Results 81 to 90 of about 187,916 (412)

Positive periodic solutions for systems of impulsive delay differential equations [PDF]

arXiv, 2021
A class of periodic differential $n$-dimensional systems with patch structure with (possibly infinite) delay and nonlinear impulses is considered. These systems incorporate very general nonlinearities and impulses whose signs may vary. Criteria for the existence of at least one positive periodic solution are presented, extending and improving previous ...
arxiv  

Clonal Dominance and Transplantation Dynamics in Hematopoietic Stem Cell Compartments [PDF]

PLoS Comput Biol 13(10): e1005803 (2017), 2017
Hematopoietic stem cells in mammals are known to reside mostly in the bone marrow, but also transitively passage in small numbers in the blood. Experimental findings have suggested that they exist in a dynamic equilibrium, continuously migrating between these two compartments.
arxiv   +1 more source

Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly.

Blood, 2017
Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is derived from a single dominant hematopoietic stem cell lineage. Somatic mutations in candidate driver (CD) genes are thought to be responsible for at least some cases
Florian Zink, S. Stacey, G. Norddahl, M. Frigge, O. Magnusson, I. Jónsdóttir, T. Thorgeirsson, A. Sigurdsson, S. A. Gudjonsson, J. Gudmundsson, J. Jónasson, L. Tryggvadottir, T. Jónsson, A. Helgason, Arnaldur Gylfason, P. Sulem, T. Rafnar, U. Thorsteinsdóttir, D. Gudbjartsson, G. Másson, A. Kong, K. Stefánsson   +21 more
semanticscholar   +1 more source

Interferons in hematopoiesis and leukemia [PDF]

OncoImmunology, 2013
Interferons not only exert a fundamental role during inflammation and immune responses but also modulate the activity of hematopoietic stem cells during homeostatic and demand-adapted hematopoiesis. Identical mechanisms regulate the homeostasis and proliferation of leukemic stem cells (LSCs). Understanding these mechanisms may lead to novel therapeutic
Schürch, Christian M., Riether, Carsten, Ochsenbein, Adrian F.   +2 more
openaire   +3 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

CREB is a critical regulator of normal hematopoiesis and leukemogenesis [PDF]

, 2008
The cAMP-responsive element binding protein (CREB) is a 43-kDa nuclear transcription factor that regulates cell growth, memory, and glucose homeostasis. We showed previously that CREB is amplified in myeloid leukemia blasts and expressed at higher levels
Akashi, Akashi, Bai, Bottazzi, Bruserud, Cheng, Christensen, Conkright, Crans-Vargas, Deepa B. Shankar, Dejah R. Judelson, Desdouets, Deshpande, Elliot M. Landaw, Fried, Fu, Hestdal, Impey, Ingrid Schmid, Jamieson, Jenny Chang, Jerry C. Cheng, Kathleen M. Sakamoto, Kentaro Kinjo, Kim, Kinjo, Kohn, Kondo, Koschmieder, Koya, Krishan, Kwon, Lee, Mayr, Mendoza, Miyoshi, Montminy, Ninomiya, Noriyuki Kasahara, Passegué, Ravi Bhatia, Rehemtulla, Renata Stripecke, Scherr, Shah, Shankar, Shankar, Shaywitz, Stripecke, Traver, Tuschl, Van Etten, Ventura, Winston S. Wu, Wong, Yuan   +55 more
core   +3 more sources

Role of HDACs in normal and malignant hematopoiesis

Molecular Cancer, 2020
Normal hematopoiesis requires the accurate orchestration of lineage-specific patterns of gene expression at each stage of development, and epigenetic regulators play a vital role.
Pan Wang, Zi Wang, Jing Liu
semanticscholar   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

M-Sec facilitates intercellular transmission of HIV-1 through multiple mechanisms

Retrovirology, 2020
Background HIV-1 promotes the formation of tunneling nanotubes (TNTs) that connect distant cells, aiding cell-to-cell viral transmission between macrophages.
Sameh Lotfi, Hesham Nasser, Osamu Noyori, Masateru Hiyoshi, Hiroaki Takeuchi, Yoshio Koyanagi, Shinya Suzu   +6 more
doaj   +1 more source

A PDMP to model the stochastic influence of quiescence dynamics in blood cancers [PDF]

arXiv, 2023
In this article, we will see a new approach to study the impact of a small microscopic population of cancer cells on a macroscopic population of healthy cells, with an example inspired by pathological hematopoiesis. Hematopoiesis is the biological phenomenon of blood cells production by differentiation of cells called hematopoietic stem cells (HSCs ...
arxiv