Results 141 to 150 of about 16,332 (165)

Antigenic variation in the hemagglutinin-neuraminidase protein of human parainfluenza type 3 virus

Virology, 1985
Sixteen monoclonal antibodies directed to the hemagglutinin-neuraminidase (HN) protein of a 1957 isolate of parainfluenza type 3 virus (PIV3) were produced and used to examine antigenic variation in clinical strains. Analysis of hemagglutination-inhibition reactivity patterns of antigenic variants selected in vitro in the presence of monoclonal ...
K L, van Wyke Coelingh, C, Winter, B R, Murphy   +2 more
openaire   +2 more sources

Cloning, expression and characterization of potential immunogenic recombinant hemagglutinin-neuraminidase protein of Porcine rubulavirus

Protein Expression and Purification, 2016
Blue eye disease caused by Porcine rubulavirus (PorPV) is an endemic viral infection of swine causing neurological and respiratory disease in piglets, and reproductive failure in sows and boars. The hemagglutinin-neuraminidase (HN) glycoprotein of PorPV is the most abundant component in the viral envelope and the main target of the immune response in ...
JOSÉ FRANCISCO Rivera-Benitez, Pablo Hernández-Jáuregui, Anne-Lie Blomstrom   +2 more
exaly   +3 more sources

The construction of recombinant Lactobacillus casei expressing hemagglutinin-neuraminidase protein and its immune response in chickens

Microbial Pathogenesis, 2021
Newcastle disease virus (NDV) is one of the most important diseases in poultry. The present study generated recombinant surface-displayed Lactobacillus casei (L. casei) expressing the hemagglutinin-neuraminidase (HN) of NDV (Lc-pPG-HN) and a live pPG vector (Lc-pPG) and evaluated their immunogenicity.
Anqi, Ju, Aoyi, Duan, Yingnan, Zhang, Yanjun, Qin, Ligang, Xue, Xin, Ma, Weimin, Luan, Shubao, Yang   +7 more
openaire   +2 more sources

Expression of hemagglutinin-neuraminidase protein of Newcastle disease virus in transgenic tobacco

Plant Biotechnology Reports, 2007
Newcastle disease is one of the most important pathogens of domestic poultry including chickens. The hemagglutinin-neuraminidase (HN) of Newcastle disease virus is the principal target of neutralizing and protective antibodies against Newcastle disease.
Bum-Soo Hahn, Ik-Soo Jeon, Young-Jae Jung, Jong-Bum Kim, Jong-Suk Park, Sun-Hwa Ha, Kyung-Hwan Kim, Hyeong-Mi Kim, Joo-Sung Yang, Yong-Hwan Kim   +9 more
openaire   +1 more source

Importance of serine 200 for functional activities of the hemagglutinin-neuraminidase protein of Newcastle Disease Virus

International Journal of Oncology, 2004
Newcastle disease virus (NDV) is an avian paramyxovirus with replication competence in human tumor cells and interesting anti-neoplastic and immune stimulatory properties. In order to increase tumor selectivity of replication, we prepared mutants from the avirulent strain Ulster with monocyclic replication cycle and adapted them for multicyclic ...
Philippe, Fournier, Jinyang, Zeng, Claus-W, Von Der Lieth, Birgit, Washburn, Thorsten, Ahlert, Volker, Schirrmacher   +5 more
openaire   +2 more sources

Computational Studies of Influenza A Virus at Three Important Targets: Hemagglutinin, Neuraminidase and M2 Protein

Current Pharmaceutical Design, 2011
While the seasonal influenza viruses spreading around the world cause the annual epidemics, the recent outbreaks of influenza A virus subtype H5N1 and pandemic H1N1 have raised a global human health concerns. In this review, the applicability of computational techniques focused on three important targets in the viral life cycle: hemagglutinin ...
Thanyada, Rungrotmongkol, Pathumwadee, Yotmanee, Nadtanet, Nunthaboot, Supot, Hannongbua   +3 more
openaire   +2 more sources

Anomeric Specificity and Protein–Substrate Interactions Support the 3D Model for the Hemagglutinin–Neuraminidase from Sendai Virus

Biochemical and Biophysical Research Communications, 1999
The 3D structure of paramyxovirus hemagglutinin-neuraminidase has not yet been resolved; however, a theoretical model has been built by using influenza virus and bacterial neuraminidases as template [V. C. Epa (1997) Proteins Struct. Funct. Gen. 29, 264-281]. Two common features of the catalytic mechanism of the neuraminidases of known 3D structure are
BELLINI, Tiziana, PASTI C., MANFRINATO, Maria Cristina, TOMASI M, DALLOCCHIO, Franco Pasquale Filippo   +4 more
openaire   +3 more sources

Retroviral expressed hemagglutinin-neuraminidase protein protects chickens from Newcastle disease virus induced disease

Microbial Pathogenesis, 1990
The hemagglutinin-neuraminidase (HN) gene and the phosphoprotein (P) gene of Newcastle disease virus (NDV) were inserted into a replication competent avian leukosis virus vector. The expression of the HN gene from this vector in chick embryo cells has been previously reported. The P gene is also expressed from this vector in chick embryo cells.
T, Morrison, V S, Hinshaw, M, Sheerar, A J, Cooley, D, Brown, C, McQuain, L, McGinnes   +6 more
openaire   +2 more sources

Structural features unique to each of the three antigenic sites on the hemagglutinin-neuraminidase protein of newcastle disease virus

Virology, 1988
Antigenic variants of D26 strain of Newcastle disease virus (NDV) were selected with monoclonal antibodies directed to the three nonoverlapping antigenic sites on the hemagglutinin-neuraminidase (HN) protein, and their HN genes were sequenced to identify the amino acids important for the integrity of each site.
B, Gotoh, T, Sakaguchi, K, Nishikawa, N M, Inocencio, M, Hamaguchi, T, Toyoda, Y, Nagai   +6 more
openaire   +2 more sources

Hemagglutinin-neuraminidase enhances F protein-mediated membrane fusion of reconstituted Sendai virus envelopes with cells

Journal of Virology, 1993
Reconstituted Sendai virus envelopes containing both the fusion (F) protein and the hemagglutinin-neuraminidase (HN) (F,HN-virosomes) or only the F protein (F-virosomes) were prepared by solubilization of the intact virus with Triton X-100 followed by its removal by using SM2 Bio-Beads.
S, Bagai, A, Puri, R, Blumenthal, D P, Sarkar   +3 more
openaire   +2 more sources