Results 21 to 30 of about 187,916 (412)

Association of clonal hematopoiesis with chronic obstructive pulmonary disease

Blood, 2021
Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related phenomenon that induces inflammation. Since CHIP is a risk factor for cardiovascular disease, Miller and colleagues investigated the association between CHIP and chronic obstructive
P. Miller, D. Qiao, J. Rojas-Quintero, M. Honigberg, A. Sperling, C. Gibson, A. Bick, A. Niroula, M. McConkey, Brittany Sandoval, Brian C Miller, Weiwei Shi, Kaushik Viswanathan, Matthew J. Leventhal, L. Werner, M. Moll, B. Cade, R. Barr, A. Correa, L. Cupples, Sina A. Gharib, D. Jain, S. Gogarten, L. Lange, Stephanie A. London, A. Manichaikul, G. O'Connor, E. Oelsner, S. Redline, S. Rich, J. Rotter, V. Ramachandran, B. Yu, L. Sholl, D. Neuberg, S. Jaiswal, B. Levy, C. Owen, P. Natarajan, E. Silverman, Peter van Galen, Y. Tesfaigzi, M. Cho, B. Ebert   +43 more
semanticscholar   +1 more source

Regulation of Hematopoiesis [PDF]

Pediatric Research, 1990
David G. Nathan
openaire   +4 more sources

The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis. [PDF]

, 2018
Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs).
Li, Shengwen Calvin, Li, Zhongjun, Ran, Qian, Wu, Jiang, Xiang, Yang, Zhang, Weiwei, Zhong, Jiang F   +6 more
core   +2 more sources

Age-related clonal hematopoiesis associated with adverse outcomes.

New England Journal of Medicine, 2014
BACKGROUND The incidence of hematologic cancers increases with age. These cancers are associated with recurrent somatic mutations in specific genes. We hypothesized that such mutations would be detectable in the blood of some persons who are not known to
S. Jaiswal, P. Fontanillas, J. Flannick, A. Manning, Peter V. Grauman, B. Mar, R. C. Lindsley, C. Mermel, N. Burtt, A. Chavez, J. Higgins, V. Moltchanov, F. Kuo, Michael J. Kluk, B. Henderson, L. Kinnunen, H. Koistinen, C. Ladenvall, G. Getz, A. Correa, B. Banahan, S. Gabriel, S. Kathiresan, H. Stringham, M. McCarthy, M. Boehnke, J. Tuomilehto, C. Haiman, L. Groop, G. Atzmon, James G. Wilson, D. Neuberg, D. Altshuler, B. Ebert   +33 more
semanticscholar   +1 more source

Generation of human erythroblast-derived iPSC line using episomal reprogramming system

Stem Cell Research, 2017
Peripheral blood mononuclear cells were isolated and cultured to a pure pro-EBL population and reprogrammed using episomal plasmids. The pluripotency of transgene-free induced pluripotent stem cell (iPSC) line was verified by the expression of ...
Eszter Varga, Marten Hansen, Tatjana Wüst, Marieke von Lindern, Emile van den Akker   +4 more
doaj   +1 more source

Studies on reticuloendothelial system and hemaotpoiesis. I. Studies of extramedullary hematopoiesis [PDF]

, 1965
The author studied the hematopoietic disturbances of rabbit induced by saponin injection and drew the following conclusions: 1) By saponin injection, the structure of bone marrow is disintegrated and hematopoietic cells are released into the circulating ...
Matsuoka, Kenichi
core   +1 more source

Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation. [PDF]

, 2017
Hemogenic endothelium (HE) undergoes endothelial-to-hematopoietic transition (EHT) to generate blood, a process that requires progressive down-regulation of endothelial genes and induction of hematopoietic ones.
Beuder, Steven, Chou, Tsui-Fen, Clarke, Don, Iacovino, Michelina, Kee, Dustin, Kyba, Michael, Luzzi, Anna, Madrenas, Joaquín, Osawa, Mitsujiro, Rux, Danielle, Sanghez, Valentina   +10 more
core   +8 more sources

MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation. [PDF]

, 2018
We show for the first time that, in contrast to other glutathione transferases and peroxidases, deletion of microsomal glutathione transferase 1 (MGST1) in mice is embryonic lethal.
Abe, Hiroshi, Bräutigam, Lars, Dreij, Kristian, Holmgren, Arne, Johansson, Katarina, Kelner, Michael J, Morgenstern, Ralf, Spahiu, Linda, Tew, Kenneth D, Townsend, Danyelle M, Zhang, Jie   +10 more
core   +3 more sources

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence.

New England Journal of Medicine, 2014
BACKGROUND Cancers arise from multiple acquired mutations, which presumably occur over many years. Early stages in cancer development might be present years before cancers become clinically apparent. METHODS We analyzed data from whole-exome sequencing
G. Genovese, A. Kähler, R. Handsaker, J. Lindberg, Samuel A. Rose, S. Bakhoum, K. Chambert, E. Mick, B. Neale, M. Fromer, S. Purcell, Oscar Svantesson, M. Landén, M. Höglund, S. Lehmann, S. Gabriel, J. Moran, E. Lander, P. Sullivan, P. Sklar, H. Grönberg, C. Hultman, S. Mccarroll   +22 more
semanticscholar   +1 more source

Inherited Causes of Clonal Hematopoiesis in 97,691 TOPMed Whole Genomes

Nature, 2020
Age is the dominant risk factor for most chronic human diseases, but the mechanisms through which ageing confers this risk are largely unknown 1 .
A. Bick, J. Weinstock, Satish K. Nandakumar, Satish K. Nandakumar, C. Fulco, C. Fulco, Erik L. Bao, Erik L. Bao, S. Zekavat, S. Zekavat, M. Szeto, Xiaotian Liao, Xiaotian Liao, Matthew J. Leventhal, J. Nasser, K. Chang, C. Laurie, B. Burugula, C. Gibson, A. E. Lin, M. Taub, F. Aguet, K. Ardlie, B. Mitchell, B. Mitchell, Kathleen C. Barnes, Kathleen C. Barnes, A. Moscati, M. Fornage, S. Redline, S. Redline, S. Redline, B. Psaty, E. Silverman, E. Silverman, Scott T. Weiss, S. Weiss, Nicholette D. Palmer, R. Vasan, E. Burchard, S. Kardia, Jiang He, R. C. Kaplan, R. C. Kaplan, N. Smith, N. Smith, D. Arnett, D. Schwartz, A. Correa, M. Andrade, Xiuqing Guo, B. Konkle, B. Custer, J. Peralta, H. Gui, D. Meyers, S. McGarvey, I. Chen, M. B. Shoemaker, P. Peyser, J. Broome, S. Gogarten, F. Wang, Q. Wong, M. Montasser, M. Daya, E. Kenny, K. North, L. Launer, B. Cade, B. Cade, J. Bis, M. Cho, M. Cho, J. Lasky-Su, J. Lasky-Su, D. Bowden, L. Cupples, Angel C. Y. Mak, L. Becker, Jennifer A. Smith, T. Kelly, S. Aslibekyan, S. Heckbert, S. Heckbert, H. Tiwari, Ivana V. Yang, J. Heit, S. Lubitz, S. Lubitz, J. Johnsen, J. Curran, S. Wenzel, D. Weeks, D. Rao, D. Darbar, Jee-Young Moon, R. Tracy, Erin Buth, N. Rafaels, R. Loos, P. Durda, Yongmei Liu, L. Hou, Jiwon Lee, P. Kachroo, P. Kachroo, B. Freedman, D. Levy, L. Bielak, J. Hixson, J. Floyd, E. Whitsel, P. Ellinor, P. Ellinor, M. Irvin, T. Fingerlin, L. Raffield, Sebastian M. Armasu, Marsha M. Wheeler, E. Sabino, J. Blangero, L. Williams, B. Levy, B. Levy, W. Sheu, D. Roden, E. Boerwinkle, E. Boerwinkle, J. Manson, J. Manson, R. Mathias, Pinkal M. Desai, K. Taylor, Andrew D. Johnson, P. Auer, C. Kooperberg, C. Laurie, T. Blackwell, A. Smith, Hongyu Zhao, E. Lange, L. Lange, S. Rich, J. Rotter, James G. Wilson, James G. Wilson, P. Scheet, J. Kitzman, E. Lander, E. Lander, E. Lander, J. Engreitz, J. Engreitz, B. Ebert, A. Reiner, A. Reiner, S. Jaiswal, G. Abecasis, G. Abecasis, V. Sankaran, V. Sankaran, S. Kathiresan, P. Natarajan, P. Natarajan   +164 more
semanticscholar   +1 more source