Results 51 to 60 of about 136,346 (223)

Genetic characteristics analysis of the hemagglutinin gene of measles virus in Shanghai， 2001‒2018

Shanghai yufang yixue, 2022
ObjectiveTo analyze the genetic characteristics of the hemagglutinin （H） gene of measles virus （MeV） in Shanghai， 2001‒2018.MethodsNasopharyngeal swab specimens were collected from suspected measles cases reported in Shanghai from 2001 to 2018， and the ...
YANG Yuying, CHEN Dayu, TANG Wei, LI Yunyi, WANG Jiayu, LI Shupei, LI Chongshan   +6 more
doaj   +1 more source

A Real‐Time Antifouling Multivalent Aptamer Platform for Wash‐Free Electrochemical Detection of Low‐Abundance Biomarkers in Human Plasma

Angewandte Chemie, EarlyView.
Detection of low‐abundance proteins at the point‐of‐care is key for early detection and real‐time monitoring. The clinical translation of such assays is hindered by biofouling, matrix variability, and signal instability. RT‐MagMAp assay overcomes these challenges and enables precise protein quantification in human plasma using a hierarchical assembly ...
Payel Sen, Survanshu Saxena, Zijie Zhang, Navreen Sandhu, Pranati Das, Jimmy Gu, Todd Hoare, Yingfu Li, Leyla Soleymani   +8 more
wiley   +2 more sources

Imprinted Anti-Hemagglutinin and Anti-Neuraminidase Antibody Responses after Childhood Infections of A(H1N1) and A(H1N1)pdm09 Influenza Viruses

mBio, 2023
Immune imprinting is a driver known to shape the anti-hemagglutinin (HA) antibody landscape of individuals born within the same birth cohort. With the HA and neuraminidase (NA) proteins evolving at different rates under immune selection pressures, anti ...
Pavithra Daulagala, Brian R. Mann, Kathy Leung, Eric H. Y. Lau, Louise Yung, Ruipeng Lei, Sarea I. N. Nizami, Joseph T. Wu, Susan S. Chiu, Rodney S. Daniels, Nicholas C. Wu, David Wentworth, Malik Peiris, Hui-Ling Yen   +13 more
doaj   +1 more source

Influenza research database: an integrated bioinformatics resource for influenza research and surveillance. [PDF]

, 2012
BackgroundThe recent emergence of the 2009 pandemic influenza A/H1N1 virus has highlighted the value of free and open access to influenza virus genome sequence data integrated with information about other important virus characteristics.DesignThe ...
Baumgarth, Nicole, Deitrich, Jon, García-Sastre, Adolfo, Hunt, Victoria, Klem, Edward, Kumar, Sanjeev, Larsen, Christopher N, Macken, Catherine, Noronha, Jyothi, Pickett, Brett E, Ramsey, Alvin, Scheuermann, Richard H, Squires, R Burke, Suarez, David, Zaremba, Sam, Zhang, Yun, Zhou, Liwei   +16 more
core   +1 more source

Chlamydial hemagglutinin identified as lipopolysaccharide [PDF]

Journal of Bacteriology, 1987
Chlamydial lipopolysaccharide (LPS) agglutinated mouse and rabbit erythrocytes but not human, guinea pig, or pronghorn antelope erythrocytes. Hemagglutination was not specific for Chlamydia spp., as rough LPSs from Coxiella burnetii and Escherichia coli also agglutinated erythrocytes from the same animal species.
N G, Watkins, H D, Caldwell, T, Hackstadt   +2 more
openaire   +2 more sources

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Calcium Shock Enables Efficient and Programmable Particle Delivery for Genome Editing Applications

Advanced Science, EarlyView.
Classical transfection and transduction are inefficient, particularly with confluent cells and organoids, and lack cell type‐specific programmability. This study presents calcium shock (CaSh), a method that dramatically improves particle delivery into single cells, colonies, and organoids.
Nicole Vo, Lorena de Oñate, Maximillian Frank, Xian Hu, Sophie M. Blackburn, Dana V. Foss, Jasmine Villegas, Kunica Asija, Dirk Hockemeyer, Hongxia Fu, Raymond J. Monnat, Ross C. Wilson, Benjamin S. Freedman   +12 more
wiley   +1 more source

Sequence variation in the haemagglutinin-neuraminidase gene of human parainfluenza virus type 3 isolates in the UK [PDF]

, 1995
The sequence variation in a 934 base-pair region of the gene encoding the haemagglutinin-neuraminidase of five human parainfluenza virus type 3 (HPIV3) isolates was determined together with that of a prototype UK strain. All of the clinical isolates were
K. R. Collins, A. J. Easton, Cane, Colman, Elango, Sambrook, van Wyke Coelingh   +6 more
core   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

Altering the Immunogenicity of Hemagglutinin Immunogens by Hyperglycosylation and Disulfide Stabilization

Frontiers in Immunology, 2021
Influenza virus alters glycosylation patterns on its surface exposed glycoproteins to evade host adaptive immune responses. The viral hemagglutinin (HA), in particular the H3 subtype, has increased its overall surface glycosylation since its introduction
Dana N. Thornlow, Dana N. Thornlow, Andrew N. Macintyre, Thomas H. Oguin, Amelia B. Karlsson, Erica L. Stover, Heather E. Lynch, Gregory D. Sempowski, Gregory D. Sempowski, Aaron G. Schmidt, Aaron G. Schmidt   +10 more
doaj   +1 more source