Results 61 to 70 of about 276,679 (267)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Sequential anti-cytomegalovirus response monitoring may allow prediction of cytomegalovirus reactivation after allogeneic stem cell transplantation

, 2012
Background: Reconstitution of cytomegalovirus-specific CD3+CD8+ T cells (CMV-CTLs) after allogeneic hematopoietic stem cell transplantation (HSCT) is necessary to bring cytomegalovirus (CMV) reactivation under control. However, the parameters determining
Matthias Eder (21135), Borchers, Sylvia, Benno Wölk, Sylvia Borchers, Arnold Ganser, Pabst, Brigitte, Mischak-Weissinger, Eva Maria, Michael Stadler, Elke Dammann, Andrea Jarisch, Lehrnbecher, Thomas, Arnold Ganser (4454), Eva M. Weissinger (111202), Meral Yildiz, Schneider, Gisbert, Matthias Eder, Peter Bader, Melanie Bremm (111153), Koehl, Ulrike, Thomas Klingebiel, Michael Stadler (111171), Ulrike Koehl, Hans Martin, Benno Wölk (111163), Stadler, Michael, Thomas Lehrnbecher, Sylvia Borchers (111150), Wölk, Benno, Hans Martin (111179), Meral Yildiz (111168), Dammann, Elke, Thomas Klingebiel (111191), Brigitte Pabst (111160), Bader, Peter, Eder, Matthias, Jarisch, Andrea, Brigitte Pabst, Gisbert Schneider, Elke Dammann (111158), Gisbert Schneider (17096), Ulrike Koehl (111209), Thomas Lehrnbecher (111156), Klingebiel, Thomas, Esser, Ruth, Eva M. Weissinger, Ruth Esser (111165), Ganser, Arnold, Yildiz, Meral, Melanie Bremm, Peter Bader (111174), Eva M Weissinger, Bremm, Melanie, Andrea Jarisch (111185), Ruth Esser, Weissinger, Eva M., Köhl, Ulrike, Martin, Hans   +56 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

EDTA‐induced pseudothrombocytopenia in hematopoietic stem cell donor

Clinical Case Reports, 2023
We herein report a case of peripheral blood stem cell transplantation (PBSCT) involving a donor with EDTA‐induced pseudothrombocytopenia (PTCP). The apheresis product was inspected for 24 h and there was no platelet clumping or thrombocytopenia.
Misato Tsubokura, Minoru Kojima, Saori Nakabayashi, Noriko Takahashi, Sayaka Takeuchi, Yu Aruga, Chiaki Ikeda, Naoki Maezawa, Koji Okazaki, Sanshiro Uchida, Mizuki Watanabe, Jun Aoki, Ayumu Ito, Takashi Tanaka, Yoshihiro Inamoto, Sung‐Won Kim, Hiromichi Matsushita, Takahiro Fukuda   +17 more
doaj   +1 more source

Hematopoietic chimerism after allogeneic stem cell transplantation : a comparison of quantitative analysis by automated DNA sizing and fluorescent in situ hybridization

, 2005
Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is performed mainly in patients with high-risk or advanced hematologic malignancies and congenital or acquired aplastic anemias.
Wachowiak, Jacek, Tomasz Strabel, Peter Bader, Bader, Peter, Jólkowska, Justyna, Jacek Wachowiak, Michał Witt, Anna Pieczonka, Strabel, Tomasz, Pieczonka, Anna, Dariusz Boruczkowski, Boruczkowski, Dariusz, Justyna Jółkowska, Witt, Michal   +13 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging

, 2011
Somatic stem cells mediate tissue maintenance for the lifetime of an organism. Despite the well-established longevity that is a prerequisite for such function, accumulating data argue for compromised stem cell function with age.
Nygren, Jens,, Norddahl, Gudmundur,, Wahlestedt, Martin,, Ugale, Amol,, Sigvardsson, Mikael,, Lund University., Sten, Gerd,, Bryder, David,, Pronk, Kees-Jan,   +8 more
core   +1 more source

Regulation of boundary cap neural crest stem cell differentiation after transplantation [PDF]

, 2009
Success of cell replacement therapies for neurological disorders will depend largely on the optimization of strategies to enhance viability and control the developmental fate of stem cells after transplantation.
Hjerling-Leffler, J, Aldskogius, Hakan, Wegner, M, Hjerling-Leffler, Jens, Kozlova, Elena N, Medvinsky, Alexander, Berens, C, Aldskogius, H, Kozlova, EN, Berens, Christian, Kanaykina, Nadezda, Sandelin, Martin, Schreiner, S, Wegner, Michael, Kanaykina, N, Sandelin, M, Liakhovitskaia, A, Medvinsky, A, Liakhovitskaia, Anna, Schreiner, Silke   +19 more
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source