Results 11 to 20 of about 187,916 (412)
Trends in Immunology, 2021 Hematopoiesis is a dynamic process in which stem and progenitor cells give rise to the ~1013 blood and immune cells distributed throughout the human body. We argue that a quantitative description of hematopoiesis can help consolidate existing data, identify knowledge gaps, and generate new hypotheses.
Jason Cosgrove +3 more
openaire +5 more sources
A Plethora of Functions Condensed into Tiny Phospholipids: The Story of PI4P and PI(4,5)P2
Cells, 2023 Phosphoinositides (PIs) are small, phosphorylated lipids that serve many functions in the cell. They regulate endo- and exocytosis, vesicular trafficking, actin reorganization, and cell mobility, and they act as signaling molecules. The most abundant PIs
Ana Bura +4 more
doaj +1 more source
BMC Bioinformatics, 2022 Background Although both copy number variations (CNVs) and single nucleotide variations (SNVs) detected by single-cell RNA sequencing (scRNA-seq) are used to study intratumor heterogeneity and detect clonal groups, a software that integrates these two ...
Jeerthi Kannan +4 more
doaj +1 more source
TET2-mutant clonal hematopoiesis and risk of gout
Blood, 2022 Gout is a common inflammatory arthritis defined by NLRP3 inflammasome– and IL1β-dependent innate immune responses to monosodium urate (MSU) crystals. Agrawal et al identified clonal hematopoiesis of indeterminate potential (CHIP) as a risk factor for ...
M. Agrawal +22 more
semanticscholar +1 more source
Communications Biology, 2023 TAZ::CAMTA1 is a fusion protein found in over 90% of Epithelioid Hemangioendothelioma (EHE), a rare vascular sarcoma with an unpredictable disease course. To date, how TAZ::CAMTA1 initiates tumour formation remains unexplained.
Emily Neil +4 more
doaj +1 more source
Nature Communications, 2022 Age-related changes to the genome-wide DNA methylation (DNAm) pattern observed in blood are well-documented. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by the age-related acquisition and expansion of leukemogenic mutations in ...
M. Uddin +31 more
semanticscholar +1 more source
Antioxidants, 2023 Adult T cell leukemia/lymphoma (ATLL) is an aggressive T-cell malignancy that develops in some elderly human T-cell leukemia virus (HTVL-1) carriers.
Piyanard Boonnate +2 more
doaj +1 more source
B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis
Nature Immunology, 2022 Autonomic nerves control organ function through the sympathetic and parasympathetic branches, which have opposite effects. In the bone marrow, sympathetic (adrenergic) nerves promote hematopoiesis; however, how parasympathetic (cholinergic) signals ...
Maximilian J. Schloss +27 more
semanticscholar +1 more source
Iron-loaded deferiprone can support full hemoglobinization of cultured red blood cells
Scientific Reports, 2023 Iron, supplemented as iron-loaded transferrin (holotransferrin), is an essential nutrient in mammalian cell cultures, particularly for erythroid cultures.
Joan Sebastián Gallego-Murillo +5 more
doaj +1 more source
Cancer therapy shapes the fitness landscape of clonal hematopoiesis
Nature Genetics, 2020 Acquired mutations are pervasive across normal tissues. However, understanding of the processes that drive transformation of certain clones to cancer is limited.
K. Bolton +63 more
semanticscholar +1 more source