Results 41 to 50 of about 469,315 (359)

Dexamethasone for Chemotherapy‐Induced Nausea and Vomiting Prevention in Pediatric Patients: International Consensus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An international Delphi panel of experts developed consensus statements to delineate the circumstances where the risks of dexamethasone as an antiemetic do and do not outweigh its benefits. Procedure Experts in supportive care of pediatric patients were invited to participate.
Negar Shavandi, Paula D. Robinson, Shana Jacobs, L. Lee Dupuis, the International Pediatric Dexamethasone Panel, Sameer Bakhshi, Tiene Bauters, Eva Brack, Simone Cesaro, Claire Fosbrook, Jason Freedman, Tamara MacDonald, Eloise Neumann, Venkatraman Radhakrishnan, Rod Rassekh, Florian Slimano, Johnathan Soggee, Joel Thompson, Marianne van de Wetering, Milena Villarroel, Jasper Wong   +20 more
wiley   +1 more source

The rare Hematological disorder; A man with Hemophagocytic Lymphohistiocytosis (HLH)

Caspian Journal of Internal Medicine, 2021
Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare disease with different causes. HLH has been categorized into two sub-groups; primary HLH which is associated with some gene mutations and secondary HLH that is developed by various causes ...
Majid Gholizadeh, Shirin Kianersi, Leila Noorazar, Vahid Kaveh, Elham Roshandel, Sina Salari   +5 more
doaj  

Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation [PDF]

, 2014
Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic analysis, combining global occupancy
Fujiwara, Yuko, Guo, Guoji, Hsu, Yu-Jung, Kerenyi, Marc A, Luc, Sidinh, Nguyen, Minh, O'Brien, Kassandra, Orkin, Stuart H, Peng, Cong, Shao, Zhen   +9 more
core   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Comparison between different reduced intensity conditioning regimens in AML/MDS patients in a Latin American center of adult stem cell transplantation

Hematology
Background: Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for several hematological diseases. Prospective and retrospective studies have associated myeloablative conditioning regimens with increased non-relapse ...
José Salinas, Yorman Flores, Patricio Rojas, Catherine Gutierrez, Marcela Vidal, Verónica Jara, James Campbell, María José García, Vicente Sandoval, Maximiliano Vergara, Mauricio Ocqueteau, Felipe Palacios, Mauricio Sarmiento   +12 more
doaj   +1 more source

Low WT1 transcript levels at diagnosis predicted poor outcomes of acute myeloid leukemia patients with t(8;21) who received chemotherapy or allogeneic hematopoietic stem cell transplantation

Chinese Journal of Cancer, 2016
Background Acute myeloid leukemia (AML) with t(8;21) is a heterogeneous disease. Identifying AML patients with t(8;21) who have a poor prognosis despite achieving remission is important for determining the best subsequent therapy.
Ya-Zhen Qin, Yu Wang, Hong-Hu Zhu, Robert Peter Gale, Mei-Jie Zhang, Qian Jiang, Hao Jiang, Lan-Ping Xu, Huan Chen, Xiao-Hui Zhang, Yan-Rong Liu, Yue-Yun Lai, Bin Jiang, Kai-Yan Liu, Xiao-Jun Huang   +14 more
doaj   +1 more source

Effect in supralethally irradiated rats of granulocyte colony- stimulating factor and lisofylline on hematopoietic reconstitution by syngeneic bone marrow or whole organ passenger leukocytes [PDF]

, 1997
We have previously shown the existence of migratory hematopoietic stem cells in adult solid organs. This study demonstrates that granulocyte colony- stimulating factor (G-CSF) and lisofylline, a phosphatidic acid inhibitor that suppresses hematopoiesis ...
Abdul Rao, Angus W. Thomson, Anthony J. Demetris, Berry, Bociek, Clarke, Fontes, Foster, Foster, Lieschke, Lyman, Masanobu Terakura, Moore, Murase, Murase, Noriko Murase, Qing Ye, Schuening, Singer, Starzl, Tanikawa, Thomas E. Starzl, Toshiki Sakamoto, Uckun   +23 more
core   +1 more source

The Role of Invasive Procedures in the Treatment of Complicated Gastrointestinal Graft‐Versus‐Host Disease in Pediatric Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Gastrointestinal graft‐versus‐host disease (GI GVHD) following hematopoietic stem cell transplant is typically managed with medical therapy, but surgery and angioembolization may be warranted in selected cases with life‐threatening complications.
Gaia Brunetti, Giorgio Persano, Chiara Grimaldi, Pier Luigi Di Paolo, Carmen Malaspina, Francesco Quagliarella, Valerio Balassone, Anna Chiara Iolanda Contini, Gian Luigi Natali, Rita Alaggio, Ivan Pietro Aloi, Tamara Caldaro, Alessandro Crocoli   +12 more
wiley   +1 more source

Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice [PDF]

, 2016
The mechanistic target of rapamycin (mTOR) signalling pathway plays a highly conserved role in aging; mice lacking ribosomal protein S6 kinase 1 (S6K1-/-) have extended lifespan and healthspan relative to wild type (WT) controls. Exactly how reduced mTOR
Irvine, Elaine E., Michie, Alison M., Pedroni, Silvia M.A., Selman, Colin, Sinclair, Amy, Withers, Dominic J.   +5 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source