Results 1 to 10 of about 5,668,323 (316)

Functional SARS-CoV-2-specific T cells of donor origin in allogeneic stem cell transplant recipients of a T-cell-replete infusion: A prospective observational study

Frontiers in Immunology, 2023
In the current post-pandemic era, recipients of an allogeneic hematopoietic stem cell transplant (HCT) deserve special attention. In these vulnerable patients, vaccine effectiveness is reduced by post-transplant immune-suppressive therapy; consequently ...
Corinna La Rosa, Flavia Chiuppesi, Yoonsuh Park, Qiao Zhou, Dongyun Yang, Ketevan Gendzekhadze, Minh Ly, Jing Li, Teodora Kaltcheva, Sandra Ortega Francisco, Miguel-Angel Gutierrez, Haris Ali, Salman Otoukesh, Idoroenyi Amanam, Amandeep Salhotra, Vinod A. Pullarkat, Ibrahim Aldoss, Michael Rosenzweig, Ahmed M. Aribi, Anthony S. Stein, Guido Marcucci, Sanjeet Singh Dadwal, Ryotaro Nakamura, Stephen J. Forman, Monzr M. Al Malki, Don J. Diamond   +25 more
doaj   +1 more source

Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

Nature Communications, 2023
Chimeric antigen receptor (CAR) T cell therapeutic responses are hampered by limited T cell trafficking, persistence, and durable anti-tumor activity in solid tumors. However, these challenges can be largely overcome by relatively unconstrained synthetic
Eric Hee Jun Lee, John P. Murad, Lea Christian, Jackson Gibson, Yukiko Yamaguchi, Cody Cullen, Diana Gumber, Anthony K. Park, Cari Young, Isabel Monroy, Jason Yang, Lawrence A. Stern, Lauren N. Adkins, Gaurav Dhapola, Brenna Gittins, Wen-Chung Chang, Catalina Martinez, Yanghee Woo, Mihaela Cristea, Lorna Rodriguez-Rodriguez, Jun Ishihara, John K. Lee, Stephen J. Forman, Leo D. Wang, Saul J. Priceman   +24 more
doaj   +1 more source

Results from a phase I trial of pembrolizumab plus vorinostat in relapsed/refractory B-cell non-Hodgkin lymphoma

Haematologica, 2023
Outcomes after programmed death-1 (PD-1) blockade in B-cell lymphomas are disappointing with few durable responses. Histone deacetylase inhibitors exhibit favorable immunomodulatory effects and demonstrate synergistic anti-tumor immune responses with ...
James Godfrey, Matthew Mei, Lu Chen, Joo Y. Song, Victoria Bedell, Elizabeth Budde, Saro Armenian, Sandrine Puverel, Liana Nikolaenko, Robert Chen, Shari Daniels, Neena Kennedy, Lacolle Peters, Steven T. Rosen, Stephen J. Forman, Leslie L. Popplewell, Larry W. Kwak, Alex F. Herrera   +17 more
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One novel ACOT7–NPHP4 fusion gene identified in one patient with acute lymphoblastic leukemia: a case report

BMC Medical Genomics, 2022
Background Acute lymphoblastic leukemia (ALL) is a type of heterogeneous hematopoietic malignancy that accounts for approximately 20% of adult ALL. Although ALL complete remission (CR) rate has increased to 85–90% after induction chemotherapy, 40–50% of ...
Xin Zong, Zhijie Kang, Dan Huang, Xuehong Zhang, Yuan Gao, Haina Wang, Weiling Li, Jinsong Yan   +7 more
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Robust SARS-COV-2-specific T-cell immune memory persists long-term in immunocompetent individuals post BNT162b2 double shot

Heliyon, 2022
Background: A robust efficiency of mRNA vaccines against coronavirus disease-2019 has been demonstrated, however, the intended long-term protection against SARS-CoV-2 has been challenged by the waning humoral and cellular immunity over time, leading to a
Anastasia Papadopoulou, Fani Stavridou, Maria Giannaki, Kiriaki Paschoudi, Fani Chatzopoulou, Eleni Gavriilaki, Grigorios Georgolopoulos, Achilles Anagnostopoulos, Evangelia Yannaki   +8 more
doaj   +1 more source

Patient risk stratification and tailored clinical management of post‐transplant CMV‐, EBV‐, and BKV‐infections by monitoring virus‐specific T‐cell immunity

eJHaem, 2021
Background Despite routine post‐transplant viral monitoring and pre‐emptive therapy, viral infections remain a major cause of allogeneic hematopoietic cell transplantation‐related morbidity and mortality.
Anastasia Papadopoulou, Kiriakos Koukoulias, Maria Alvanou, Vassilios K. Papadopoulos, Zoe Bousiou, Vasiliki Kalaitzidou, Fotini S. Kika, Apostolia Papalexandri, Despina Mallouri, Ioannis Batsis, Ioanna Sakellari, Achilles Anagnostopoulos, Evangelia Yannaki   +12 more
doaj   +1 more source

The impact of SARS-CoV2 vaccines on the incidence of graft versus host disease in allogeneic hematopoietic stem cell transplant recipients: a single-center retrospective study

Stem Cell Research & Therapy, 2023
This study reports the incidence of chronic graft versus host disease (GvHD) in allogeneic hematopoietic stem cell transplant (alloHCT) recipients who received SARS-CoV2 vaccination.
Dat Ngo, Jason Chen, Jose Tinajero, Ahmed Aribi, Shukaib Arslan, Guido Marcucci, Ryotaro Nakamura, Monzr M. Al Malki, Stephen J. Forman, Sanjeet Dadwal, Haris Ali   +10 more
doaj   +1 more source

Understanding the Process and Challenges for Return-to-Work Post-Hematopoietic Cell Transplantation from a Musculoskeletal Perspective: A Narrative Review

Occupational Therapy International, 2021
The current paper seeks to inform healthcare professionals on how adapting various components of return to work (RTW) programs that are already in use by other musculoskeletal rehabilitation settings can help optimize return to work process for patients ...
Jaleel Mohammed, Anne Gonzales, Hadeel R. Bakhsh, Volkova Alisa Georgievna, Jayanti Rai, Bindu Kancharla, Shahrukh K. Hashmi   +6 more
doaj   +1 more source

Co-stimulatory signaling determines tumor antigen sensitivity and persistence of CAR T cells targeting PSCA+ metastatic prostate cancer

OncoImmunology, 2018
Advancing chimeric antigen receptor (CAR)-engineered adoptive T cells for the treatment of solid cancers is a major focus in the field of immunotherapy, given impressive recent clinical responses in hematological malignancies.
Saul J. Priceman, Ethan A. Gerdts, Dileshni Tilakawardane, Kelly T. Kennewick, John P. Murad, Anthony K. Park, Brook Jeang, Yukiko Yamaguchi, Xin Yang, Ryan Urak, Lihong Weng, Wen-Chung Chang, Sarah Wright, Sumanta Pal, Robert E. Reiter, Anna M. Wu, Christine E. Brown, Stephen J. Forman   +17 more
doaj   +1 more source

Off-the-shelf CAR natural killer cells secreting IL-15 target spike in treating COVID-19

Nature Communications, 2022
Severe COVID-19 requires immediate and targeted intervention that is efficient against SARS-CoV-2 and its variants. Authors show here the therapeutic potential of engineered natural killer cells that simultaneously express a chimeric antigen receptor ...
Ting Lu, Rui Ma, Wenjuan Dong, Kun-Yu Teng, Daniel S. Kollath, Zhiyao Li, Jinhee Yi, Christian Bustillos, Shoubao Ma, Lei Tian, Anthony G. Mansour, Zhenlong Li, Erik W. Settles, Jianying Zhang, Paul S. Keim, Bridget M. Barker, Michael A. Caligiuri, Jianhua Yu   +17 more
doaj   +1 more source