Results 11 to 20 of about 39,654 (286)
Polymer-stabilized sialylated nanoparticles : synthesis, optimization, and differential binding to influenza hemagglutinins [PDF]
Biomacromolecules, 2020 During influenza infection, hemagglutinins (HAs) on the viral surface bind to sialic acids on the host cell's surface. While all HAs bind sialic acids, human influenza targets terminal α2,6 sialic acids and avian influenza targets α2,3 sialic acids.
Baker, Alexander +3 more
core +3 more sources
PLoS ONE, 2014 Binding of influenza viruses to target cells is mediated by the viral surface protein hemagglutinin. To determine the presence of binding sites for influenza A viruses on cells and tissues, soluble hemagglutinins of the H7 and H9 subtype were generated ...
Anne-Kathrin Sauer +8 more
doaj +2 more sources
Neutralizing immune responses induced by oligomeric H5N1-hemagglutinins from plants
Veterinary Research, 2017 Plant-based transient expression is an alternative platform to produce hemagglutinin-based subunit vaccines. This production system provides not only fast and effective response in the context of a pandemic but also enables the supply of big volume ...
Hoang Trong Phan +5 more
doaj +2 more sources
The Porphyromonas gingivalis hemagglutinins HagB and HagC are major mediators of adhesion and biofilm formation [PDF]
Molecular Oral Microbiology, 2016 Porphyromonas gingivalis is a bacterium associated with chronic periodontitis that possesses a family of genes encoding hemagglutinins required for heme acquisition.
Connolly, E. +5 more
core +2 more sources
Cell Reports, 2017 Antibodies that target both group 1 and group 2 influenza A viruses are valuable for therapeutic and vaccine development, but only a few have been reported to date.
Shanshan Lang +5 more
doaj +2 more sources
PLoS Pathogens, 2010 As targets of adaptive immunity, influenza viruses are characterized by the fluidity with which they respond to the selective pressure applied by neutralizing antibodies.
Taia T Wang +6 more
doaj +2 more sources
Identification of a novel inhibitor targeting influenza A virus group 2 hemagglutinins.
Antiviral Research, 2021 Influenza A virus (IAV) causes seasonal epidemics and occasional but devastating pandemics, which are major public health concerns. The putative antiviral therapeutics are useful for the treatment of influenza, however, the emerging resistant strains ...
Ruikun Du +5 more
semanticscholar +1 more source
Cell Host and Microbe, 2020 Summary Hemagglutinins (HAs) from human influenza viruses adapt to bind α2-6-linked sialosides, overcoming a receptor-defined species barrier distinct from the α2-3 specificity of avian virus progenitors.
A. Thompson +10 more
semanticscholar +1 more source
Evolutionarily conserved amino acids in MHC-II mediate bat influenza A virus entry into human cells.
PLoS Biology, 2023 The viral hemagglutinins of conventional influenza A viruses (IAVs) bind to sialylated glycans on host cell surfaces for attachment and subsequent infection. In contrast, hemagglutinins of bat-derived IAVs target major histocompatibility complex class II
Okikiola M Olajide +10 more
doaj +1 more source
Detection of H1 Swine Influenza A Virus Antibodies in Human Serum Samples by Age Group
Emerging Infectious Diseases, 2020 Most H1 influenza A viruses (IAVs) of swine are derived from past human viruses. As human population immunity against these IAVs gradually decreases, the risk of reintroduction to humans increases. We examined 549 serum samples from persons 0–97 years of
Elien Vandoorn +5 more
doaj +1 more source