Results 71 to 80 of about 159,775 (264)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Differentiating erythroblasts adapt to mechanical stimulation by upregulation of cholesterol biosynthesis via S1P/SREBP-induced HMGCR expression

Scientific Reports
Understanding how mechanical stress affects erythropoiesis is crucial to produce transfusable erythrocytes in fluid-turbulent bioreactors. We investigated the effects of shear-stress on differentiating CD49d+CD235a+ primary human erythroblasts (EBL) at ...
Giulia Iacono, Asena Abay, Joan S. Gallego Murillo, Francesca Aglialoro, Nurcan Yagci, Eszter Varga, Tieme Bijlsma, Justine Sohler, Kerly Fu, Julie A. Reisz, Amy Argabright, Angelo D’Alessandro, Arthur F. Svendsen, Marieke von Lindern, Emile van den Akker   +14 more
doaj   +1 more source

On the existence and exponential attractivity of a unique positive almost periodic solution to an impulsive hematopoiesis model with delays

, 2015
In this paper, a generalized model of hematopoiesis with delays and impulses is considered. By employing the contraction mapping principle and a novel type of impulsive delay inequality, we prove the existence of a unique positive almost periodic ...
Anh, Trinh Tuan, Van Hien, Le, Van Nhung, Tran   +2 more
core   +1 more source

Gaucher Disease and Myelofibrosis: A Combined Disease or a Misdiagnosis? [PDF]

, 2018
Background: Gaucher disease (GD) and primary myelofibrosis (PMF) share similar clinical and laboratory features, such as cytopenia, hepatosplenomegaly, and marrow fibrosis, often resulting in a misdiagnosis.
Cardarelli, L, Foà, R, Giona, F, Mariani, S, Palumbo, G, Santopietro, M   +5 more
core   +1 more source

Shared and distinct genetic etiologies for different types of clonal hematopoiesis [PDF]

, 2023
Derek W. Brown, Liam D. Cato, Yajie Zhao, Satish K. Nandakumar, Erik L. Bao, Eugene J. Gardner, Aubrey K. Hubbard, Alexander DePaulis, Thomas Rehling, Lei Song, Kai Yu, Stephen J. Chanock, John R. B. Perry, Vijay G. Sankaran, Mitchell J. Machiela   +14 more
openalex   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Parallel detection of SARS‐CoV‐2 epitopes reveals dynamic immunodominance profiles of CD8+ T memory cells in convalescent COVID‐19 donors

Clinical & Translational Immunology, 2022
Objectives High‐magnitude CD8+ T cell responses are associated with mild COVID‐19 disease; however, the underlying characteristics that define CD8+ T cell‐mediated protection are not well understood.
Jet van denDijssel, Ruth R Hagen, Rivka deJongh, Maurice Steenhuis, Theo Rispens, Dionne M Geerdes, Juk Yee Mok, Angela HM Kragten, Mariël C Duurland, Niels JM Verstegen, S Marieke vanHam, Wim JE vanEsch, Klaas PJM vanGisbergen, Pleun Hombrink, Anja tenBrinke, Carolien E van deSandt   +15 more
doaj   +1 more source

Training the Fetal Immune System Through Maternal Inflammation-A Layered Hygiene Hypothesis. [PDF]

, 2020
Over the last century, the alarming surge in allergy and autoimmune disease has led to the hypothesis that decreasing exposure to microbes, which has accompanied industrialization and modern life in the Western world, has fundamentally altered the immune
Apostol, April C, Beaudin, Anna E, Jensen, Kirk DC   +2 more
core  

Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis [PDF]

, 2016
Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage.
Toofan, Parto, Wheadon, Helen
core   +1 more source

Improved Human Erythropoiesis and Platelet Formation in Humanized NSGW41 Mice

Stem Cell Reports, 2016
Human erythro-megakaryopoiesis does not occur in humanized mouse models, preventing the in vivo analysis of human hematopoietic stem cell (HSC) differentiation into these lineages in a surrogate host.
Susann Rahmig, Romy Kronstein-Wiedemann, Juliane Fohgrub, Nicole Kronstein, Aleksandra Nevmerzhitskaya, Martin Bornhäuser, Max Gassmann, Alexander Platz, Rainer Ordemann, Torsten Tonn, Claudia Waskow   +10 more
doaj   +1 more source