Results 61 to 70 of about 187,916 (412)

Clonal hematopoiesis [PDF]

Seminars in Hematology, 2017
Cancer results from multistep pathogenesis, yet the pre-malignant states that precede the development of many hematologic malignancies have been difficult to identify. Recent genomic studies of blood DNA from tens of thousands of people have revealed the presence of remarkably common, age-associated somatic mutations in genes associated with ...
Max, Jan, Benjamin L, Ebert, Siddhartha, Jaiswal   +2 more
openaire   +2 more sources

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis [PDF]

, 2014
Although hematopoietic precursor activity can be generated in vitro from human embryonic stem cells, there is no solid evidence for the appearance of multipotent, self-renewing and transplantable hematopoietic stem cells.
De Bleser, Dominique, De Mulder, Katrien, Kerre, Tessa, Lambrecht, Bart, Leclercq, Georges, Menten, Björn, Philippé, Jan, Taghon, Tom, Van Caeneghem, Yasmine, Van Roy, Nadine, Vandekerckhove, Bart, Vanhee, Stijn, Velghe, Imke, Verstichel, Greet   +13 more
core   +3 more sources

Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8+ T Cells in the Lungs

Frontiers in Immunology, 2019
Tissue-resident memory CD8+ T (TRM) cells that develop in the epithelia at portals of pathogen entry are important for improved protection against re-infection.
Felix M. Behr, Felix M. Behr, Natasja A. M. Kragten, Thomas H. Wesselink, Benjamin Nota, Rene A. W. van Lier, Derk Amsen, Regina Stark, Pleun Hombrink, Klaas P. J. M. van Gisbergen, Klaas P. J. M. van Gisbergen   +10 more
doaj   +1 more source

Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age [PDF]

, 1987
Retrospective histologic analyses of bone biopsies and of post mortem samples from normal persons of different age groups, and of bone biopsies of age- and sex-matched groups of patients with primary osteoporosis and aplastic anemia show characteristic ...
B. Frisch, B. Mallmann, Breslow, Burkhardt, Burkhardt, Burkhardt, Burkhardt, Burkhardt, Burkhardt, Byers, Chavassieuz, Delling, Dixon, Frost, G. Kettner, Kerndrup, Lips, M. Schmidmeier, Mantel, Merz, Meunier, Pommer, R. Burkhardt, R. Schlag, Rhinelander, Rutishauser, Th. Gilg, W. Böhm, W. Eisenmenger, Weiss, Whitehouse   +30 more
core   +1 more source

Aging and Hematopoiesis

Clinics in Geriatric Medicine, 2019
In hematopoiesis, mature blood cells, granulocytes, erythrocytes, and megakaryocytes originate from hematopoietic stem cells. With age, changes in hematopoiesis may have clinical consequences: defective immune responses, cytopenias (most commonly anemia and lymphopenia), hematological malignancy, and effects mediated by hematopoietic cells in other ...
Neal S. Young, Emma M. Groarke
openaire   +3 more sources

Studies on reticuloendothelial system and hemato-poiesis, III. Relationship between differentiation of erythroblast and oxygen tension [PDF]

, 1965
For the purpose to clarify the control mechanism of erythroid cell differentiation, the author observed morphologic changes in bone-marrow cells and circulating red cells in phenylhydrazine anemia of rabbits by introducing a mass of red cells into vein ...
Matsuoka, Kenichi
core   +1 more source

LSD1/KDM1A and GFI1B repress endothelial fate and induce hematopoietic fate in induced pluripotent stem cell-derived hemogenic endotheliums

Haematologica
Differentiation of induced pluripotent stem cells (iPSCs) into hematopoietic lineages offers great therapeutic potential. During embryogenesis, hemogenic endothelium (HE) gives rise to hematopoietic stem and progenitor cells through the endothelial-to ...
Huan Zhang, Marten Hansen, Franca di Summa, Marieke von Lindern, Nynke Gillemans, Wilfred F.J. van IJcken, Arthur Flohr Svendsen, Sjaak Philipsen, Bert van der Reijden, Eszter Varga, Emile van den Akker   +10 more
doaj   +1 more source

Lineage-specific and single cell chromatin accessibility charts human hematopoiesis and leukemia evolution

Nature Genetics, 2016
We define the chromatin accessibility and transcriptional landscapes in 13 human primary blood cell types that span the hematopoietic hierarchy. Exploiting the finding that the enhancer landscape better reflects cell identity than mRNA levels, we enable '
M. Corces, Jason D. Buenrostro, Jason D. Buenrostro, Beijing Wu, Peyton Greenside, Steven M. Chan, J. Koenig, M. Snyder, J. Pritchard, J. Pritchard, Anshul Kundaje, W. Greenleaf, R. Majeti, Howard Y. Chang   +13 more
semanticscholar   +1 more source

Hematopoiesis in the Elderly

Hematology, 2004
The effect of age on the hematopoietic system has always been an area of clinical interest. Alterations in lymphocyte immunophenotype and function with age have been clearly demonstrated as has a decrease in neutrophil function. However, controversy continues to surround the significance of unexplained anaemia in the elderly patient and the extent to ...
Armand Keating, Leanne Berkahn
openaire   +2 more sources

Induction of apoptosis by Shikonin through ROS-mediated intrinsic and extrinsic apoptotic pathways in primary effusion lymphoma

Translational Oncology, 2021
Primary effusion lymphoma (PEL) is an incurable non-Hodgkin's lymphoma and novel biology-based treatments are urgently needed in clinical settings. Shikonin (SHK), a napthoquinone derivative, has been used for the treatment of solid tumors.
Md Masud Alam, Ryusho Kariya, Piyanard Boonnate, Azusa Kawaguchi, Seiji Okada   +4 more
doaj