Results 71 to 80 of about 276,679 (267)

Hematopoietic Signaling Mechanism Revealed from a Stem/Progenitor Cell Cistrome

, 2018
Thousands of cis-elements in genomes are predicted to have vital functions. Although conservation, activity in surrogate assays, polymorphisms, and disease mutations provide functional clues, deletion from endogenous loci constitutes the gold-standard ...
Rajendran Sanalkumar, Jin Soo Kim, Chandler Zuo, Yoon-A Kang, Sunduz Keles, Prithvia Devadas, Duk Hyoung Kim, Emery H. Bresnick, Kyle J. Hewitt, Rajalekshmi Prathibha, Kirby D Johnson, Colin N. Dewey   +11 more
core   +1 more source

Hypoxic Culture Conditions as a Solution for Mesenchymal Stem Cell Based Regenerative Therapy [PDF]

, 2014
Cell-based regenerative therapies, based on in vitro propagation of stem cells, offer tremendous hope to many individuals suffering from degenerative diseases that were previously deemed untreatable.
Haque, N., Rahman, M. T., Alabsi, A. M., Abu Kasim, N. H.   +3 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

The association of disease type, pre-transplant hemoglobin level and platelet count with transfusion requirement after autologous hematopoietic stem cell transplantation

Caspian Journal of Internal Medicine, 2021
Background: Autologous hematopoietic stem cell transplantation (auto-HSCT) has become an effective treatment for a wide range of hematologic and non-hematologic diseases.
Shabnam Tabasi, Sayeh Parkhideh, Elham Roshandel, Samira Karami, Anahita Saeedi, Ali Jabbari, Abbas Hajifathali   +6 more
doaj  

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Does size matter? Center-specific characteristics and survival after allogeneic hematopoietic cell transplantation for acute myeloid leukemia: an analysis of the German Registry for Stem Cell Transplantation and Cell Therapy

Haematologica
We investigated the effect of center-specific variables on overall survival (OS) after allogeneic hematopoietic cell transplantation (alloHCT) in acute myeloid leukemia (AML).
Wolfgang Bethge, Sarah Flossdorf, Franziska Hanke, Christoph Schmid, Mark Ringhoffer, Stefan Klein, Bernd Hertenstein, Johannes Schetelig, Matthias Stelljes, Thomas Schroeder, Igor Wolfgang Blau, Francis Ayuk, Matthias Eder, Robert Zeiser, Katharina Fleischhauer, Nicolaus Kröger, Peter Dreger   +16 more
doaj   +1 more source

Feasibility and Safety of IL-15-Activated CD56+ Cell Therapy in High-Risk Acute Myeloid Leukemia after Hematopoietic Stem Cell Transplantation: Phase I Clinical Trial [PDF]

Cell Journal
Objective: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the most effective treatment forpatients with high-risk acute myeloid leukemia (AML), but relapse remains a major challenge. Immunotherapy isconsidered a promising approach
Shiva Eskandarian, Amirhossein Izadpanah, Mozhdeh Mohammadian, Mehdi Bakhtiyaridovvmbaygi, Mehrshad Seresht-Ahmadi, Sahar Parkhideh, Elham Roshandel, Ahmad Gharehbaghian, Abbas Hajifathali   +8 more
doaj   +1 more source

Perforin gene transfer into hematopoietic stem cells improves immune dysregulation in murine models of perforin deficiency

, 2015
Defects in perforin lead to the failure of T and NK cell cytotoxicity, hypercytokinemia, and the immune dysregulatory condition known as familial hemophagocytic lymphohistiocytosis (FHL).
Montiel-Equihua, CA, Arumugam, P, Carmo, M, Risma, KA, Blundell, MP, Hontz, AE, Jordan, MB, Gaspar, HB, Malik, P, Thrasher, AJ, Tiwari, S, Schambach, A, Baum, C, Alonso-Ferrero, ME   +13 more
core