Results 121 to 130 of about 108,411 (200)

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, Volume 46, Issue 6, Page 1574-1602, November 2026.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

A replicating recombinant vesicular stomatitis virus model for dairy cattle H5N1 influenza virus glycoprotein evolution

Journal of Virology
A panzootic of highly pathogenic avian influenza (HPAI) H5N1 viruses from clade 2.3.4.4b has triggered a multistate outbreak in US dairy cattle and an unknown number of human infections.
Lindsey R. Robinson-McCarthy, Kylie E. Zirckel, Holly C. Simmons, Valerie Le Sage, Kevin R. McCarthy   +4 more
doaj   +1 more source

Rational Design of Glycolipid‐Based Coacervates for Sequestration of Macromolecules and Enveloped Viruses

Small Science, Volume 6, Issue 11, November 2026.
The rational design of novel glycolipid‐based self‐coacervates by tuning attractive (pi–pi and H‐bonding) and repulsive (electrostatic) interactions is reported. The low‐molecular‐weight glycolipid‐based MWGSD‐A4 coacervates can encapsulate dyes, drugs, proteins, and pathogenic viruses.
Nikesh Dewangan, Sandeep Yadav, Sarani Biswas, Indrani Das Jana, Ananya Ghosh, Priyaraj Pal, Arindam Mondal, Amirul Islam Mallick, Pradip Kumar Tarafdar   +8 more
wiley   +1 more source

Ciliated cells promote high infectious potential of influenza A virus through the efficient intracellular activation of hemagglutinin

Journal of Virology
Influenza viruses utilize host proteases to activate the viral fusion protein, hemagglutinin (HA), into its fusion-competent form. Although proteolytic activation of HA is essential for virus replication, the cell-type dependence of HA activation within ...
Zijian Guo, Victoria S. Banas, Yuanyuan He, Elizabeth Weiland, Jian Xu, Yangjie Tan, Zhaoxi Xiao, Steven L. Brody, Adrianus C. M. Boon, James W. Janetka, Michael D. Vahey   +10 more
doaj   +1 more source

Probiotics as a Strategy for Mitigating Viral Infections in Poultry: Immunomodulatory Mechanisms and Therapeutic Potential

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
Probiotics—particularly Lactobacillus acidophilus, L. casei and L. plantarum—may mitigate NDV, AIV and IBV infections by modulating immunity, supporting gut microbiome and barrier function, and enhancing vaccine responses, although stronger strain‐specific, safety, mechanistic and field‐based evidence is needed. ABSTRACT Poultry viral infections remain
Elmer Nayra Ametefe, Daniel Saka, Juliet Nuerkie Anang, Lourraine Sena Doh, Leonard Kofi Adjorlolo   +4 more
wiley   +1 more source

Virosomes: Beyond Vaccines

Life
Background: One of the primary strategies for preventing and reducing infectious diseases is vaccination. There are numerous licensed vaccinations of various kinds that can prevent viral infection by triggering the immune system’s reaction to specific ...
Hadeel K. Salameh, Mohammed M. Safi, Rafik Karaman   +2 more
doaj   +1 more source

Mechanisms of XCR1 Membrane Trafficking and Constitutive Endocytosis

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 5, November 2026.
ABSTRACT Chemokines orchestrate immune cell trafficking through receptor‐mediated signalling and are implicated in inflammatory, autoimmune and neuropathic disorders. The XCL1–XCR1 axis is of particular interest because XCR1 is selectively expressed on mature conventional type 1 dendritic cells (cDC1s), where it supports communication with activated ...
Qiao Li, Fabian Pfersdorf, Fernando Salgado‐Polo, Martin Gustavsson   +3 more
wiley   +1 more source

Genetic and Serological Analysis of H7N3 Avian Influenza Viruses in Mexico for Pandemic Risk Assessment

Viruses
Avian influenza A viruses pose ongoing threats to human and animal health, with H7 subtypes causing outbreaks globally. In Mexico, highly pathogenic H7N3 viruses have circulated in poultry since 2012, causing sporadic human infections.
Guadalupe Ayora-Talavera, Irma López-Martínez, Gisela Barrera-Badillo, Rodrigo Aparicio-Antonio, Nidia Aréchiga-Ceballos, Anita Aguirre-Barbosa, Rosa Maria Wong-Chew, Daniel Canul-Canul, Mario Solís-Hernández   +8 more
doaj   +1 more source

Genomic and Clinical Analysis of Influenza A in Hospitalized Adults, 2019–2024: Exploratory Evidence on Neuraminidase and Polymerase Acidic Protein Mutation‐Outcome Associations From a Single Center

Influenza and Other Respiratory Viruses, Volume 20, Issue 11, November 2026.
ABSTRACT Background Antivirals are widely used to treat influenza, but potential resistance mutations remain a major challenge, and clinical data on key resistance mutations are limited. Methods We conducted a retrospective cohort study of 765 adults with RT‐PCR‐confirmed influenza A admitted to Ruijin Hospital, Shanghai, between 2019 and 2024 to ...
Anqi Feng, Wei Tan, Wenxin Xu, Xinxin Zhang, Dong Wei, Zhitao Yang   +5 more
wiley   +1 more source

Botulinum Toxin Complex Serotype B-Okra Exerts Systemic Toxicity via the Oral Route by Disrupting the Intestinal Epithelial Barrier

Toxins
Botulinum toxin (BoNT) causes flaccid paralysis by blocking the release of neurotransmitters. BoNTs associate with neurotoxin-associated proteins to form medium and large progenitor toxin complexes.
Chiyono Morimoto, Sho Amatsu, Takuhiro Matsumura, Masahiko Zuka, Yukako Fujinaga   +4 more
doaj   +1 more source