Results 21 to 30 of about 90,270 (303)

MEIS1 regulates early erythroid and megakaryocytic cell fate

Haematologica, 2014
MEIS1 is a transcription factor expressed in hematopoietic stem and progenitor cells and in mature megakaryocytes. This biphasic expression of MEIS1 suggests that the function of MEIS1 in stem cells is distinct from its function in lineage committed ...
Sabrina Zeddies, Sjoert B. G. Jansen, Franca di Summa, Dirk Geerts, Jaap J. Zwaginga, C. Ellen van der Schoot, Marieke von Lindern, Daphne C. Thijssen-Timmer   +7 more
doaj   +1 more source

RNA-Binding Protein Expression Alters Upon Differentiation of Human B Cells and T Cells

Frontiers in Immunology, 2021
B cells and T cells are key players in the defence against infections and malignancies. To exert their function, B cells and T cells differentiate into effector and memory cells. Tight regulation of these differentiation processes is key to prevent their
Nordin D. Zandhuis, Nordin D. Zandhuis, Benoit P. Nicolet, Benoit P. Nicolet, Monika C. Wolkers, Monika C. Wolkers   +5 more
doaj   +1 more source

The Shape Shifting Story of Reticulocyte Maturation

Frontiers in Physiology, 2018
The final steps of erythropoiesis involve unique cellular processes including enucleation and reorganization of membrane proteins and the cytoskeleton to produce biconcave erythrocytes. Surprisingly this process is still poorly understood.
Elina Ovchynnikova, Elina Ovchynnikova, Francesca Aglialoro, Francesca Aglialoro, Marieke von Lindern, Marieke von Lindern, Emile van den Akker, Emile van den Akker   +7 more
doaj   +1 more source

Large-scale in vitro production of red blood cells from human peripheral blood mononuclear cells

Blood Advances, 2019
: Transfusion of donor-derived red blood cells (RBC) is the most common form of cellular therapy. Donor availability and the potential risk of alloimmunization and other transfusion-related complications may, however, limit the availability of ...
Steven Heshusius, Esther Heideveld, Patrick Burger, Marijke Thiel-Valkhof, Erica Sellink, Eszter Varga, Elina Ovchynnikova, Anna Visser, Joost H.A. Martens, Marieke von Lindern, Emile van den Akker   +10 more
doaj   +1 more source

Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8+ T Cells in the Lungs

Frontiers in Immunology, 2019
Tissue-resident memory CD8+ T (TRM) cells that develop in the epithelia at portals of pathogen entry are important for improved protection against re-infection.
Felix M. Behr, Felix M. Behr, Natasja A. M. Kragten, Thomas H. Wesselink, Benjamin Nota, Rene A. W. van Lier, Derk Amsen, Regina Stark, Pleun Hombrink, Klaas P. J. M. van Gisbergen, Klaas P. J. M. van Gisbergen   +10 more
doaj   +1 more source

A novel Boolean network inference strategy to model early hematopoiesis aging

Computational and Structural Biotechnology Journal, 2023
Hematopoietic stem cell (HSC) aging is a multifactorial event leading to changes in HSC properties and functions, which are intrinsically coordinated and affect the early hematopoiesis.
Léonard Hérault, Mathilde Poplineau, Estelle Duprez, Élisabeth Remy   +3 more
doaj   +1 more source

Nestin-GFP transgene labels immunoprivileged bone marrow mesenchymal stem cells in the model of ectopic foci formation

Frontiers in Cell and Developmental Biology, 2022
Immune privileges are demonstrated for different types of quiescent stem cells of adult mammalian organisms. Mesenchymal stem cells (MSCs) are believed to have immune privileges; however, an accurate experimental confirmation hasn’t been presented. Here,
Dmitriy Karpenko, Nikolay Kapranov, Aleksei Bigildeev   +2 more
doaj   +1 more source

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

LSD1/KDM1A and GFI1B repress endothelial fate and induce hematopoietic fate in induced pluripotent stem cell-derived hemogenic endotheliums

Haematologica
Differentiation of induced pluripotent stem cells (iPSCs) into hematopoietic lineages offers great therapeutic potential. During embryogenesis, hemogenic endothelium (HE) gives rise to hematopoietic stem and progenitor cells through the endothelial-to ...
Huan Zhang, Marten Hansen, Franca di Summa, Marieke von Lindern, Nynke Gillemans, Wilfred F.J. van IJcken, Arthur Flohr Svendsen, Sjaak Philipsen, Bert van der Reijden, Eszter Varga, Emile van den Akker   +10 more
doaj   +1 more source

E-Cadherin Expression Distinguishes Mouse from Human Hematopoiesis in the Basophil and Erythroid Lineages

Biomolecules, 2022
E-cadherin is a key regulator of epithelial cell–cell adhesion, the loss of which accelerates tumor growth and invasion. E-cadherin is also expressed in hematopoietic cells as well as epithelia.
Rosa A. Krimpenfort, Felix M. Behr, Marja Nieuwland, Iris de Rink, Ron Kerkhoven, Marieke von Lindern, Micha Nethe   +6 more
doaj   +1 more source