Results 31 to 40 of about 5,668,323 (316)

A case-control study on cryopreserved versus non-cryopreserved strategies for autologous hematopoietic cell transplantation in multiple myeloma

Journal of Bone Marrow Transplantation and Cellular Therapy
Background: Autologous hematopoietic cell transplantation (aHCT) is a standard treatment for Multiple Myeloma (MM). The classic practice is with cryopreservation of the peripheral blood stem cells (PBSC) in the period from collection to infusion, but ...
Byron Figueroa, Martin Ferrando, Sebastian Galeano, Gabriel Borelli, Eloísa Riva, Alberto Vásquez, Carolina Oliver, Rosanna De Giuda, Silvia Pierri, Leticia Martinez, Melanie Isern, Claudia Martinez, Romina Urrutia, Cristina Otero, Victoria Irigoín, Victoria Remedi, Martina Perdomo, María Mori, Regis Gai, Estefanía López, Virginia Marcalain, Camila Guidali, Laura Bello, Virginia Moraes, Lourdes Viano, Analía Olivera, Carina Lamela, Carla Ambrosini, Silvia Pisano, Juan Ferrari, Jimena Prieto, Raul Gabús, Pablo Muxí, Ana Inés Landoni   +33 more
doaj   +1 more source

Hematopoietic stem cell transplantation

Stem Cells and Cloning: Advances and Applications, 2010
More than 25,000 hematopoietic stem cell transplantations (HSCTs) are performed each year for the treatment of lymphoma, leukemia, immune-deficiency illnesses, congenital metabolic defects, hemoglobinopathies, and myelodysplastic and myeloproliferative syndromes.
Hatzimichael,Eleftheria, Tuthill,Mark
openaire   +5 more sources

Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1 [PDF]

, 2007
Background: AML1/RUNX1 is the most frequently mutated gene in leukaemia and is central to the normal biology of hematopoietic stem and progenitor cells. However, the role of different AML1 isoforms within these primitive compartments is unclear.
Hong, DL, Shinobu Tsuzuki, Tsuzuki, S, Dengli Hong, Enver Tariq, Tsuzuki Shinobu, Matsuo Keitaro, Keitaro Matsuo, Tariq Enver, Hong Dengli, Seto Masao, Rajeev Gupta, Matsuo, K, Gupta Rajeev, Gupta, R, Seto, M, Hong, D, Enver, T, Masao Seto   +18 more
core   +1 more source

Subclinical myocardial changes after hematopoietic stem cell transplantation: limited predictive value of early biomarkers and strain imaging

Cardio-Oncology
Background Cardiotoxicity is a relevant late complication after hematopoietic stem cell transplantation. Early identification of subclinical myocardial injury could allow preventive interventions, yet the optimal diagnostic approach in this setting ...
Ana Carolina Oliver, Federico Superchi, Roberto Superchi, Matilde Canabal, Carolina Errecarte, Ricardo Mosquera, Ada Caneiro, Silvia Pierri, Sebastian Galeano, Eloisa Riva, Laura Bello, Regis Gai, Silvana Jubin, Pablo Muxi   +13 more
doaj   +1 more source

Identification of the niche and phenotype of the first human hematopoietic stem cells [PDF]

, 2014
In various vertebrate species, the dorsal aorta (Ao) is the site of specification of adult hematopoietic stem cells (HSCs). It has been observed that the upregulation of essential hematopoietic transcription factors and the formation of specific intra ...
Stanislav Rybtsov, Anderson, Richard A, Ivanovs, Andrejs, Andrejs Ivanovs, Richard A. Anderson, Turner, Marc L, Marc L. Turner, Alexander Medvinsky, Medvinsky, Alexander, Rybtsov, Stanislav   +9 more
core   +1 more source

Evidence‐Informed Multidisciplinary Consensus Guidance for the Psychosocial Care of Adolescents With High‐Risk Cancer: Recommendations From the Italian Association of Pediatric Hematology and Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adolescents with high‐risk cancer face complex developmental, psychosocial, and ethical challenges that extend beyond disease‐directed treatment. Although international recommendations exist for communication, psychosocial care, pediatric palliative care, survivorship, and shared decision‐making, these have largely evolved within ...
Johanna M. C. Blom, Dorella Scarponi, Giulia Zucchetti, Teresa Perillo, Maria Montanaro, Elisa Marconi, Chiara Rutigliano, Paolo Colavero, Paola Quarello, Marina Bertolotti, Monica Cellini, Carlo Clerici, Maurizio Mascarin, Francesca Bomben, Andrea Ferrari, the expert workgroup   +15 more
wiley   +1 more source

Pediatric-inspired therapy and blinatumomab consolidation improve outcomes in young adults with Philadelphia-like acute lymphoblastic leukemia

Haematologica
Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk subtype of B-cell ALL associated with poor response to induction chemotherapy, suboptimal measurable residual disease (MRD) clearance, and inferior survival outcomes compared to ...
Ibrahim Aldoss, Arthur Li, Diana Knobler, Vaibhav Agrawal, Hoda Pourhassan, Paul Koller, Tamer Othman, Monzr M. Al Malki, Amandeep Salhotra, Karamjeet Sandhu, Haris Ali, Ahmed Aribi, Amanda Blackmon, Brian Ball, Idoroenyi Amanam, Salman Otoukesh, Rick Lin, Julio C. Alvarenga Thiebaud, Sunmin Park, Samer Khaled, Jose Tinajero, Dat Ngo, Zhaohui Gu, Lindsey Murphy, Yazeed Samara, Michelle Afkhami, Andrew Artz, Pamela Becker, Ryotaro Nakamura, Anthony Stein, Stephen Forman, Guido Marcucci, Vinod Pullarkat   +32 more
doaj   +1 more source

Identification of a novel HOOK3-FGFR1 fusion gene involved in activation of the NF-kappaB pathway

Cancer Cell International, 2022
Background Rearrangements involving the fibroblast growth factor receptor 1 (FGFR1) gene result in 8p11 myeloproliferative syndrome (EMS), which is a rare and aggressive hematological malignancy that is often initially diagnosed as myelodysplastic ...
Xuehong Zhang, Furong Wang, Fanzhi Yan, Dan Huang, Haina Wang, Beibei Gao, Yuan Gao, Zhijie Hou, Jiacheng Lou, Weiling Li, Jinsong Yan   +10 more
doaj   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source