Results 101 to 110 of about 99,201 (311)

PET-CT in Clinical Adult Oncology: I. Hematologic Malignancies

, 2022
PET-CT is an advanced imaging modality with many oncologic applications, including staging, assessment of response to therapy, restaging and evaluation of suspected recurrence.
Fine, Gabriel C., Morton, Kathryn A., Ahmed Ebada Salem, Richard H. Wiggins, Wiggins, Richard H., Koppula, Bhasker R., Gabriel C. Fine, Hoffman, John M., Covington, Matthew F., John M. Hoffman, Kathryn A. Morton, Matthew F. Covington, Harsh R. Shah, Shah, Harsh R., Bhasker R. Koppula, Salem, Ahmed Ebada   +15 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

The TGFβ type I receptor kinase inhibitor vactosertib in combination with pomalidomide in relapsed/refractory multiple myeloma: a phase 1b trial

Nature Communications
Functional blockade of the transforming growth factor-beta (TGFβ) signalling pathway improves the efficacy of cytotoxic and immunotherapies. Here, we conducted a phase 1b study (ClinicalTrials.gov., NCT03143985) to determine the primary endpoints of ...
Ehsan Malek, Priyanka S. Rana, Muthulekha Swamydas, Michael Daunov, Masaru Miyagi, Elena Murphy, James J. Ignatz-Hoover, Leland Metheny, Seong Jin Kim, James J. Driscoll   +9 more
doaj   +1 more source

Carbamazepine and Hematological Malignancies

The Turkish Journal of Hematology, 2013
Received/Gelis tarihi : May 1, 2013 Accepted/Kabul tarihi : June 10, 2013 To the Editor, The letter entitled “Carbamazepine and Multiple Myeloma: Possible Interaction”, written by Gunaldi et al. [1] and published in one of the recent issues of your journal, was quite interesting. We would like to emphasize some points about that letter. In the reported
İrfan Yavaşoğlu, Gökhan Sargın, Aslı Demirbulat   +2 more
openaire   +3 more sources

Racial and ethnic disparities in hematologic malignancies

, 2017
Racial and ethnic disparities in patients with solid malignancies have been well documented. Less is known about these disparities in patients with hematologic malignancies. With the advent of novel chemotherapeutics and targeted molecular, cellular, and
Stephanie J. Lee, Kedar Kirtane
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Low Dose of IL‐2 Application for Graft‐Versus‐Host Disease Prophylaxis Following Haploidentical Stem Cell Transplantation

MedComm
Graft‐versus‐host disease (GVHD) are still key obstacles of haploidentical transplantation. Interleukin‐2 (IL‐2) could promote natural killer (NK) cells and T‐regulatory cells (Tregs) cells expansion in vitro and in vivo.
Zheng‐Li Xu, Meng Lv, Xing‐Xing Yu, Yi‐Yang Ding, Ting‐Ting Han, Hai‐Xia Fu, Yuan‐Yuan Zhang, Xiao‐Dong Mo, Yu‐Qian Sun, Lan‐Ping Xu, Xiao‐Hui Zhang, Yu Wang, Xiao‐Jun Huang, Xiang‐Yu Zhao   +13 more
doaj   +1 more source

CCR5 Signaling Promotes Murine and Human Hematopoietic Regeneration following Ionizing Radiation

Stem Cell Reports, 2019
Summary: Hematopoietic stem and progenitor cells (HSPCs) depend on regulatory cytokines from the marrow microenvironment. From an unbiased cytokine screen of murine marrow supernatants, we identified C-C motif chemokine ligand 5 (CCL5) as an endothelial ...
Sadhna O. Piryani, Angel Y.F. Kam, Uyen T. Vu, Nelson J. Chao, Phuong L. Doan   +4 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source