Results 131 to 140 of about 108,411 (200)

Elucidating the Molecular Impact of DA29‐Induced ClpP Chemoactivation on Mitochondrial Function

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
A promising approach to tackling DIPG, a lethal pediatric brain tumor, relies on small molecules capable of activating the human mitochondrial protease hClpP. The novel piperazine‐based compound DA29 specifically activates endogenous hClpP, thereby compromising mtDNA levels, mitoribosomes, and OXPHOS complex subunits.
Francesca Rizzo, Morena Miciaccia, Maria Grazia Perrone, Antonio Scilimati, Paola Loguercio Polosa, Francesco Bruni   +5 more
wiley   +1 more source

Bioorthogonal Chemistry in Neurobiology: From Imaging to Proteomics

ChemBioChem, Volume 27, Issue 20, 28 October 2026.
This review highlights emerging strategies for labeling neuronal proteins, enabling visualization and quantitative analysis of their expression, localization, and dynamics. By combining genetic code expansion (GCE), metabolic labeling, and click chemistry‐based labeling, these approaches provide powerful routes to study proteins in specific cells and ...
Neil Taylor, João de Sousa‐Lourenço, Ivana Nikić‐Spiegel   +2 more
wiley   +1 more source

Differentiating Avian and Seasonal Influenza Viruses in Wastewater by Digital PCR. [PDF]

Emerg Infect Dis
Paracchini V, Petrillo M, Leon FM, Buttinger G, Marciano S, Crimaudo M, Terregino C, Veneri C, La Rosa G, Suffredini E, Cocuzza C, Gawlik BM, Wiesenthal T, Vincent U, Panzarin V, Marchini A.   +15 more
europepmc   +1 more source

Residues Ser83, Arg85, Tyr88, Asn124, and Lys192 of C-Terminal Lipid-Associated Membrane Hemagglutinin Affect <i>Mycoplasma synoviae</i> Agglutination of Erythrocytes. [PDF]

Microorganisms
Si D, Bao S, Guo L, Chen X, Wen F, He X, Wang Q, Shi Y, He S, Li J.   +9 more
europepmc   +1 more source

N-linked glycosylation sites with low occupancy support sustained circulation of the A(H3N2) influenza A virus in the human population. [PDF]

J Virol
Alymova IV, Mekonnen B, Wang D, Kamal RP, Tzeng W-P, Jureka AS, Barr JR, Gansebom S, York IA.   +8 more
europepmc   +1 more source

Evaluation of the Therapeutic Potential of Natural Peptides Against Hemagglutinin-Esterase of Bovine Coronavirus Based on Molecular Dynamics Simulation Studies. [PDF]

Vet Med Int
Al-Battat MAH, Gharouni M, Nassiri M, Javadmanesh A, Asoodeh A, Tohidi R.   +5 more
europepmc   +1 more source

Rapid Identification of H3N2 Influenza A Virus HA-Targeting Antibody Epitopes Driven by Computational Antibody Similarity Measures. [PDF]

ACS Omega
Zhu Z, Chen Z, Wu J, Han J, Li L, Qian K, Cui Y, Li Z, Ding R, Pang S, Zhang G, Yu C, Chi X.   +12 more
europepmc   +1 more source

Analysis of HA5 Hemagglutinins from Influenza A Viruses for Mass-Charge Patterns to Understand Antigenic Drift Related to Immune Escape. [PDF]

Viruses
Zhang W, Wu X, Zhu R, Pan X, Yu S, Wang J, Huang JS, Zhang W.   +7 more
europepmc   +1 more source

Antiviral Activity of the Polyene Macrolide Roseofungin Against Influenza a Virus: In Vitro, In Ovo, and Preliminary In Vivo Evaluation. [PDF]

Viruses
Bogoyavlenskiy A, Berezin V, Alexyuk P, Alexyuk M, Zaitseva I, Mukhametkaliyev A, Moldakhanov Y, Anarkulova E, Kerimov T, Dushenkov V.   +9 more
europepmc   +1 more source

Discovery and Structure-Activity Relationship Studies of Thienopyrroles as Group 2 Influenza A Entry Inhibitors. [PDF]

ACS Med Chem Lett
Sloan JP, Bott R, Sacramento CQ, Zielinski C, Durante DI, Peet NP, Gaisina IN, Rong L, Moore TW.   +8 more
europepmc   +1 more source