Results 21 to 30 of about 157,726 (359)

Single-cell RNA-seq reveals a concomitant delay in differentiation and cell cycle of aged hematopoietic stem cells

BMC Biology, 2021
Background Hematopoietic stem cells (HSCs) are the guarantor of the proper functioning of hematopoiesis due to their incredible diversity of potential.
Léonard Hérault, Mathilde Poplineau, Adrien Mazuel, Nadine Platet, Élisabeth Remy, Estelle Duprez   +5 more
doaj   +1 more source

Comprehensive network modeling from single cell RNA sequencing of human and mouse reveals well conserved transcription regulation of hematopoiesis

BMC Genomics, 2020
Background Presently, there is no comprehensive analysis of the transcription regulation network in hematopoiesis. Comparison of networks arising from gene co-expression across species can facilitate an understanding of the conservation of functional ...
Shouguo Gao, Zhijie Wu, Xingmin Feng, Sachiko Kajigaya, Xujing Wang, Neal S. Young   +5 more
doaj   +1 more source

Modelling hematopoiesis mediated by growth factors with applications to periodic hematological diseases [PDF]

, 2006
Hematopoiesis is a complex biological process that leads to the production and regulation of blood cells. It is based upon differentiation of stem cells under the action of growth factors.
Adimy, Mostafa, Crauste, Fabien, Ruan, Shigui   +2 more
core   +5 more sources

CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages

Nature Communications, 2018
Dendritic cells (DC) are important regulators of both innate and adaptive immunity, but how the DC pool is homeostatically maintained in vivo is unclear.
Gulce Itir Percin, Jiri Eitler, Andrea Kranz, Jun Fu, Jeffrey W. Pollard, Ronald Naumann, Claudia Waskow   +6 more
doaj   +1 more source

The Potential of Tissue-Resident Memory T Cells for Adoptive Immunotherapy against Cancer

Cells, 2021
Tissue-resident memory T cells (TRM) comprise an important memory T cell subset that mediates local protection upon pathogen re-encounter. TRM populations preferentially localize at entry sites of pathogens, including epithelia of the skin, lungs and ...
Ammarina Beumer-Chuwonpad, Renske L. R. E. Taggenbrock, T. An Ngo, Klaas P. J. M. van Gisbergen   +3 more
doaj   +1 more source

Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply. [PDF]

, 2018
Lipoprotein lipase (LPL) mediates hydrolysis of triglycerides (TGs) to supply free fatty acids (FFAs) to tissues. Here, we show that LPL activity is also required for hematopoietic stem progenitor cell (HSPC) maintenance.
Han, Tianxu, Kim, Jungsu, Klemke, Richard L, Liu, Chao, Miller, Yury I, Rana, Tariq M, Remaley, Alan T, Stachura, David L, Traver, David, Vaisman, Boris L, Wang, Huawei   +10 more
core   +2 more sources

CD82 expression marks the endothelium to hematopoietic transition at the onset of blood specification in human

iScience, 2023
Summary: During embryonic development, all blood progenitors are initially generated from endothelial cells that acquire a hemogenic potential. Blood progenitors emerge through an endothelial-to-hematopoietic transition regulated by the transcription ...
Sara Menegatti, Bethany Potts, Roberto Paredes, Eva Garcia-Alegria, Syed Murtuza Baker, Valerie Kouskoff   +5 more
doaj   +1 more source

Identification of stromal cells in spleen which support myelopoiesis [PDF]

, 2019
Stromal cells in spleen organize tissue into red pulp, white pulp and marginal zone, and also interact with hematopoietic cells to regulate immune responses.
Lim, Hong, O'Neill, Helen C
core   +2 more sources

Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

OncoImmunology, 2019
Non-small cell lung cancer (NSCLC) is the second most prevalent type of cancer. With the current treatment regimens, the mortality rate remains high. Therefore, better therapeutic approaches are necessary.
Rosa De Groot, Marleen M. Van Loenen, Aurélie Guislain, Benoît P. Nicolet, Julian J. Freen-Van Heeren, Onno J.H.M. Verhagen, Michel M. Van Den Heuvel, Jeroen De Jong, Patrick Burger, C.Ellen Van Der Schoot, Robbert M. Spaapen, Derk Amsen, John B. A. G. Haanen, Kim Monkhorst, Koen J. Hartemink, Monika C. Wolkers   +15 more
doaj   +1 more source

Long Non-Coding RNAs: New Players in Hematopoiesis and Leukemia [PDF]

, 2015
Long non-coding RNAs (lncRNAs) are important regulators of gene expression that influence almost every step in the life cycle of genes, from transcription to mRNA splicing, RNA decay, and translation.
Ballarino, Monica, Fatica, Alessandro, Morlando, Mariangela   +2 more
core   +2 more sources