Results 41 to 50 of about 154,498 (360)

Long Non-Coding RNAs: New Players in Hematopoiesis and Leukemia [PDF]

, 2015
Long non-coding RNAs (lncRNAs) are important regulators of gene expression that influence almost every step in the life cycle of genes, from transcription to mRNA splicing, RNA decay, and translation.
Ballarino, Monica, Fatica, Alessandro, Morlando, Mariangela   +2 more
core   +2 more sources

Aging and Hematopoiesis

Clinics in Geriatric Medicine, 2019
In hematopoiesis, mature blood cells, granulocytes, erythrocytes, and megakaryocytes originate from hematopoietic stem cells. With age, changes in hematopoiesis may have clinical consequences: defective immune responses, cytopenias (most commonly anemia and lymphopenia), hematological malignancy, and effects mediated by hematopoietic cells in other ...
Neal S. Young, Emma M. Groarke
openaire   +3 more sources

Clonal hematopoiesis [PDF]

Seminars in Hematology, 2017
Cancer results from multistep pathogenesis, yet the pre-malignant states that precede the development of many hematologic malignancies have been difficult to identify. Recent genomic studies of blood DNA from tens of thousands of people have revealed the presence of remarkably common, age-associated somatic mutations in genes associated with ...
Max, Jan, Benjamin L, Ebert, Siddhartha, Jaiswal   +2 more
openaire   +2 more sources

Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8+ T Cells in the Lungs

Frontiers in Immunology, 2019
Tissue-resident memory CD8+ T (TRM) cells that develop in the epithelia at portals of pathogen entry are important for improved protection against re-infection.
Felix M. Behr, Felix M. Behr, Natasja A. M. Kragten, Thomas H. Wesselink, Benjamin Nota, Rene A. W. van Lier, Derk Amsen, Regina Stark, Pleun Hombrink, Klaas P. J. M. van Gisbergen, Klaas P. J. M. van Gisbergen   +10 more
doaj   +1 more source

CREB is a critical regulator of normal hematopoiesis and leukemogenesis [PDF]

, 2008
The cAMP-responsive element binding protein (CREB) is a 43-kDa nuclear transcription factor that regulates cell growth, memory, and glucose homeostasis. We showed previously that CREB is amplified in myeloid leukemia blasts and expressed at higher levels
Akashi, Akashi, Bai, Bottazzi, Bruserud, Cheng, Christensen, Conkright, Crans-Vargas, Deepa B. Shankar, Dejah R. Judelson, Desdouets, Deshpande, Elliot M. Landaw, Fried, Fu, Hestdal, Impey, Ingrid Schmid, Jamieson, Jenny Chang, Jerry C. Cheng, Kathleen M. Sakamoto, Kentaro Kinjo, Kim, Kinjo, Kohn, Kondo, Koschmieder, Koya, Krishan, Kwon, Lee, Mayr, Mendoza, Miyoshi, Montminy, Ninomiya, Noriyuki Kasahara, Passegué, Ravi Bhatia, Rehemtulla, Renata Stripecke, Scherr, Shah, Shankar, Shankar, Shaywitz, Stripecke, Traver, Tuschl, Van Etten, Ventura, Winston S. Wu, Wong, Yuan   +55 more
core   +3 more sources

A novel Boolean network inference strategy to model early hematopoiesis aging

Computational and Structural Biotechnology Journal, 2023
Hematopoietic stem cell (HSC) aging is a multifactorial event leading to changes in HSC properties and functions, which are intrinsically coordinated and affect the early hematopoiesis.
Léonard Hérault, Mathilde Poplineau, Estelle Duprez, Élisabeth Remy   +3 more
doaj   +1 more source

FHL2 regulates hematopoietic stem cell functions under stress conditions. [PDF]

, 2015
FHL2, a member of the four and one half LIM domain protein family, is a critical transcriptional modulator. Here, we identify FHL2 as a critical regulator of hematopoietic stem cells (HSCs) that is essential for maintaining HSC self-renewal under ...
Chen, J, Fan, R, Hou, Y, Hou, Y, Jiang, Y, Li, L, Li, W, Mittal, N, Peace, D, Qian, Z, Wang, X, Wu, W, Zhu, T   +12 more
core   +2 more sources

Expression profiling of snoRNAs in normal hematopoiesis and AML [PDF]

, 2018
Key Points A subset of snoRNAs is expressed in a developmental- and lineage-specific manner during human hematopoiesis. Neither host gene expression nor alternative splicing accounted for the observed differential expression of snoRNAs in ...
Helton, Nichole, Ley, Timothy J., Link, Daniel C., Spencer, David H., Trissal, Maria, Warner, Wayne A., White, Brian S.   +6 more
core   +2 more sources

Hematopoiesis in the Elderly

Hematology, 2004
The effect of age on the hematopoietic system has always been an area of clinical interest. Alterations in lymphocyte immunophenotype and function with age have been clearly demonstrated as has a decrease in neutrophil function. However, controversy continues to surround the significance of unexplained anaemia in the elderly patient and the extent to ...
Armand Keating, Leanne Berkahn
openaire   +2 more sources

LSD1/KDM1A and GFI1B repress endothelial fate and induce hematopoietic fate in induced pluripotent stem cell-derived hemogenic endotheliums

Haematologica
Differentiation of induced pluripotent stem cells (iPSCs) into hematopoietic lineages offers great therapeutic potential. During embryogenesis, hemogenic endothelium (HE) gives rise to hematopoietic stem and progenitor cells through the endothelial-to ...
Huan Zhang, Marten Hansen, Franca di Summa, Marieke von Lindern, Nynke Gillemans, Wilfred F.J. van IJcken, Arthur Flohr Svendsen, Sjaak Philipsen, Bert van der Reijden, Eszter Varga, Emile van den Akker   +10 more
doaj   +1 more source