Results 1 to 10 of about 21,210 (213)

TMEM259/MEMBRALIN is a non-canonical ER-phagy receptor that associates with MAN1B1 and VCP to eliminate viral glycoproteins [PDF]

Autophagy Reports
Selective autophagy of the endoplasmic reticulum (ER-phagy/reticulophagy) is essential for organelle homeostasis and host defense, yet how ER quality control (ERQC) pathways distinguish viral glycoproteins from misfolded host proteins remains poorly ...
Jim Maurice Camilleri, Jing Zhang, Tao Wang, Iqbal Ahmad, Sunan Li, Yong-Hui Zheng   +5 more
doaj   +2 more sources

An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism. [PDF]

PLOS Pathogens, 2016
Influenza viruses cause seasonal flu each year and pandemics or epidemic sporadically, posing a major threat to public health. Recently, a new influenza D virus (IDV) was isolated from pigs and cattle. Here, we reveal that the IDV utilizes 9-O-acetylated
Chen, Xi, Diaz, Sandra, Gao, George F, Khedri, Zahra, Qi, Jianxun, Shi, Yi, Song, Hao, Varki, Ajit, Yu, Hai   +8 more
core   +10 more sources

Potential recombinant vaccine against influenza A virus based on M2e displayed on nodaviral capsid nanoparticles [PDF]

International Journal of Nanomedicine, 2015
Chean Yeah Yong,1 Swee Keong Yeap,2 Kok Lian Ho,3 Abdul Rahman Omar,2,4 Wen Siang Tan1,2 1Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, 2Institute of Bioscience, 3Department of Pathology, Faculty of Medicine and Health ...
Yong CY, Yeap SK, Ho KL, Omar AR, Tan WS
doaj   +4 more sources

Sulfur-containing class of broad-spectrum antivirals improves influenza virus vaccine development [PDF]

Nature Communications
Enveloped viruses are significant zoonotic disease threats with the potential to cause global pandemics. We identified a class of small-molecule sulfur-containing antiviral compounds (XM series) that broadly inhibit enveloped viruses.
David W. Buchholz, Armando Pacheco, Sreetama Pal, I. Abrrey Monreal, Shi Xu, Brian Imbiakha, Julie Sahler, Mason Jager, Alex Liqi Lai, Erik M. Contreras, Shahrzad Ezzatpour, Brandan Cook, Elshan Ralalage, Qian Liu, Yao Yu Yeo, Andrew Ma, Haewon Byun, Obaed Shah, J. Lizbeth Reyes Zamora, Niraj K. Shil, Sara Jones-Burrage, Suzanne M. Pritchard, Chuntao Yang, Yu Zhao, Zeinab J. Mohamed, Cheyan Xu, Michael J. Jung, Gerlinde R. Van de Walle, Suchetana Mukhopadhyay, Masako Shimamura, Alan G. Goodman, Michele Hardy, Santanu Bose, Anthony V. Nicola, Jack H. Freed, Avery August, Susan Daniel, Petr Chlanda, Jace W. Jones, Ming Xian, Hector C. Aguilar   +40 more
doaj   +2 more sources

N-glycosylation at the receptor binding site drives differences in receptor binding specificity between influenza B virus lineages [PDF]

Journal of Virology
Receptor specificity plays a critical role in influenza virus host tropism and pathogenesis. Influenza A and influenza B viruses (FLUAVs and FLUBVs, respectively) utilize N-glycans with terminal sialic acids on glycoproteins decorating the surface of ...
Caroline K. Page, M. H. M. Mubassir, Pradeep Chopra, Lindsey Claire Gay, Ginger Geiger, Sean D. Ray, Justin D. Shepard, Rose J. Miller, Daniel Perez, Justin Bahl, Gerardus Josephus Boons, Stephen Mark Tompkins   +11 more
doaj   +2 more sources

Unsupervised classification of influenza virus surface spikes from cryo-EM reconstructions using head-to-stem width ratio [PDF]

Virology Journal
Accurate identification of influenza virus surface glycoproteins—hemagglutinin (HA) and neuraminidase (NA)—is critical for understanding viral morphology and supporting vaccine development.
Younes Benkarroum
doaj   +2 more sources

Analysis of the Evolution of Pandemic Influenza A(H1N1) Virus Neuraminidase Reveals Entanglement of Different Phenotypic Characteristics

mBio, 2021
Since its emergence in 2009, the pandemic H1N1 influenza A virus (IAV) has caused significant disease and mortality in humans. IAVs contain two envelope glycoproteins, the receptor-binding hemagglutinin (HA) and the receptor-destroying neuraminidase (NA).
Meiling Dai, Wenjuan Du, Carles Martínez-Romero, Tim Leenders, Tom Wennekes, Guus F. Rimmelzwaan, Frank J. M. van Kuppeveld, Ron A. M. Fouchier, Adolfo Garcia-Sastre, Erik de Vries, Cornelis A. M. de Haan   +10 more
doaj   +1 more source

Dual Mutation Events in the Haemagglutinin-Esterase and Fusion Protein from an Infectious Salmon Anaemia Virus HPR0 Genotype Promote Viral Fusion and Activation by an Ubiquitous Host Protease [PDF]

, 2015
Funding: The Scottish Government funded this work, as part of their global budget on aquaculture research. The funder had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer ...
Collet, Bertrand, Falk, Knut, Fourrier, Mickael, Lester, Katherine, Markussen, Turhan, McBeath, Alastair, Secombes, Christopher J   +6 more
core   +15 more sources

B Cell Responses against Influenza Viruses: Short-Lived Humoral Immunity against a Life-Long Threat

Viruses, 2021
Antibodies are critical for providing protection against influenza virus infections. However, protective humoral immunity against influenza viruses is limited by the antigenic drift and shift of the major surface glycoproteins, hemagglutinin and ...
Jenna J. Guthmiller, Henry A. Utset, Patrick C. Wilson   +2 more
doaj   +1 more source

Chemoenzymatic site-specific labeling of influenza glycoproteins as a tool to observe virus budding in real time. [PDF]

PLoS Pathogens, 2012
The influenza virus uses the hemagglutinin (HA) and neuraminidase (NA) glycoproteins to interact with and infect host cells. While biochemical and microscopic methods allow examination of the early steps in flu infection, the genesis of progeny virions ...
Maximilian Wei-Lin Popp, Roos A Karssemeijer, Hidde L Ploegh   +2 more
doaj   +1 more source