Results 31 to 40 of about 159,775 (264)

Long Non-Coding RNAs: New Players in Hematopoiesis and Leukemia [PDF]

, 2015
Long non-coding RNAs (lncRNAs) are important regulators of gene expression that influence almost every step in the life cycle of genes, from transcription to mRNA splicing, RNA decay, and translation.
Ballarino, Monica, Fatica, Alessandro, Morlando, Mariangela   +2 more
core   +2 more sources

Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

OncoImmunology, 2019
Non-small cell lung cancer (NSCLC) is the second most prevalent type of cancer. With the current treatment regimens, the mortality rate remains high. Therefore, better therapeutic approaches are necessary.
Rosa De Groot, Marleen M. Van Loenen, Aurélie Guislain, Benoît P. Nicolet, Julian J. Freen-Van Heeren, Onno J.H.M. Verhagen, Michel M. Van Den Heuvel, Jeroen De Jong, Patrick Burger, C.Ellen Van Der Schoot, Robbert M. Spaapen, Derk Amsen, John B. A. G. Haanen, Kim Monkhorst, Koen J. Hartemink, Monika C. Wolkers   +15 more
doaj   +1 more source

Bone Marrow Harbors a Unique Population of Dendritic Cells with the Potential to Boost Neutrophil Formation upon Exposure to Fungal Antigen

Cells, 2021
Apart from controlling hematopoiesis, the bone marrow (BM) also serves as a secondary lymphoid organ, as it can induce naïve T cell priming by resident dendritic cells (DC).
Marieke Goedhart, Edith Slot, Maria F. Pascutti, Sulima Geerman, Timo Rademakers, Benjamin Nota, Stephan Huveneers, Jaap D. van Buul, Katherine C. MacNamara, Carlijn Voermans, Martijn A. Nolte   +10 more
doaj   +1 more source

CREB is a critical regulator of normal hematopoiesis and leukemogenesis [PDF]

, 2008
The cAMP-responsive element binding protein (CREB) is a 43-kDa nuclear transcription factor that regulates cell growth, memory, and glucose homeostasis. We showed previously that CREB is amplified in myeloid leukemia blasts and expressed at higher levels
Akashi, Akashi, Bai, Bottazzi, Bruserud, Cheng, Christensen, Conkright, Crans-Vargas, Deepa B. Shankar, Dejah R. Judelson, Desdouets, Deshpande, Elliot M. Landaw, Fried, Fu, Hestdal, Impey, Ingrid Schmid, Jamieson, Jenny Chang, Jerry C. Cheng, Kathleen M. Sakamoto, Kentaro Kinjo, Kim, Kinjo, Kohn, Kondo, Koschmieder, Koya, Krishan, Kwon, Lee, Mayr, Mendoza, Miyoshi, Montminy, Ninomiya, Noriyuki Kasahara, Passegué, Ravi Bhatia, Rehemtulla, Renata Stripecke, Scherr, Shah, Shankar, Shankar, Shaywitz, Stripecke, Traver, Tuschl, Van Etten, Ventura, Winston S. Wu, Wong, Yuan   +55 more
core   +3 more sources

Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply. [PDF]

, 2018
Lipoprotein lipase (LPL) mediates hydrolysis of triglycerides (TGs) to supply free fatty acids (FFAs) to tissues. Here, we show that LPL activity is also required for hematopoietic stem progenitor cell (HSPC) maintenance.
Han, Tianxu, Kim, Jungsu, Klemke, Richard L, Liu, Chao, Miller, Yury I, Rana, Tariq M, Remaley, Alan T, Stachura, David L, Traver, David, Vaisman, Boris L, Wang, Huawei   +10 more
core   +2 more sources

MEIS1 regulates early erythroid and megakaryocytic cell fate

Haematologica, 2014
MEIS1 is a transcription factor expressed in hematopoietic stem and progenitor cells and in mature megakaryocytes. This biphasic expression of MEIS1 suggests that the function of MEIS1 in stem cells is distinct from its function in lineage committed ...
Sabrina Zeddies, Sjoert B. G. Jansen, Franca di Summa, Dirk Geerts, Jaap J. Zwaginga, C. Ellen van der Schoot, Marieke von Lindern, Daphne C. Thijssen-Timmer   +7 more
doaj   +1 more source

RNA-Binding Protein Expression Alters Upon Differentiation of Human B Cells and T Cells

Frontiers in Immunology, 2021
B cells and T cells are key players in the defence against infections and malignancies. To exert their function, B cells and T cells differentiate into effector and memory cells. Tight regulation of these differentiation processes is key to prevent their
Nordin D. Zandhuis, Nordin D. Zandhuis, Benoit P. Nicolet, Benoit P. Nicolet, Monika C. Wolkers, Monika C. Wolkers   +5 more
doaj   +1 more source

Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis [PDF]

, 2011
The Hox family are master transcriptional regulators of developmental processes, including hematopoiesis. The Hox regulators, caudal homeobox factors (Cdx1-4), and Meis1, along with several individual Hox proteins, are implicated in stem cell expansion ...
Alexander Thompson, Belotti D, Buske C, Deschamps J, Edwina Dobbin, Glenda J. Dickson, Helen Wheadon, Joanne M. Ramsey, Lawrence HJ, Pamela M. Corrigan, Robin W. Freeburn   +10 more
core   +1 more source

The Shape Shifting Story of Reticulocyte Maturation

Frontiers in Physiology, 2018
The final steps of erythropoiesis involve unique cellular processes including enucleation and reorganization of membrane proteins and the cytoskeleton to produce biconcave erythrocytes. Surprisingly this process is still poorly understood.
Elina Ovchynnikova, Elina Ovchynnikova, Francesca Aglialoro, Francesca Aglialoro, Marieke von Lindern, Marieke von Lindern, Emile van den Akker, Emile van den Akker   +7 more
doaj   +1 more source

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis [PDF]

, 2014
Although hematopoietic precursor activity can be generated in vitro from human embryonic stem cells, there is no solid evidence for the appearance of multipotent, self-renewing and transplantable hematopoietic stem cells.
De Bleser, Dominique, De Mulder, Katrien, Kerre, Tessa, Lambrecht, Bart, Leclercq, Georges, Menten, Björn, Philippé, Jan, Taghon, Tom, Van Caeneghem, Yasmine, Van Roy, Nadine, Vandekerckhove, Bart, Vanhee, Stijn, Velghe, Imke, Verstichel, Greet   +13 more
core   +3 more sources