Results 21 to 30 of about 134,478 (313)

Recognizing early MRI signs (or their absence) is crucial in diagnosing metachromatic leukodystrophy

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1999-2009, December 2022., 2022
Abstract Objectives Metachromatic leukodystrophy (MLD) has characteristic white matter (WM) changes on brain MRI, which often trigger biochemical and genetic confirmation of the diagnosis. In early or pre‐symptomatic disease stages, these typical MRI changes might be absent, hampering early diagnosis.
Daphne H. Schoenmakers, Shanice Beerepoot, Ingeborg Krägeloh‐Mann, Saskia Elgün, Benjamin Bender, Marjo S. van der Knaap, Nicole I. Wolf, Samuel Groeschel   +7 more
wiley   +1 more source

p53 mediates failure of human definitive hematopoiesis in dyskeratosis congenita [PDF]

, 2017
Summary: Dyskeratosis congenita (DC) is a bone marrow failure syndrome associated with telomere dysfunction. The progression and molecular determinants of hematopoietic failure in DC remain poorly understood.
Batista, Luis Francisco Zirnberger, Brenner, Kirsten Ann, Dege, Carissa, Fok, Wilson Chun, Niero, Evandro Luis de Oliveira, Sturgeon, Christopher Michael   +5 more
core   +3 more sources

Optimal experimental design for mathematical models of haematopoiesis. [PDF]

, 2021
The haematopoietic system has a highly regulated and complex structure in which cells are organized to successfully create and maintain new blood cells.
Iniguez, Abdon, Jena, Nilamani, Lander, Arthur D, Liu, Zhong-Ying, Lomeli, Luis Martinez, Lowengrub, John S, Minin, Vladimir N, Shahbaba, Babak, Tata, Prasanthi, Van Etten, Richard   +9 more
core   +1 more source

Fludarabine as a cost-effective adjuvant to enhance engraftment of human normal and malignant hematopoiesis in immunodeficient mice [PDF]

, 2018
There is still an unmet need for xenotransplantation models that efficiently recapitulate normal and malignant human hematopoiesis. Indeed, there are a number of strategies to generate humanized mice and specific protocols, including techniques to ...
A Rambaldi, A Terenzi, AM Carroll, AM Carroll, BS Andersson, CR Giver, D Niederwieser, DA Frank, DE Mosier, E McCormack, F Aversa, IF Khouri, K Tajima, L Luznik, L Weiss, M Furukawa, NC Kirkiles-Smith, S Goyama   +17 more
core   +1 more source

Comprehensive network modeling from single cell RNA sequencing of human and mouse reveals well conserved transcription regulation of hematopoiesis

BMC Genomics, 2020
Background Presently, there is no comprehensive analysis of the transcription regulation network in hematopoiesis. Comparison of networks arising from gene co-expression across species can facilitate an understanding of the conservation of functional ...
Shouguo Gao, Zhijie Wu, Xingmin Feng, Sachiko Kajigaya, Xujing Wang, Neal S. Young   +5 more
doaj   +1 more source

Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points

Epigenetics & Chromatin, 2018
Background Enhancers and promoters are cis-acting regulatory elements associated with lineage-specific gene expression. Previous studies showed that different categories of active regulatory elements are in regions of open chromatin, and each category is
Elisabeth F. Heuston, Cheryl A. Keller, Jens Lichtenberg, Belinda Giardine, Stacie M. Anderson, NIH Intramural Sequencing Center, Ross C. Hardison, David M. Bodine   +7 more
doaj   +1 more source

CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages

Nature Communications, 2018
Dendritic cells (DC) are important regulators of both innate and adaptive immunity, but how the DC pool is homeostatically maintained in vivo is unclear.
Gulce Itir Percin, Jiri Eitler, Andrea Kranz, Jun Fu, Jeffrey W. Pollard, Ronald Naumann, Claudia Waskow   +6 more
doaj   +1 more source

The Potential of Tissue-Resident Memory T Cells for Adoptive Immunotherapy against Cancer

Cells, 2021
Tissue-resident memory T cells (TRM) comprise an important memory T cell subset that mediates local protection upon pathogen re-encounter. TRM populations preferentially localize at entry sites of pathogens, including epithelia of the skin, lungs and ...
Ammarina Beumer-Chuwonpad, Renske L. R. E. Taggenbrock, T. An Ngo, Klaas P. J. M. van Gisbergen   +3 more
doaj   +1 more source

Multi-Agent Systems and Blood Cell Formation [PDF]

Multi-Agent Systems - Modeling, Interactions, Simulations and Case Studies, InTech (Ed.) (2011) 502, 2013
The objective of this chapter is to give an insight of the mathematical modellng of hematopoiesis using multi-agent systems. Several questions may arise then: what is hematopoiesis and why is it interesting to study this problem from a mathematical point of view? Has the multi-agent system approach been the only attempt done until now?
arxiv   +1 more source

Master regulators as order parameters of gene expression states [PDF]

Phys. Rev. E 103, 012409 (2021), 2020
Cell type-specific gene expression patterns are represented as memory states of a Hopfield neural network model. It is shown that order parameters of this model can be interpreted as concentrations of master transcription regulators that form concurrent positive feedback loops with a large number of downstream regulated genes.
arxiv   +1 more source