Heme oxygenase-1: Equally important in allogeneic hematopoietic stem cell transplantation and organ transplantation? [PDF]
, 2021 The intracellular enzyme heme oxygenase-1 (HO-1) is responsible for the degradation of cell-free (cf) heme. Cfheme, released upon cell damage and cell death from hemoglobin, mitochondria and myoglobin, functions as a powerful damage-associated molecular ...
Verheij, Myrddin +5 more
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In utero hematopoietic cell transplantation for hemoglobinopathies [PDF]
Frontiers in Pharmacology, 2015 In utero hematopoietic cell transplantation (IUHCTx) is a promising strategy to circumvent the challenges of postnatal hematopoietic stem cell (HSC) transplantation. The goal of IUHCTx is to introduce donor cells into a naïve host prior to immune maturation, thereby inducing donor-specific tolerance.
Derderian, S Christopher +4 more
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Sequential anti-cytomegalovirus response monitoring may allow prediction of cytomegalovirus reactivation after allogeneic stem cell transplantation [PDF]
, 2012 Background: Reconstitution of cytomegalovirus-specific CD3+CD8+ T cells (CMV-CTLs) after allogeneic hematopoietic stem cell transplantation (HSCT) is necessary to bring cytomegalovirus (CMV) reactivation under control. However, the parameters determining
Matthias Eder (21135) +74 more
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A survey on cellular and engineered tissue therapies in Europe in 2008 [PDF]
, 2010 Cellular therapy is an evolving investigational treatment modality in regenerative medicine, but little published information is available on its current use.
Martin, Ivan +9 more
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Tumor recognition by natural killer cells in acute myeloid leukemia and after hematopoietic stem cell transplantation [PDF]
, 2005 Natural killer (NK) cell-mediated cytolytic activity against tumors requires the engagement of activating NK cell receptors by the tumor-associated ligands.
Nowbakht, Pegah
core +1 more source
Allogeneic hematopoietic cell transplantation to treat two synchronous hematologic malignancies
, 2022 Allogeneic hematopoietic cell transplantation often represents the only solution for several poor-prognosis hematologic malignancies. The curative strategy for patients with synchronous hematologic disorders is always difficult and, in most cases ...
Enrico Santinelli* +17 more
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Hematology, 2022 Objective To explore the efficacy and safety of thrombopoietin receptor agonists (TPO-RAs) without anti-thymocyte globulin (ATG) in ATG-naïve patients with aplastic anemia (AA) in a real-world setting.Methods We retrospectively evaluated treatment ...
Masaki Iino +3 more
doaj +1 more source
Molecular monitoring of minimal residual disease in two patients with MLL-rearranged acute myeloid leukemia and haploidentical transplantation after relapse [PDF]
, 2012 This report describes the clinical courses of two acute myeloid leukemia patients. Both had MLL translocations, the first a t(10;11)(p11.2;q23) with MLL-AF10 and the second a t(11;19)(q23;p13.1) with MLL-ELL fusion.
Meyer, Claus +23 more
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Hematopoietic stem cells for transplantation [PDF]
Nature Immunology, 2002 Multiple sources of HSCs exist. Here, Verfaillie discusses the long-term engraftment capabilities of each source and the search for ex vivo expansion conditions to allow bulk culture for therapeutic HSC transplantation.
openaire +3 more sources