Results 141 to 150 of about 4,203 (178)
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2014
The correlation between precise interactions of influenza A virus hemagglutinins with host cell surface glycans having terminal sialic acids and host range specificity has provoked the development of a high-throughput viral-receptor specificity assay.
Nongluk, Sriwilaijaroen, Yasuo, Suzuki
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The correlation between precise interactions of influenza A virus hemagglutinins with host cell surface glycans having terminal sialic acids and host range specificity has provoked the development of a high-throughput viral-receptor specificity assay.
Nongluk, Sriwilaijaroen, Yasuo, Suzuki
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Biochemistry, 1983
Castanospermine (1,6,7,8-tetrahydroxyoctahydroindolizine) is a plant alkaloid that inhibits alpha- and beta-glucosidase in fibroblast extracts [Saul, R., Chambers, J. P., Molyneux, R. J., & Elbein, A. D. (1983) Arch. Biochem. Biophys. 221, 593-597]. In the present study, castanospermine also proved to be a potent inhibitor of glycoprotein processing by
Y T, Pan +5 more
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Castanospermine (1,6,7,8-tetrahydroxyoctahydroindolizine) is a plant alkaloid that inhibits alpha- and beta-glucosidase in fibroblast extracts [Saul, R., Chambers, J. P., Molyneux, R. J., & Elbein, A. D. (1983) Arch. Biochem. Biophys. 221, 593-597]. In the present study, castanospermine also proved to be a potent inhibitor of glycoprotein processing by
Y T, Pan +5 more
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Immune recognition of influenza hemagglutinin as a viral and a neo-self-antigen
Immunologic Research, 1998To analyze mechanisms governing tolerance and autoimmunity to self-antigens, we have generated lineages of transgenic mice that express the influenza virus PR8 hemagglutinin (HA) as a neo-self-antigen. By comparing the HA-specific T and B cell responses that can be induced in HA Tg mice with those that are induced in non-Tg (BALB/c) mice, the ...
A J, Caton, D M, Cerasoli, F F, Shih
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Formation of noninfectious viral hemagglutinins in ascites tumor cells
Virology, 1960Abstract The replication of influenza virus in two strains of ascites tumor cells, Ehrlich's and Krebs 2, in vitro and in the mouse peritoneum was compared with growth of this virus in roller tube suspensions of minced chorioallantoic membrane. Extended incubation of tumor cells with influenza or Newcastle viruses resulted in a progressive cell ...
Eaton, M D, Jewell, M, Scala, A R
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Virology
Two biological types of influenza virus are known and distinguished by the structure of the surface glycoprotein, hemagglutinin (HA). The noninfectious virions contain the uncleaved HA0 (80 kDa), whereas the infectious type have a cleaved form of two subunits, HA1 (55 kDa) and HA2 (25 kDa).
O.P. Zhirnov, A.I. Chernyshova
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Two biological types of influenza virus are known and distinguished by the structure of the surface glycoprotein, hemagglutinin (HA). The noninfectious virions contain the uncleaved HA0 (80 kDa), whereas the infectious type have a cleaved form of two subunits, HA1 (55 kDa) and HA2 (25 kDa).
O.P. Zhirnov, A.I. Chernyshova
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Canadian Journal of Microbiology, 1971
Purified Sindbis virus is split into two components upon treatment with ether. These are (a) a hemagglutinin which sediments at 55 S and is non-infectious. This fraction was shown to be devoid of phospholipid and to contain the envelope structural protein of the virion; (b) a fraction sedimenting at 135 S, which is devoid of RNA, but contains viral ...
B, Arif, P, Faulkner
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Purified Sindbis virus is split into two components upon treatment with ether. These are (a) a hemagglutinin which sediments at 55 S and is non-infectious. This fraction was shown to be devoid of phospholipid and to contain the envelope structural protein of the virion; (b) a fraction sedimenting at 135 S, which is devoid of RNA, but contains viral ...
B, Arif, P, Faulkner
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Journal of Virology
ABSTRACT Seasonal influenza vaccines provide mostly strain-specific protection due to the elicitation of antibody responses focused on evolutionarily plastic antigenic sites in the hemagglutinin head domain. To direct the humoral response toward more conserved epitopes, we generated an influenza virus particle where ...
Cait E. Hamele +9 more
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ABSTRACT Seasonal influenza vaccines provide mostly strain-specific protection due to the elicitation of antibody responses focused on evolutionarily plastic antigenic sites in the hemagglutinin head domain. To direct the humoral response toward more conserved epitopes, we generated an influenza virus particle where ...
Cait E. Hamele +9 more
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Virus Research, 1985
We have analyzed the pronase-derived glycopeptides of the hemagglutinin glycoproteins expressed from SV40 vectors carrying cloned cDNA copies of the HA gene and of HA isolated from influenza virions (A/Jap/305/57). The glycopeptides derived from he HA glycoprotein obtained from cloned genes were heterogeneous, ranging in size from 3800 to 2800 daltons.
S, Basak, M, Tomana, R W, Compans
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We have analyzed the pronase-derived glycopeptides of the hemagglutinin glycoproteins expressed from SV40 vectors carrying cloned cDNA copies of the HA gene and of HA isolated from influenza virions (A/Jap/305/57). The glycopeptides derived from he HA glycoprotein obtained from cloned genes were heterogeneous, ranging in size from 3800 to 2800 daltons.
S, Basak, M, Tomana, R W, Compans
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Identification of immunodominant CD8 epitope in the stalk domain of influenza B viral hemagglutinin
Biochemical and Biophysical Research Communications, 2018Human infections by type B influenza virus constitute about 25% of all influenza cases. The viral hemagglutinin is comprised of two subunits, HA1 and HA2. While HA1 is constantly evolving in an unpredictable fashion, the HA2 subunit is highly conserved, making it a potential candidate for a universal vaccine. However, immunodominant epitopes in the HA2
Abenaya, Muralidharan +8 more
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Chemical Biology & Drug Design
ABSTRACTA series of [2,3]‐isoxazoles and pyrazole annulated with the A‐ring of lupane, oleanane, and ursane type triterpenoids was synthesized and screened for antiviral activity. It was found that 28‐oxo‐allobetulone isoxazole 4 with IC50 7.3 μM (SI 86) and pyrazole 5 with IC50 62.1 μM (SI 10) demonstrated a high inhibitory activity against Flu A ...
Irina E. Smirnova +5 more
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ABSTRACTA series of [2,3]‐isoxazoles and pyrazole annulated with the A‐ring of lupane, oleanane, and ursane type triterpenoids was synthesized and screened for antiviral activity. It was found that 28‐oxo‐allobetulone isoxazole 4 with IC50 7.3 μM (SI 86) and pyrazole 5 with IC50 62.1 μM (SI 10) demonstrated a high inhibitory activity against Flu A ...
Irina E. Smirnova +5 more
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