Results 31 to 40 of about 604 (128)
, 2003 Hematogones (B-lymphocyte progenitor-precursor cells) are normal bone marrow constituents which are morphologically distinct lymphoid cells with homogeneous, condensed uniform nuclear chromatin and scant cytoplasm.
Kara, Abdurrahman +3 more
core +1 more source
Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report
Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan +6 more
wiley +1 more source
Light-chain-restricted hematogones are a potential diagnostic pitfall for B-cell lymphoma
Indian Journal of Pathology and MicrobiologyBackground and Objective: The aim is to differentiate light-chain-restricted hematogones (LCR-HGs) from B-cell lymphoma. Materials and Methods: We identified eight patients who underwent bone marrow (BM) flow cytometry (FLC) diagnosis or evaluation for ...
Xiaofeng Yang +2 more
doaj +1 more source
Cancer Medicine, Volume 15, Issue 3, March 2026.ABSTRACT Background The level of measurable residual disease (MRD) is one of the most important features correlating depths of response and long‐term outcomes in multiple myeloma (MM) and MRD evaluation is currently the gold standard tool for assessing treatment response.
Stefania Oliva +37 more
wiley +1 more source
, 1999 Hematogones are benign immature B cells that commonly populate the bone marrow of children. Their presence has been noted to interfere with the flowcytometric analysis of cases of suspected acute lymphoblastic leukemia (ALL) because their ...
Susan L. Hasegawa +2 more
core +1 more source
Experimental Hematology & Oncology, 2018 Background Immune checkpoint blockade (ICB) is becoming an increasingly prevalent strategy in the clinical realm of cancer therapeutics. With more patients being administered ICB for a host of tumor types, the scope of adverse events associated with ...
D. E. Meyers +5 more
doaj +1 more source
Cytometry Part B: Clinical Cytometry, Volume 110, Issue 2, Page 77-91, March 2026.Abstract Minimal/measurable residual disease detection is routinely performed as part of post‐diagnostic treatment plans for many types of cancer, for which multiparameter flow cytometry is one possible modality frequently used. We propose a machine learning approach for binary prediction of minimal residual disease status with flow cytometry data. Our
Wikum Dinalankara +5 more
wiley +1 more source
HemaSphere, Volume 10, Issue 2, February 2026.Abstract Flow cytometry‐based measurable residual disease (MRD) testing is routinely used in acute myeloid leukemia (AML), but methodologies need refinement to optimize assay characteristics. Here, we examined 1215 adults with AML or myelodysplastic syndrome/AML allografted in morphologic remission to study how the type(s) of leukemic blasts and degree/
Calvin M. Le +8 more
wiley +1 more source
Healthcare Technology Letters, Volume 13, Issue 1, January/December 2026.We propose an automated framework for early detection of acute lymphoblastic leukaemia (ALL) and its subtypes using 20,000 peripheral blood smear images. The method combines Vahadane‐based colour normalization, deep neural network feature extraction, and a stacking ensemble classifier to accurately distinguish ALL from haematogones and identify disease
Faysal Ahmmed +3 more
wiley +1 more source
FIGURE 1 from Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia
, 2023 Sig15 is highly expressed in B-ALL and additional hematologic malignancies. A, Relative SIG15 expression. B-ALL (N = 147; P = 3.6 × 10−19) and AML (N = 542; P = 2.0 × 10−9) samples showed higher SIG15 than normal PBMC samples (N = 74).
Christopher C. Porter (16556935) +17 more
core +1 more source