Association of influenza virus proteins with membrane rafts [PDF]
Advances in Virology, 2011 Assembly and budding of influenza virus proceeds in the viral budozone, a domain in the plasma membrane with characteristics of cholesterol /sphingolipid-rich membrane rafts. The viral transmembrane glycoproteins hemagglutinin (HA) and neuraminidase (NA)
Thaa, Bastian, Veit, Michael
core +6 more sources
Cross-neutralization of Influenza A by SARS-CoV-2 specific neutralizing antibodies and polyclonal plasma: Is pre-exposure to SARS-CoV-2 protective against Influenza A? [PDF]
HeliyonAccording to sparse information from various countries, the seasonal influenza virus circulation has drastically decreased during the COVID-19 pandemic. Here, we show the cross-reactivity of anti-SARS-CoV-2 antibodies against influenza viruses.
Mohammad Mamun Alam +8 more
doaj +2 more sources
Design, Synthesis and Anti‐Influenza Virus Activity of 4‐Tert‐Butyl‐N‐(3‐Oxo‐1‐Thia‐4‐Azaspiro[4.5]Dec‐4‐yl)Benzamide Derivatives That Target Hemagglutinin‐Mediated Fusion [PDF]
Drug Development Research, Volume 86, Issue 2, April 2025.ABSTRACT Hemagglutinin (HA) is a viral glycoprotein that mediates influenza virus entry into the host cell and is considered a relevant viral target. We here report the identification of a class of 4‐tert‐butylphenyl‐substituted spirothiazolidinones as HA‐mediated fusion inhibitors with specific activity against influenza A/H3N2 virus.
Gözde Çınar +4 more
wiley +2 more sources
Administration of antigenically distinct influenza viral particle combinations as an influenza vaccine strategy. [PDF]
PLoS PathogensOne approach for developing a more universal influenza vaccine is to elicit strong immune responses against canonically immunosubdominant epitopes in the surface exposed viral glycoproteins.
Xinyu Zhu +5 more
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Exploring TMPRSS2 Drug Target to Combat Influenza and Coronavirus Infection [PDF]
ScientificaRespiratory viral infections, including influenza and coronaviruses, present significant health risks worldwide. The recent COVID-19 pandemic highlights the urgent need for novel and effective antiviral agents.
Krishnaprasad Baby +6 more
doaj +2 more sources
mBio, 2021 Since its emergence in 2009, the pandemic H1N1 influenza A virus (IAV) has caused significant disease and mortality in humans. IAVs contain two envelope glycoproteins, the receptor-binding hemagglutinin (HA) and the receptor-destroying neuraminidase (NA).
Meiling Dai +10 more
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B Cell Responses against Influenza Viruses: Short-Lived Humoral Immunity against a Life-Long Threat
Viruses, 2021 Antibodies are critical for providing protection against influenza virus infections. However, protective humoral immunity against influenza viruses is limited by the antigenic drift and shift of the major surface glycoproteins, hemagglutinin and ...
Jenna J. Guthmiller +2 more
doaj +1 more source
Chemoenzymatic site-specific labeling of influenza glycoproteins as a tool to observe virus budding in real time. [PDF]
PLoS Pathogens, 2012 The influenza virus uses the hemagglutinin (HA) and neuraminidase (NA) glycoproteins to interact with and infect host cells. While biochemical and microscopic methods allow examination of the early steps in flu infection, the genesis of progeny virions ...
Maximilian Wei-Lin Popp +2 more
doaj +1 more source
Molecules, 2022 Screening of the antiviral and virucidal activities of ethanol extracts from plants endemic to the Republic of Korea revealed the inhibitory activity of a 70% ethanol extract of the whole plant of A. pseudoglehnii (APE) against influenza virus infection.
Subin Park +4 more
doaj +1 more source
Adaptation of the H7N2 Feline Influenza Virus to Human Respiratory Cell Culture
Viruses, 2022 During 2016–2017, the H7N2 feline influenza virus infected more than 500 cats in animal shelters in New York, USA. A veterinarian who had treated the cats became infected with this feline virus and showed mild respiratory symptoms. This suggests that the
Wataru Sekine +6 more
doaj +1 more source