Results 41 to 50 of about 13,620 (172)

The evolutionary pattern of glycosylation sites in influenza virus (H5N1) hemagglutinin and neuraminidase. [PDF]

PLoS ONE, 2012
Two glycoproteins, hemagglutinin (HA) and neuraminidase (NA), on the surface of influenza viruses play crucial roles in transfaunation, membrane fusion and the release of progeny virions.
Wentian Chen, Yaogang Zhong, Yannan Qin, Shisheng Sun, Zheng Li   +4 more
doaj   +1 more source

L-Ficolin Binds to the Glycoproteins Hemagglutinin and Neuraminidase and Inhibits Influenza A Virus Infection Both in vitro and in vivo [PDF]

Journal of Innate Immunity, 2012
L-ficolin, one of the complement lectins found in human serum, is a novel pattern recognition molecule that can specifically bind to microbial carbohydrates, thereby activating the lectin complement pathway and mounting a protective innate immune response. However, little is known about the role of L-ficolin during viral infections in vivo.
Qin, Pan, Haidan, Chen, Feng, Wang, Victor Tunje, Jeza, Wei, Hou, Yinglan, Zhao, Tian, Xiang, Ying, Zhu, Yuchi, Endo, Teizo, Fujita, Xiao-Lian, Zhang   +10 more
openaire   +2 more sources

VIRUS-SPECIFIC HUMORAL IMMUNE RESPONSE ISOTYPIC STRUCTURE IN ADULT PATIENTS HOSPITALIZED WITH INFLUENZA A

Инфекция и иммунитет, 2016
The aim of this investigation was a comparative analysis of isotypic structure of specific antiviral systemic humoral immune response in hospitalized patients with influenza caused by virus A(H3N2) or A(H1N1), including the A(H1N1)pdm09. Paired acute and
V. Z. Krivitskaya, A. A. Vasilieva, E. M. Voytsekhovskaya, E. R. Petrova, M. M. Pisareva, Zh. V. Buzitskaya, E. A. Elpaeva, A. A. Go, L. V. Voloshchuk, N. I. Lvov, T. D. Smirnova, A. A. Sominina   +11 more
doaj   +1 more source

A novel single virus infection system reveals that influenza virus preferentially infects cells in g1 phase. [PDF]

PLoS ONE, 2013
BackgroundInfluenza virus attaches to sialic acid residues on the surface of host cells via the hemagglutinin (HA), a glycoprotein expressed on the viral envelope, and enters into the cytoplasm by receptor-mediated endocytosis.
Ryuta Ueda, Tadao Sugiura, Shinichiro Kume, Akihiko Ichikawa, Steven Larsen, Hideaki Miyoshi, Hiroaki Hiramatsu, Yasuko Nagatsuka, Fumihito Arai, Yasuo Suzuki, Yoshio Hirabayashi, Toshio Fukuda, Ayae Honda   +12 more
doaj   +1 more source

A polyvalent virosomal influenza vaccine induces broad cellular and humoral immunity in pigs

Virology Journal, 2023
Background Influenza A virus (IAV) is endemic in pigs globally and co-circulation of genetically and antigenically diverse virus lineages of subtypes H1N1, H1N2 and H3N2 is a challenge for the development of effective vaccines.
Vanessa Haach, Ana Paula Almeida Bastos, Danielle Gava, Francisco Noé da Fonseca, Marcos Antônio Zanella Morés, Arlei Coldebella, Ana Cláudia Franco, Rejane Schaefer   +7 more
doaj   +1 more source

An Adenovirus-Vectored Influenza Vaccine Induces Durable Cross-Protective Hemagglutinin Stalk Antibody Responses in Mice

Viruses, 2017
Currently licensed vaccines against the influenza A virus (IAV) need to be updated annually to match the constantly evolving antigenicity of the influenza virus glycoproteins, hemagglutinin (HA), and neuramidiase (NA).
Eun Hye Kim, Gye-Yeong Han, Huan Nguyen
doaj   +1 more source

Evolutionary study and phylodynamic pattern of human influenza A/H3N2 virus in Indonesia from 2008 to 2010.

PLoS ONE, 2018
Influenza viruses are by nature unstable with high levels of mutations. The sequential accumulation of mutations in the surface glycoproteins allows the virus to evade the neutralizing antibodies.
Agustiningsih Agustiningsih, Hidayat Trimarsanto, Restuadi Restuadi, I Made Artika, Margaret Hellard, David Handojo Muljono   +5 more
doaj   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

Gene constellation of influenza A virus reassortants with high growth phenotype prepared as seed candidates for vaccine production. [PDF]

PLoS ONE, 2011
BACKGROUND: Influenza A virus vaccines undergo yearly reformulations due to the antigenic variability of the virus caused by antigenic drift and shift.
Andrew A Fulvini, Manojkumar Ramanunninair, Jianhua Le, Barbara A Pokorny, Jennifer Minieri Arroyo, Jeanmarie Silverman, Rene Devis, Doris Bucher   +7 more
doaj   +1 more source