Role of vitamin A/retinoic acid in regulation of embryonic and adult hematopoiesis [PDF]
, 2017 Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being ...
Adamo +23 more
core +4 more sources
OncoImmunology, 2019 Non-small cell lung cancer (NSCLC) is the second most prevalent type of cancer. With the current treatment regimens, the mortality rate remains high. Therefore, better therapeutic approaches are necessary.
Rosa De Groot +15 more
doaj +1 more source
Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis [PDF]
, 2011 The Hox family are master transcriptional regulators of developmental processes, including hematopoiesis. The Hox regulators, caudal homeobox factors (Cdx1-4), and Meis1, along with several individual Hox proteins, are implicated in stem cell expansion ...
Alexander Thompson +10 more
core +1 more source
Cells, 2021 Apart from controlling hematopoiesis, the bone marrow (BM) also serves as a secondary lymphoid organ, as it can induce naïve T cell priming by resident dendritic cells (DC).
Marieke Goedhart +10 more
doaj +1 more source
Identification of stromal cells in spleen which support myelopoiesis [PDF]
, 2019 Stromal cells in spleen organize tissue into red pulp, white pulp and marginal zone, and also interact with hematopoietic cells to regulate immune responses.
Lim, Hong, O'Neill, Helen C
core +2 more sources
Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation. [PDF]
, 2017 Hemogenic endothelium (HE) undergoes endothelial-to-hematopoietic transition (EHT) to generate blood, a process that requires progressive down-regulation of endothelial genes and induction of hematopoietic ones.
Beuder, Steven +10 more
core +8 more sources
A mathematical study of the hematopoiesis process with applications to chronic myelogenous leukemia [PDF]
SIAM Journal on Applied Mathematics 65, 4 (2005) 1328-1352, 2009 This paper is devoted to the analysis of a mathematical model of blood cells production in the bone marrow (hematopoiesis). The model is a system of two age-structured partial differential equations. Integrating these equations over the age, we obtain a system of two nonlinear differential equations with distributed time delay corresponding to the cell
arxiv +1 more source
MEIS1 regulates early erythroid and megakaryocytic cell fate
Haematologica, 2014 MEIS1 is a transcription factor expressed in hematopoietic stem and progenitor cells and in mature megakaryocytes. This biphasic expression of MEIS1 suggests that the function of MEIS1 in stem cells is distinct from its function in lineage committed ...
Sabrina Zeddies +7 more
doaj +1 more source
RNA-Binding Protein Expression Alters Upon Differentiation of Human B Cells and T Cells
Frontiers in Immunology, 2021 B cells and T cells are key players in the defence against infections and malignancies. To exert their function, B cells and T cells differentiate into effector and memory cells. Tight regulation of these differentiation processes is key to prevent their
Nordin D. Zandhuis +5 more
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LYVE1 Marks the Divergence of Yolk Sac Definitive Hemogenic Endothelium from the Primitive Erythroid Lineage. [PDF]
, 2016 The contribution of the different waves and sites of developmental hematopoiesis to fetal and adult blood production remains unclear. Here, we identify lymphatic vessel endothelial hyaluronan receptor-1 (LYVE1) as a marker of yolk sac (YS ...
Ghorbanian, Yasamine +7 more
core +1 more source