Results 81 to 90 of about 4,203 (178)

Advances in Therapeutic Antibody Discovery and Development Targeting G Protein‐Coupled Receptors

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Catherine J. Hutchings, Serbülent Ünsal, Mathieu Rappas, Matthew Barnes, Maria Waldhoer, Ben Holland, Martin Culka   +6 more
wiley   +1 more source

Hydroxypropyl Cellulose Enhances Immune Responses to the Current Seasonal Influenza Vaccine in Mice

Microbiology and Immunology, Volume 70, Issue 2, Page 68-79, February 2026.
ABSTRACT Influenza A and B viruses cause annual epidemics and continue to pose global public health concerns. The most effective approach to preventing or mitigating the severity of influenza is vaccination. Inactivated split influenza HA vaccines are commonly used worldwide due to their strong safety profile and broad range of target groups; however ...
Nantaporn Kaewaroon, Sara Yoshimoto, Luthfi Muawan, Shintaro Shichinohe, Tokiko Watanabe   +4 more
wiley   +1 more source

Emergence, spread, and impact of high‐pathogenicity avian influenza H5 in wild birds and mammals of South America and Antarctica

Conservation Biology, Volume 40, Issue 1, February 2026.
Abstract The currently circulating high‐pathogenicity avian influenza (HPAI) virus of the subtype H5 causes variable illness and death in wild and domestic birds and mammals, as well as in humans. This virus evolved from the Goose/Guangdong lineage of the HPAI H5 virus, which emerged in commercial poultry in China in 1996, spilled over into wild birds,
Thijs Kuiken, Ralph Eric Thijl Vanstreels, Ashley Banyard, Lineke Begeman, Andrew C. Breed, Meagan Dewar, Ruben Fijn, Patricia Pereira Serafini, Marcela Uhart, Michelle Wille   +9 more
wiley   +1 more source

LAG‐3+ Regulatory T Cells Suppress Effector Function of T Cells and Allow Their Proliferation Into Regulatory T Cells

Immunology, Volume 177, Issue 2, Page 317-328, February 2026.
LAG‐3+ regulatory T cells suppress the effector but not the proliferative response of naïve cognate antigen‐specific CD4+ T cells in vivo. The suppressed T cells display upregulation of immune checkpoints and downregulation of pro‐inflammatory pathways with enhanced TCR signaling and reduced oxidative metabolism.
Avijit Dutta, Shi‐Chuen Miaw, Tse‐Ching Chen, Chia‐Shiang Chang, Yu‐Lin Huang, Yung‐Chang Lin, Chun‐Yen Lin, Ching‐Tai Huang   +7 more
wiley   +1 more source

Viral Hemagglutinin Purification [PDF]

, 2020
openaire   +1 more source

Viral hemagglutinin-esterases: Mediators of dynamic virion-glycan interactions

, 2011
The sialic acids (Sias), a diverse family of 9-carbon sugars, are among the most important molecules of life. Commonly occurring as terminal residues of glycans on proteins and lipids, they are key elements of glycotopes of cellular lectins and there is accumulating evidence for them to act as chemical messengers in cell recognition and signaling ...
openaire   +2 more sources

Near real-time data on the human neutralizing antibody landscape to influenza virus to inform vaccine-strain selection in September 2025. [PDF]

Virus Evol
Kikawa C, Huddleston J, Loes AN, Turner SA, Lee J, Barr IG, Cowling BJ, Englund JA, Greninger AL, Harvey R, Hasegawa H, Ho F, Lacombe K, Leung NHL, Lewis NS, Peck H, Watanabe S, Smith DJ, Bedford T, Bloom JD.   +19 more
europepmc   +2 more sources

A locally administered single-cycle influenza vaccine expressing a non-fusogenic stabilized hemagglutinin stimulates strong T-cell and neutralizing antibody immunity. [PDF]

J Virol
Sadler HL, Rijal P, Tan TK, Townsend ARM.   +3 more
europepmc   +1 more source

Detection of Lineage IV Peste Des Petits Ruminants Virus by RT-qPCR Assay via Targeting the Hemagglutinin Gene. [PDF]

Viruses
Xu J, Wang Q, Yu J, Wang Y, Li H, Li L, Bao J, Wang Z.   +7 more
europepmc   +1 more source

A Naked Lyophilized mRNA Vaccine Against Seasonal Influenza, Administered by Jet Injection, Provides a Robust Response in Immunized Mice. [PDF]

Vaccines (Basel)
Sharabrin SV, Krasnikova SI, Kisakov DN, Borgoyakova MB, Yakovlev VA, Tigeeva EV, Starostina EV, Litvinova VR, Kisakova LA, Vahitov DI, Makarova KP, Volosnikova EA, Ivanova KI, Bondar AA, Rudometova NB, Rudometov AP, Ilyichev AA, Karpenko LI.   +17 more
europepmc   +1 more source