Results 1 to 10 of about 13,620 (172)

Sulfur-containing class of broad-spectrum antivirals improves influenza virus vaccine development [PDF]

Nature Communications
Enveloped viruses are significant zoonotic disease threats with the potential to cause global pandemics. We identified a class of small-molecule sulfur-containing antiviral compounds (XM series) that broadly inhibit enveloped viruses.
David W. Buchholz, Armando Pacheco, Sreetama Pal, I. Abrrey Monreal, Shi Xu, Brian Imbiakha, Julie Sahler, Mason Jager, Alex Liqi Lai, Erik M. Contreras, Shahrzad Ezzatpour, Brandan Cook, Elshan Ralalage, Qian Liu, Yao Yu Yeo, Andrew Ma, Haewon Byun, Obaed Shah, J. Lizbeth Reyes Zamora, Niraj K. Shil, Sara Jones-Burrage, Suzanne M. Pritchard, Chuntao Yang, Yu Zhao, Zeinab J. Mohamed, Cheyan Xu, Michael J. Jung, Gerlinde R. Van de Walle, Suchetana Mukhopadhyay, Masako Shimamura, Alan G. Goodman, Michele Hardy, Santanu Bose, Anthony V. Nicola, Jack H. Freed, Avery August, Susan Daniel, Petr Chlanda, Jace W. Jones, Ming Xian, Hector C. Aguilar   +40 more
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A replicating recombinant vesicular stomatitis virus model for dairy cattle H5N1 influenza virus glycoprotein evolution [PDF]

Journal of Virology
A panzootic of highly pathogenic avian influenza (HPAI) H5N1 viruses from clade 2.3.4.4b has triggered a multistate outbreak in US dairy cattle and an unknown number of human infections.
Lindsey R. Robinson-McCarthy, Kylie E. Zirckel, Holly C. Simmons, Valerie Le Sage, Kevin R. McCarthy   +4 more
doaj   +2 more sources

N-glycosylation at the receptor binding site drives differences in receptor binding specificity between influenza B virus lineages [PDF]

Journal of Virology
Receptor specificity plays a critical role in influenza virus host tropism and pathogenesis. Influenza A and influenza B viruses (FLUAVs and FLUBVs, respectively) utilize N-glycans with terminal sialic acids on glycoproteins decorating the surface of ...
Caroline K. Page, M. H. M. Mubassir, Pradeep Chopra, Lindsey Claire Gay, Ginger Geiger, Sean D. Ray, Justin D. Shepard, Rose J. Miller, Daniel Perez, Justin Bahl, Gerardus Josephus Boons, Stephen Mark Tompkins   +11 more
doaj   +2 more sources

Unsupervised classification of influenza virus surface spikes from cryo-EM reconstructions using head-to-stem width ratio [PDF]

Virology Journal
Accurate identification of influenza virus surface glycoproteins—hemagglutinin (HA) and neuraminidase (NA)—is critical for understanding viral morphology and supporting vaccine development.
Younes Benkarroum
doaj   +2 more sources

Analysis of the Evolution of Pandemic Influenza A(H1N1) Virus Neuraminidase Reveals Entanglement of Different Phenotypic Characteristics

mBio, 2021
Since its emergence in 2009, the pandemic H1N1 influenza A virus (IAV) has caused significant disease and mortality in humans. IAVs contain two envelope glycoproteins, the receptor-binding hemagglutinin (HA) and the receptor-destroying neuraminidase (NA).
Meiling Dai, Wenjuan Du, Carles Martínez-Romero, Tim Leenders, Tom Wennekes, Guus F. Rimmelzwaan, Frank J. M. van Kuppeveld, Ron A. M. Fouchier, Adolfo Garcia-Sastre, Erik de Vries, Cornelis A. M. de Haan   +10 more
doaj   +1 more source

B Cell Responses against Influenza Viruses: Short-Lived Humoral Immunity against a Life-Long Threat

Viruses, 2021
Antibodies are critical for providing protection against influenza virus infections. However, protective humoral immunity against influenza viruses is limited by the antigenic drift and shift of the major surface glycoproteins, hemagglutinin and ...
Jenna J. Guthmiller, Henry A. Utset, Patrick C. Wilson   +2 more
doaj   +1 more source

Chemoenzymatic site-specific labeling of influenza glycoproteins as a tool to observe virus budding in real time. [PDF]

PLoS Pathogens, 2012
The influenza virus uses the hemagglutinin (HA) and neuraminidase (NA) glycoproteins to interact with and infect host cells. While biochemical and microscopic methods allow examination of the early steps in flu infection, the genesis of progeny virions ...
Maximilian Wei-Lin Popp, Roos A Karssemeijer, Hidde L Ploegh   +2 more
doaj   +1 more source

Antiviral Activities of Ethyl Pheophorbides a and b Isolated from Aster pseudoglehnii against Influenza Viruses

Molecules, 2022
Screening of the antiviral and virucidal activities of ethanol extracts from plants endemic to the Republic of Korea revealed the inhibitory activity of a 70% ethanol extract of the whole plant of A. pseudoglehnii (APE) against influenza virus infection.
Subin Park, Ji-Young Kim, Hak Cheol Kwon, Dae Sik Jang, Yoon-Jae Song   +4 more
doaj   +1 more source

Adaptation of the H7N2 Feline Influenza Virus to Human Respiratory Cell Culture

Viruses, 2022
During 2016–2017, the H7N2 feline influenza virus infected more than 500 cats in animal shelters in New York, USA. A veterinarian who had treated the cats became infected with this feline virus and showed mild respiratory symptoms. This suggests that the
Wataru Sekine, Akiko Takenaka-Uema, Haruhiko Kamiki, Hiroho Ishida, Hiromichi Matsugo, Shin Murakami, Taisuke Horimoto   +6 more
doaj   +1 more source

Mucosal vaccination with recombinant adenovirus encoding nucleoprotein provides potent protection against influenza virus infection. [PDF]

PLoS ONE, 2013
Influenza vaccines that target the highly variable surface glycoproteins hemagglutinin and neuraminidase cause inconvenience of having vaccination every year.
So-Hee Kim, Joo Young Kim, Youngjoo Choi, Huan H Nguyen, Man Ki Song, Jun Chang   +5 more
doaj   +1 more source