Results 281 to 290 of about 99,201 (311)
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Hematological Malignancies and Fertility
2020In the last decades, survival rate of hematological malignancies has been significantly improved and sparing reproductive potential after treatment has become one of the goals in both male and female patients. A comprehensive consultation with reproductive specialists before the onset of any kind of cancer treatment procedure is an essential issue ...
Zehra Narli, Ozdemir +1 more
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Antibodies and Hematologic Malignancies
The Cancer Journal, 2008Over the last decade, monoclonal antibody therapy has transformed treatment of many hematologic malignancies. Optimizing the use of the existing agents and developing new agents will be critical to continuing these advances. This review summarizes existing data, new agents under investigation, and areas in which progress needs to be made in ...
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Immunotherapy of Hematologic Malignancy
Hematology, 2003AbstractOver the past few years, improved understanding of the molecular basis of interactions between antigen presenting cells and effector cells and advances in informatics have both led to the identification of many candidate antigens that are targets for immunotherapy.
Heslop, Helen E. +2 more
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Chromothripsis in hematologic malignancies
Experimental HematologyChromotrypsis, a phenomenon resulting from catastrophic mitotic errors and genomic instability, is defined by the occurrence of multiple DNA double-strand breaks in one or more chromosomes, subsequently subject to error-prone repair mechanisms. This unique process results in extensive rearrangements in the affected chromosomes, leading to loss of tumor
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Thioredoxin and Hematologic Malignancies
2014Thioredoxin (Trx) is an inflammation-inducible small oxidoreductase protein ubiquitously expressed in all organisms. Trx acts both intracellularly and extracellularly and is involved in a wide range of physiological cellular responses. Inside the cell, Trx alleviates oxidative stress by scavenging reactive oxygen species (ROS), regulates a variety of ...
Ningfei, An, Yubin, Kang
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Expert Review of Hematology, 2011
Pain is frequently experienced by patients with hematological malignancies, although it often receives little attention. Different underlying causes and mechanisms may sustain several pain syndromes in hematological malignant patients. Pain may be due to disease itself, to disease-related complications, to iatrogenic causes or may be associated with ...
Pasquale, Niscola +13 more
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Pain is frequently experienced by patients with hematological malignancies, although it often receives little attention. Different underlying causes and mechanisms may sustain several pain syndromes in hematological malignant patients. Pain may be due to disease itself, to disease-related complications, to iatrogenic causes or may be associated with ...
Pasquale, Niscola +13 more
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Gemcitabine in hematologic malignancies
Current Opinion in Oncology, 2001Gemcitabine is a pyrimidine analogue that showed significant activity in solid malignancies. Gemcitabine acts by inhibiting DNA synthesis through chain termination and ribonucleotide reductase inhibition. During initial phase I and II studies, gemcitabine had a low toxicity profile and was well tolerated as a single agent and in combination therapy ...
C, Nabhan, N, Krett, V, Gandhi, S, Rosen
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Hematologic Malignancies in Pregnancy
Obstetrics and Gynecology Clinics of North America, 2005Hematologic malignancies complicating pregnancy are uncommon, but a delay in diagnosis or treatment can mean the difference between life and death. It is the responsibility of the obstetrician, nurse-midwife, or nurse practitioner to maintain a high index of suspicion when patients present with unexplained lymphadenopathy or protracted constitutional ...
Timothy J, Hurley +2 more
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Infections in Hematologic Malignancy
Infection Control & Hospital Epidemiology, 1986Two decades have elapsed since the first detailed studies were undertaken to determine which factors were associated with an increased incidence of life-threatening sepsis during the treatment of leukemia and lymphoma. The state of granulocytopenia is now acknowledged to be the major factor predisposing to infection and accordingly, attention has ...
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When hematologic malignancies meet COVID-19 in the United States: Infections, death and disparities
Blood Reviews, 2021Quanqiu Wang, Nathan A Berger, Rong Xu
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