Results 91 to 100 of about 187,916 (412)

Oscillations in a white blood cell production model with multiple differentiation stages [PDF]

J Math Biol. 2019, 2018
In this work we prove occurrence of a super-critical Hopf bifurcation in a model of white blood cell formation structured by three maturation stages. We provide an explicit analytical expression for the bifurcation point depending on model parameters.
arxiv   +1 more source

SRSF2 Is Essential For Hematopoiesis and Its Mutations Dysregulate Alternative RNA Splicing In MDS [PDF]

, 2013
Myelodysplastic syndromes (MDS) are a group of neoplasms that are ineffective in generating multiple lineages of myeloid cells and have various risks to progress to acute myeloid leukemia.
Chen, Liang, Dekelver, Russell, Fu, Xiang-Dong, Heuser, Michael, Komeno, Yukiko, Lin, Leo, Monterroza, Dora D, Qiu, Jinsong, Thol, Felicitas, Xu, YiJun, Zhang, Dong-Er   +10 more
core  

Global Stability Analysis of Healthy Situation for a Coupled Model of Healthy and Cancerous Cells Dynamics in Acute Myeloid Leukemia [PDF]

, 2017
In this paper we aim to study the global stability of a coupled model of healthy and cancerous cells dynamics in healthy situation of Acute Myeloid Leukemia.
Chakir, M., Tadjine, M., Zenati, A.
core   +1 more source

Crustacean hematopoiesis

Developmental & Comparative Immunology, 2016
Crustacean hemocytes are important mediators of immune reactions, and the regulation of hemocyte homeostasis is of utmost importance for the health of these animals. This review discusses the current knowledge on the lineages, synthesis and differentiation of hemocytes in crustaceans.
openaire   +4 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Clonal Hematopoiesis–Driver DNMT3A Mutations Alter Immune Cells in Heart Failure

Circulation Research, 2020
Supplemental Digital Content is available in the text. Rationale: Clonal hematopoiesis driven by mutations of DNMT3A (DNA methyltransferase 3a) is associated with increased incidence of cardiovascular disease and poor prognosis of patients with chronic ...
W. Abplanalp, S. Cremer, D. John, Jedrzej Hoffmann, B. Schuhmacher, M. Merten, M. Rieger, M. Vasa-Nicotera, A. Zeiher, S. Dimmeler   +9 more
semanticscholar   +1 more source

Perinephric extramedullary hematopoiesis [PDF]

Kidney International, 2012
A 67-year-old male presented with persistent abdominal discomfort 2 years post-splenectomy carried out for myelofibrosis, complicated by anemia and thrombocytopenia. He was transfusion dependent at the time of presentation. Physical examination revealed bilateral loin masses. Contrast-enhanced multidetector computed tomography of the abdomen (Figure 1)
Ashish Khandelwal, Ankur Gupta, Kanika Khandelwal   +2 more
openaire   +3 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Differentiating erythroblasts adapt to mechanical stimulation by upregulation of cholesterol biosynthesis via S1P/SREBP-induced HMGCR expression

Scientific Reports
Understanding how mechanical stress affects erythropoiesis is crucial to produce transfusable erythrocytes in fluid-turbulent bioreactors. We investigated the effects of shear-stress on differentiating CD49d+CD235a+ primary human erythroblasts (EBL) at ...
Giulia Iacono, Asena Abay, Joan S. Gallego Murillo, Francesca Aglialoro, Nurcan Yagci, Eszter Varga, Tieme Bijlsma, Justine Sohler, Kerly Fu, Julie A. Reisz, Amy Argabright, Angelo D’Alessandro, Arthur F. Svendsen, Marieke von Lindern, Emile van den Akker   +14 more
doaj   +1 more source

Hemoglobin switching in mice carrying the Klf1^Nan variant

Haematologica, 2020
Haploinsufficiency for transcription factor KLF1 causes a variety of human erythroid phenotypes, such as the In(Lu) blood type, increased HbA2 levels, and hereditary persistence of fetal hemoglobin. Severe dominant congenital dyserythropoietic anemia IV
Anne Korporaal, Nynke Gillemans, Steven Heshusius, Ileana Cantú, Emile van den Akker, Thamar B. van Dijk, Marieke von Lindern, Sjaak Philipsen   +7 more
doaj   +1 more source