Results 21 to 30 of about 39,654 (286)

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

Nature Immunology, 2018
The present vaccine against influenza virus has the inevitable risk of antigenic discordance between the vaccine and the circulating strains, which diminishes vaccine efficacy.
M. Kanekiyo, M. Joyce, Rebecca A. Gillespie, J. Gallagher, Sarah F. Andrews, Hadi M. Yassine, A. Wheatley, Brian E. Fisher, D. Ambrozak, A. Creanga, K. Leung, E. Yang, Seyhan Boyoglu-Barnum, I. Georgiev, Y. Tsybovsky, Madhu Prabhakaran, H. Andersen, W. Kong, U. Baxa, Kathryn L. Zephir, J. Ledgerwood, R. Koup, P. Kwong, Audray K. Harris, A. McDermott, J. Mascola, B. Graham   +26 more
semanticscholar   +1 more source

Structural and Functional Aspects of G-Quadruplex Aptamers Which Bind a Broad Range of Influenza A Viruses

Biomolecules, 2020
An aptamer is a synthetic oligonucleotide with a unique spatial structure that provides specific binding to a target. To date, several aptamers to hemagglutinin of the influenza A virus have been described, which vary in affinity and strain specificity ...
Anastasia A. Novoseltseva, Nikita M. Ivanov, Roman A. Novikov, Yaroslav V. Tkachev, Dmitry A. Bunin, Alexandra S. Gambaryan, Vadim N. Tashlitsky, Alexander M. Arutyunyan, Alexey M. Kopylov, Elena G. Zavyalova   +9 more
doaj   +1 more source

Purification, Biochemical Characterization, and Bioactive Properties of a Lectin Purified from the Seeds of White Tepary Bean (Phaseolus Acutifolius Variety Latifolius)

Molecules, 2011
The present work shows the characterization of Phaseolus acutifolius variety latifolius, on which little research has been published, and provides detailed information on the corresponding lectin.
Marco A. Becerril-Flores, José Gutiérrez-Salinas, Clara Zúñiga-Pérez, José Roberto Villagómez-Ibarra, Eduardo Madrigal-Santillán, Gerardo Álvarez-Manilla, José A. Morales-González, Ana María Guzmán-Partida, Francisco Javier Soto-Cordova, Carmen Valadez-Vega   +9 more
doaj   +1 more source

Influence of elastin-like polypeptide and hydrophobin on recombinant hemagglutinin accumulations in transgenic tobacco plants. [PDF]

PLoS ONE, 2014
Fusion protein strategies are useful tools to enhance expression and to support the development of purification technologies. The capacity of fusion protein strategies to enhance expression was explored in tobacco leaves and seeds.
Hoang Trong Phan, Bettina Hause, Gerd Hause, Elsa Arcalis, Eva Stoger, Daniel Maresch, Friedrich Altmann, Jussi Joensuu, Udo Conrad   +8 more
doaj   +1 more source

Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin [PDF]

, 2014
Influenza viruses continuously undergo antigenic changes with gradual accumulation of mutations in hemagglutinin (HA) that is a major determinant in subtype specificity.
Cho, Ki Joon, Hong, Kwang W, Kim, Kyung Hyun, Kim, Se-Ho, Kim, Sella, Lee, Ji-Hye, Saelens, Xavier, Seok, Jong Hyeon   +7 more
core   +4 more sources

Gluing up hemagglutinin [PDF]

Science, 2017
Influenza The morbidity and economic tolls of influenza virus are huge, regardless of its capacity to kill. Vaccines and therapies to control this persistent threat are limited. In structural studies, Kadam and Wilson show how the broad-spectrum antiviral arbidol inactivates viral hemagglutinin (HA).
openaire   +2 more sources

A carboxy-terminal trimerization domain stabilizes conformational epitopes on the stalk domain of soluble recombinant hemagglutinin substrates.

PLoS ONE, 2012
Recently, a new class of broadly neutralizing anti-influenza virus antibodies that target the stalk domain of the viral hemagglutinin was discovered. As such, induction, isolation, characterization, and quantification of these novel antibodies has become
Florian Krammer, Irina Margine, Gene S Tan, Natalie Pica, Jens C Krause, Peter Palese   +5 more
doaj   +1 more source

The production and development of H7 Influenza virus pseudotypes for the study of humoral responses against avian viruses [PDF]

, 2013
In recent years, high pathogenicity avian influenza (HPAI) virus, H5N1, low pathogenicity avian influenza (LPAI) virus, H9N2, and both HPAI and LPAI H7 viruses have proved devastating for the affected economies reliant on poultry industry, and have posed
Böttcher-Frieberthäuser, Eva, Cattoli, Giovanni, Ferrara, Francesca, Molesti, Eleonora, Temperton, Nigel, Terregino, Calogero   +5 more
core   +3 more sources

HEMAGGLUTINATION AND ANTIGENIC PROPERTIES OF AVIBACTERIUM PARAGALLINARUM ISOLATES RECOVERED IN THE RUSSIAN FEDERATION AND REPUBLIC OF BELARUS

Ветеринария сегодня, 2019
The paper demonstrates examination results of antigenic properties of Avibacterium paragallinarum reference strain and ten isolates thereof recovered in the Russian Federation and Republic of Belarus.
A. V. Potehin, V. A. Yevgrafova, D. B. Andreychuk   +2 more
doaj   +1 more source

Cross-protection between antigenically distinct H1N1 swine influenza viruses from Europe and North America [PDF]

, 2011
Background An avian-like H1N1 swine influenza virus (SIV) is enzootic in swine populations of Western Europe. The virus is antigenically distinct from H1N1 SIVs in North America that have a classical swine virus-lineage H1 hemagglutinin, as does the ...
Brookes, Brown, Brown, Brown, Brownlee, Dürrwald, Garten, Grebe, Guan, Hinshaw, Hofshagen, Itoh, Kingsford, Kyriakis, Lange, Maurer-Stroh, Miller, Olsen, Olsen, Pensaert, Reed, Sandbulte, Scholtissek, Smith, Takemae, Van Reeth, Van Reeth, Van Reeth, Van Reeth, Van Reeth, Weingartl   +30 more
core   +1 more source