Hemolytic activity of influenza virus hemagglutinin glycoproteins activated in mildly acidic environments. [PDF]
Proceedings of the National Academy of Sciences, 1983 Hemagglutinin (HA) glycoproteins isolated from influenza virus caused hemolysis and liposome lysis at pH less than 6.0. The pH dependence was similar to that of the parent virus. Hemagglutination and hemolysis titers of HA were comparable with those of virus. The time course of hemolysis by HA was somewhat different from that by virus. HA did not cause
S B, Sato, K, Kawasaki, S, Ohnishi
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Influenza A Virus Hemagglutinin and Other Pathogen Glycoprotein Interactions with NK Cell Natural Cytotoxicity Receptors NKp46, NKp44, and NKp30 [PDF]
Viruses, 2021 Natural killer (NK) cells are part of the innate immunity repertoire, and function in the recognition and destruction of tumorigenic and pathogen-infected cells. Engagement of NK cell activating receptors can lead to functional activation of NK cells, resulting in lysis of target cells.
Jasmina M. Luczo +2 more
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mBio, 2020 Enveloped viruses express three classes of fusion proteins that are required for their entry into host cells via mediating virus and cell membrane fusion. Class I fusion proteins are produced from influenza viruses, retroviruses, Ebola viruses, and coronaviruses.
Changqing Yu +9 more
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Fusion Activity of Transmembrane and Cytoplasmic Domain Chimeras of the Influenza Virus Glycoprotein Hemagglutinin [PDF]
Journal of Virology, 1998 ABSTRACTThe role of the sequence of transmembrane and cytoplasmic/intraviral domains of influenza virus hemagglutinin (HA, subtype H7) for HA-mediated membrane fusion was explored. To analyze the influence of the two domains on the fusogenic properties of HA, we designed HA-chimeras in which the cytoplasmic tail and/or transmembrane domain of HA was ...
B, Schroth-Diez +4 more
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SERINC5 restricts influenza virus infectivity.
PLoS Pathogens, 2022 SERINC5 is a multi-span transmembrane protein that is incorporated into HIV-1 particles in producing cells and inhibits HIV-1 entry. Multiple retroviruses like HIV-1, equine infectious anemia virus and murine leukemia virus are subject to SERINC5 ...
Fei Zhao +14 more
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Influenza Virus Hemagglutinin Glycoproteins with Different N-Glycan Patterns Activate Dendritic Cells In Vitro [PDF]
Journal of Virology, 2016 ABSTRACT Influenza virus hemagglutinin (HA) N-glycans play important regulatory roles in the control of virus virulence, antigenicity, receptor-binding specificity, and viral escape from the immune response. Considered essential for controlling innate and adaptive immune responses against influenza virus infections, dendritic ...
Wen-Chun, Liu +5 more
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Characterization of potent fusion inhibitors of influenza virus. [PDF]
PLoS ONE, 2015 New inhibitors of influenza viruses are needed to combat the potential emergence of novel human influenza viruses. We have identified a class of small molecules that inhibit replication of influenza virus at picomolar concentrations in plaque reduction ...
Michael Rowse +8 more
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Phage-Mediated Presentation of a Conserved HA2 Epitope From Influenza A Virus Elicits Significant IgY Antibody Responses in Broiler Chickens. [PDF]
Vet Med SciThe conserved region of HA2 peptide of Influenza A virus was expressed on the surface of Protein VIII from M13 phage. Immunization of broiler chickens by this hybrid phage showed high levels of antibody responses, highlighting its potential as a promising tool for universal vaccine development against Influenza A virus.
Lotfi Z, Golchin M, Shamshirgaran MA.
europepmc +2 more sources
Independent and disparate evolution in nature of influenza A virus hemagglutinin and neuraminidase glycoproteins. [PDF]
Proceedings of the National Academy of Sciences, 1990 The hemagglutinin (HA) and neuraminidase (NA) external glycoprotein antigens of H1N1 and H3N2 subtypes of epidemiologically important influenza A viruses prevalent during recent decades were subjected to intensive antigenic analysis by four different methods.
E D, Kilbourne +2 more
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Cleavage of hemagglutinin-bearing lentiviral pseudotypes and their use in the study of influenza virus persistence. [PDF]
PLoS ONE, 2014 Influenza A viruses (IAVs) are a major cause of infectious respiratory human diseases and their transmission is dependent upon the environment. However, the role of environmental factors on IAV survival outside the host still raises many questions.
Olivier Sawoo +5 more
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