of the mRNA encoding the Newcastle disease virus (NDV), strain A-V, hemagglutinin-neuraminidase (HN) protein was determined. A single open reading frame in the sequence encodes a protein of 570 amino acids with a calculated molecular weight of 62,280. The predicted protein sequence contains only one obvious
Andrew Wilde, T G Morrison
exaly   +3 more sources

Modeling the paramyxovirus hemagglutinin-neuraminidase protein

Proteins: Structure, Function, and Genetics, 1997
The paramyxovirus hemagglutinin-neuraminidase (HN) protein exhibits neuraminidase activity and has an active site functionally similar to that in influenza neuraminidases. Earlier work identified conserved amino acids among HN sequences and proposed similarity between HN and influenza neuraminidase sequences.
V Chandana Epa
exaly   +3 more sources

Domain architecture and oligomerization properties of the paramyxovirus PIV 5 hemagglutinin-neuraminidase (HN) protein

Virology, 2008
The mechanism by which the paramyxovirus hemagglutinin-neuraminidase (HN) protein couples receptor binding to activation of virus entry remains to be fully understood, but the HN stalk is thought to play an important role in the process. We have characterized ectodomain constructs of the parainfluenza virus 5 HN to understand better the underlying ...
George P Leser, Börries Demeler, Robert A Lamb   +2 more
exaly   +3 more sources

Analysis of parainfluenza virus-5 hemagglutinin-neuraminidase protein mutants that are blocked in internalization and degradation

Virology, 2010
The PIV-5 hemagglutinin-neuraminidase (HN) protein is a multifunctional protein with sialic acid binding, neuraminidase and fusion promotion activity. HN is internalized by clathrin-mediated endocytosis and degraded. HN lacks internalization signals in its cytoplasmic tail but a single glutamic acid present at residue 37 at the putative transmembrane ...
Robert A Lamb
exaly   +3 more sources

Inhibition of Sendai Virus Hemagglutinin Neuraminidase by the Fusion Protein

Biochemical and Biophysical Research Communications, 1994
The Sendai virus envelope contains two glycoproteins: the fusion (F) protein and the hemagglutinin-neuraminidase (HN). Inactivation of F causes the loss of fusogenic activity and an increase of the neuraminidase activity of HN. After inactivation of F, HN can be inhibited by fetuin or asialofetuin, as already observed on the water-soluble, C-terminal ...
DALLOCCHIO, Franco Pasquale Filippo, Tomasi M., BELLINI, Tiziana   +2 more
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Variability of hemagglutinin-neuraminidase and nucleocapsid protein of vaccine and wild-type mumps virus strains

Infection, Genetics and Evolution, 2008
The mumps virus (MuV) molecular evolution is characterized by the co-circulation of numerous distinct strains. Standardized phylogenetic analyses based on the nucleotide sequences of the SH gene are important for mumps surveillance, but lack the information regarding antigenic properties.
Jelena Ivancic-Jelecki, Maja Santak, Dubravko Forcic   +2 more
exaly   +3 more sources

Role of N-linked glycosylation of the human parainfluenza virus type 3 hemagglutinin-neuraminidase protein

Virus Research, 2013
Human parainfluenza virus type 3 (hPIV-3) is a major respiratory tract pathogen that affects infants and young children. The hPIV-3 hemagglutinin-neuraminidase (HN) protein is a multifunctional protein mediating hemadsorption (HAD), neuraminidase (NA), and fusion promotion activities, each of which affects the ability of HN to promote viral fusion and ...
Fu-Lu Chu, Hongling Wen, Zhiyu Wang
exaly   +3 more sources

Identification of a variable epitope on the Newcastle disease virus hemagglutinin–neuraminidase protein

Veterinary Microbiology, 2010
Fifteen virulent Newcastle disease viruses (NDVs) were isolated from diseased birds in Eastern China in 2005. To investigate the antigenic variation in the epitopes on NDV hemagglutinin-neuraminidase (HN) protein, these isolates, together with six reference strains, were subjected to the hemagglutination inhibition (HI) tests using five HI-positive ...
Shunlin, Hu, Tongyan, Wang, Yuliang, Liu, Chun, Meng, Xiaoquan, Wang, Yantao, Wu, Xiufan, Liu   +6 more
openaire   +2 more sources