Results 141 to 150 of about 6,670 (185)

Memory T and B cells with recognition of avian influenza hemagglutinins are poorly responsive to existing seasonal influenza vaccines

open access: yes
Gonelli CA   +12 more
europepmc   +1 more source

Immunologic Studies of Purified Viral Hemagglutinin

The Journal of Immunology, 1964
Summary A hemagglutinin fraction (HAF) of influenza A (PR8) virus, purified by sucrose density gradient centrifugation and shown to be highly homogenous by analytical ultracentrifugation, electron microscopy and a gel diffusion test, was used as an immunizing antigen in these studies.
M J, TONG, J, FONG
openaire   +2 more sources

Influenza Viral Hemagglutinin Peptide Inhibits Influenza Viral Entry by Shielding the Host Receptor

ACS Infectious Diseases, 2016
Influenza viral infection of the host begins by the attachment of viral hemagglutinin to a cell surface receptor. In the current study, a hemagglutinin fragment peptide library was screened using an H5N1 recombinant pseudotyped viral system. One peptide, designated HA-pep25, showed effective antiviral activity against both human and avian influenza ...
Qing, Chen, Ying, Guo
openaire   +2 more sources

Viral hemagglutinin augments peptide‐specific cytotoxic T cell responses

European Journal of Immunology, 1993
AbstractIn attempt to increase the induction of peptide‐specific cytolytic T cells (CTL) we investigated the effect of the Newcastle disease virus (NDV) hemagglutinin‐neuraminidase (HN) gene product on the activation of peptide‐specific CTL. Spleen cells of CH3 mice immunized against the influenza nucleoprotein peptide 50–63 (NP 50–63) were ...
C, Ertel   +4 more
openaire   +2 more sources

A survey for hemagglutinins in viral hepatitis

The American Journal of Medicine, 1959
Abstract Two recently described agglutination tests have been assessed for their possible value in studies concerned with human viral hepatitis. The rhesus erythrocyte agglutination test was not found to yield sufficiently significant results to make it a useful test.
Robert W. McCollum   +3 more
openaire   +1 more source

Expression of viral hemagglutinin on the surface ofE. coli

Klinische Wochenschrift, 1988
Expression of a foreign protein molecule on the E. coli bacterial surface has been achieved through hybrid plasmid construction of fusion proteins using outer membrane protein ompA as a carrier system. Influenza virus hemagglutinin fusion proteins of this character have been shown to become integrated into the bacterial outer membrane and to expose ...
S, Pistor, G, Hobom
openaire   +2 more sources

Direct role of viral hemagglutinin in B-cell mitogenesis by influenza viruses

Journal of Virology, 1987
The mitogenic activity of influenza virus is a function of the hemagglutinin (HA) molecule. Purified HA is mitogenic for murine B lymphocytes but not T lymphocytes. Furthermore, like the intact virus, HA of the H2 (but not H3) subtype is mitogenic only for B cells expressing the class II major histocompatibility complex glycoprotein I-E.
P, Poumbourios   +5 more
openaire   +2 more sources

A Simple Viral Neuraminidase-Based Detection for High-Throughput Screening of Viral Hemagglutinin–Host Receptor Specificity

2014
The correlation between precise interactions of influenza A virus hemagglutinins with host cell surface glycans having terminal sialic acids and host range specificity has provoked the development of a high-throughput viral-receptor specificity assay.
Nongluk, Sriwilaijaroen, Yasuo, Suzuki
openaire   +2 more sources

Castanospermine inhibits the processing of the oligosaccharide portion of the influenza viral hemagglutinin

Biochemistry, 1983
Castanospermine (1,6,7,8-tetrahydroxyoctahydroindolizine) is a plant alkaloid that inhibits alpha- and beta-glucosidase in fibroblast extracts [Saul, R., Chambers, J. P., Molyneux, R. J., & Elbein, A. D. (1983) Arch. Biochem. Biophys. 221, 593-597]. In the present study, castanospermine also proved to be a potent inhibitor of glycoprotein processing by
Y T, Pan   +5 more
openaire   +2 more sources

Immune recognition of influenza hemagglutinin as a viral and a neo-self-antigen

Immunologic Research, 1998
To analyze mechanisms governing tolerance and autoimmunity to self-antigens, we have generated lineages of transgenic mice that express the influenza virus PR8 hemagglutinin (HA) as a neo-self-antigen. By comparing the HA-specific T and B cell responses that can be induced in HA Tg mice with those that are induced in non-Tg (BALB/c) mice, the ...
A J, Caton, D M, Cerasoli, F F, Shih
openaire   +2 more sources

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