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Multi-Agent Systems and Blood Cell Formation [PDF]

Multi-Agent Systems - Modeling, Interactions, Simulations and Case Studies, InTech (Ed.) (2011) 502, 2013
The objective of this chapter is to give an insight of the mathematical modellng of hematopoiesis using multi-agent systems. Several questions may arise then: what is hematopoiesis and why is it interesting to study this problem from a mathematical point of view? Has the multi-agent system approach been the only attempt done until now?
arxiv   +1 more source

Master regulators as order parameters of gene expression states [PDF]

Phys. Rev. E 103, 012409 (2021), 2020
Cell type-specific gene expression patterns are represented as memory states of a Hopfield neural network model. It is shown that order parameters of this model can be interpreted as concentrations of master transcription regulators that form concurrent positive feedback loops with a large number of downstream regulated genes.
arxiv   +1 more source

Role of vitamin A/retinoic acid in regulation of embryonic and adult hematopoiesis [PDF]

, 2017
Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being ...
Adamo, Ana Cañete, Arguello, Cardoso, Dary, De Luca, Elena Cano, Gebremedhin, Gerster, Grande, Guo, Haussler, Kuwata, Lo-Coco, McLaren, Nervi, North, Ottersbach, O’Donnell, Ramón Muñoz-Chápuli, Rita Carmona, Ross, Testa, West   +23 more
core   +4 more sources

Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply. [PDF]

, 2018
Lipoprotein lipase (LPL) mediates hydrolysis of triglycerides (TGs) to supply free fatty acids (FFAs) to tissues. Here, we show that LPL activity is also required for hematopoietic stem progenitor cell (HSPC) maintenance.
Han, Tianxu, Kim, Jungsu, Klemke, Richard L, Liu, Chao, Miller, Yury I, Rana, Tariq M, Remaley, Alan T, Stachura, David L, Traver, David, Vaisman, Boris L, Wang, Huawei   +10 more
core   +2 more sources

Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation

medRxiv, 2021
PURPOSE Clonal hematopoiesis (CH) can be transmitted from a donor to a recipient during allogeneic hematopoietic cell transplantation. Exclusion of candidate donors with CH is controversial since its impact on recipient outcomes and graft alloimmune ...
C. Gibson, Haesook T. Kim, Lin Zhao, H. Murdock, B. Hambley, A. Ogata, Rafael Madero-Marroquin, Shiyu Wang, L. Green, M. Fleharty, Tyler J Dougan, Chi-An Cheng, B. Blumenstiel, C. Cibulskis, J. Tsuji, M. Duran, C. Gocke, J. Antin, S. Nikiforow, A. DeZern, Yi-Bin Chen, V. Ho, Richard J. Jones, N. Lennon, David R. Walt, J. Ritz, R. Soiffer, L. Gondek, R. C. Lindsley   +28 more
semanticscholar   +1 more source

Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

OncoImmunology, 2019
Non-small cell lung cancer (NSCLC) is the second most prevalent type of cancer. With the current treatment regimens, the mortality rate remains high. Therefore, better therapeutic approaches are necessary.
Rosa De Groot, Marleen M. Van Loenen, Aurélie Guislain, Benoît P. Nicolet, Julian J. Freen-Van Heeren, Onno J.H.M. Verhagen, Michel M. Van Den Heuvel, Jeroen De Jong, Patrick Burger, C.Ellen Van Der Schoot, Robbert M. Spaapen, Derk Amsen, John B. A. G. Haanen, Kim Monkhorst, Koen J. Hartemink, Monika C. Wolkers   +15 more
doaj   +1 more source

Bone Marrow Harbors a Unique Population of Dendritic Cells with the Potential to Boost Neutrophil Formation upon Exposure to Fungal Antigen

Cells, 2021
Apart from controlling hematopoiesis, the bone marrow (BM) also serves as a secondary lymphoid organ, as it can induce naïve T cell priming by resident dendritic cells (DC).
Marieke Goedhart, Edith Slot, Maria F. Pascutti, Sulima Geerman, Timo Rademakers, Benjamin Nota, Stephan Huveneers, Jaap D. van Buul, Katherine C. MacNamara, Carlijn Voermans, Martijn A. Nolte   +10 more
doaj   +1 more source

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes.

Blood, 2015
Recent genetic analyses of large populations have revealed that somatic mutations in hematopoietic cells leading to clonal expansion are commonly acquired during human aging.
D. Steensma, R. Bejar, S. Jaiswal, R. C. Lindsley, M. Sekeres, R. Hasserjian, B. Ebert   +6 more
semanticscholar   +1 more source

Clonal hematopoiesis in human aging and disease

Science, 2019
Cryptic signs of aging in our blood Time is not a friend to our DNA. Aging is associated with an accumulation of somatic mutations in normal dividing cells, including the hematopoietic stem cells (HSCs) that give rise to all blood cells.
S. Jaiswal, B. Ebert
semanticscholar   +1 more source

Evolution of clonal hematopoiesis

Clinical and Translational Medicine, 2023
Contains fulltext : 300034.pdf (Publisher’s version ) (Open Access)
Isabelle A. van Zeventer, Aniek O. de Graaf, Joop H. Jansen, Gerwin Huls   +3 more
openaire   +5 more sources