Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly. [PDF]
PLOS Pathogens, 2015 Nipah virus (NiV) is a paramyxovirus that infects host cells through the coordinated efforts of two envelope glycoproteins. The G glycoprotein attaches to cell receptors, triggering the fusion (F) glycoprotein to execute membrane fusion.
Aguilar, Hector C +14 more
core +11 more sources
Dual Mutation Events in the Haemagglutinin-Esterase and Fusion Protein from an Infectious Salmon Anaemia Virus HPR0 Genotype Promote Viral Fusion and Activation by an Ubiquitous Host Protease [PDF]
, 2015 Funding: The Scottish Government funded this work, as part of their global budget on aquaculture research. The funder had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer ...
Collet, Bertrand +6 more
core +14 more sources
Independent and disparate evolution in nature of influenza A virus hemagglutinin and neuraminidase glycoproteins. [PDF]
Proceedings of the National Academy of Sciences, 1990 The hemagglutinin (HA) and neuraminidase (NA) external glycoprotein antigens of H1N1 and H3N2 subtypes of epidemiologically important influenza A viruses prevalent during recent decades were subjected to intensive antigenic analysis by four different methods.
Edwin D. Kilbourne +2 more
openaire +3 more sources
Fusion Activity of Transmembrane and Cytoplasmic Domain Chimeras of the Influenza Virus Glycoprotein Hemagglutinin [PDF]
Journal of Virology, 1998 ABSTRACTThe role of the sequence of transmembrane and cytoplasmic/intraviral domains of influenza virus hemagglutinin (HA, subtype H7) for HA-mediated membrane fusion was explored. To analyze the influence of the two domains on the fusogenic properties of HA, we designed HA-chimeras in which the cytoplasmic tail and/or transmembrane domain of HA was ...
Britta Schroth-Diez +4 more
openaire +2 more sources
Influenza A Virus Hemagglutinin and Other Pathogen Glycoprotein Interactions with NK Cell Natural Cytotoxicity Receptors NKp46, NKp44, and NKp30 [PDF]
Viruses, 2021 Natural killer (NK) cells are part of the innate immunity repertoire, and function in the recognition and destruction of tumorigenic and pathogen-infected cells. Engagement of NK cell activating receptors can lead to functional activation of NK cells, resulting in lysis of target cells.
Sydney L. Ronzulli +3 more
openaire +3 more sources
Hemolytic activity of influenza virus hemagglutinin glycoproteins activated in mildly acidic environments. [PDF]
Proceedings of the National Academy of Sciences, 1983 Hemagglutinin (HA) glycoproteins isolated from influenza virus caused hemolysis and liposome lysis at pH less than 6.0. The pH dependence was similar to that of the parent virus. Hemagglutination and hemolysis titers of HA were comparable with those of virus. The time course of hemolysis by HA was somewhat different from that by virus. HA did not cause
Kazunori Kawasaki +2 more
openaire +3 more sources
The role of stearate attachment to the hemagglutinin-esterase-fusion glycoprotein HEF of influenza C virus [PDF]
Cellular Microbiology, 2015 The only spike of influenza C virus, the hemagglutinin-esterase-fusion glycoprotein (HEF) combines receptor binding, receptor hydrolysis and membrane fusion activities. Like other hemagglutinating glycoproteins of influenza viruses HEF is S-acylated, but only with stearic acid at a single cysteine located at the cytosol-facing end of the transmembrane ...
Michael Veit +3 more
openaire +3 more sources
A Viable Recombinant Rhabdovirus Lacking Its Glycoprotein Gene and Expressing Influenza Virus Hemagglutinin and Neuraminidase Is a Potent Influenza Vaccine [PDF]
Journal of Virology, 2015 ABSTRACT The emergence of novel influenza viruses that cause devastating human disease is an ongoing threat and serves as an impetus for the continued development of novel approaches to influenza vaccines. Influenza vaccine development has traditionally focused on producing humoral and/or cell-mediated immunity, often against the
Leatrice Vogel +5 more
openaire +3 more sources
Functional expression in primate cells of cloned DNA coding for the hemagglutinin surface glycoprotein of influenza virus. [PDF]
Proceedings of the National Academy of Sciences, 1981 We have used simian virus 40 (SV40) DNA as a vector for expression of functional activity of a cloned influenza viral DNA segment in primate cells. Cloned full-length DNA sequences coding for the hemagglutinin of influenza A virus (Udorn/72/[H3N2]) were inserted into the late region of a viable deletion mutant of SV40, and the hybrid DNA was propagated
Michael M. Sveda, Ching-Juh Lai
openaire +3 more sources
Recognition of viral glycoproteins by influenza A-specific cross- reactive cytolytic T lymphocytes [PDF]
, 1980 Two populations of cytolytic T lymphocytes (CTL) generated after influenza A virus infection can be distinguished into one with specificity for the sensitizing hemagglutinin type and a second with cross-reactivity for antigens induced by other type-A ...
Allen, H. +4 more
core +2 more sources