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Aging of hematopoietic stem cells [PDF]

Blood, 2018
AbstractHematopoietic stem cells (HSCs) ensure a balanced production of all blood cells throughout life. As they age, HSCs gradually lose their self-renewal and regenerative potential, whereas the occurrence of cellular derailment strongly increases. Here we review our current understanding of the molecular mechanisms that contribute to HSC aging.
Gerald de Haan, Seka Simone Lazare
openaire   +5 more sources

Natural estrogens enhance the engraftment of human hematopoietic stem and progenitor cells in immunodeficient mice [PDF]

Haematologica, 2020
Hematopoietic Stem and Progenitor Cells are crucial in the maintenance of lifelong production of all blood cells. These Stem Cells are highly regulated to maintain homeostasis through a delicate balance between quiescence, self-renewal and ...
Sara Fañanas-Baquero, Israel Orman, Federico Becerra Aparicio, Silvia Bermudez de Miguel, Jordi Garcia Merino, Rosa Yañez, Yolanda Fernandez Sainz, Rebeca Sánchez, Mercedes Dessy-Rodríguez, Omaira Alberquilla, David Alfaro, Agustin Zapata, Juan A. Bueren, Jose Carlos Segovia, Oscar Quintana-Bustamante   +14 more
doaj   +5 more sources

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis [PDF]

Haematologica, 2015
Although hematopoietic precursor activity can be generated in vitro from human embryonic stem cells, there is no solid evidence for the appearance of multipotent, self-renewing and transplantable hematopoietic stem cells.
Stijn Vanhee, Katrien De Mulder, Yasmine Van Caeneghem, Greet Verstichel, Nadine Van Roy, Björn Menten, Imke Velghe, Jan Philippé, Dominique De Bleser, Bart N. Lambrecht, Tom Taghon, Georges Leclercq, Tessa Kerre, Bart Vandekerckhove   +13 more
doaj   +5 more sources

The Impact of Mesenchymal Stem Cells on Differentiation of Hematopoietic Stem Cells [PDF]

Advanced Pharmaceutical Bulletin, 2015
Bone marrow microenvironment contains cellular and acellular compartments. The cellular compartment includes hematopoietic stem cells, mesenchymal stem cells and some other stromal cell types, while the acellular compartment is composed of scaffold ...
Mahshid Saleh, karim Shamsasanjan, Aliakbar Movassaghpourakbari, Parvin Akbarzadehlaleh, Zahra Molaeipour   +4 more
doaj   +2 more sources

Differentiation and proliferation of hematopoietic stem cells

Blood, 1993
Available evidence indicates that qualitative changes in hematopoietic stem cells and progenitors, such as the decision of stem cells to self-renew or differentiate, or selection of lineage potentials by the multipotential progenitors during ...
Megumu Ogawa
openalex   +2 more sources

Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo

Molecular Cancer, 2023
Background Acute leukemias represent deadly malignancies that require better treatment. As a challenge, treatment is counteracted by a microenvironment protecting dormant leukemia stem cells. Methods To identify responsible surface proteins, we performed
Ehsan Bahrami, Jan Philipp Schmid, Vindi Jurinovic, Martin Becker, Anna-Katharina Wirth, Romina Ludwig, Sophie Kreissig, Tania Vanessa Duque Angel, Diana Amend, Katharina Hunt, Rupert Öllinger, Roland Rad, Joris Maximilian Frenz, Maria Solovey, Frank Ziemann, Matthias Mann, Binje Vick, Christian Wichmann, Tobias Herold, Ashok Kumar Jayavelu, Irmela Jeremias   +20 more
doaj   +1 more source

A reporter system for enriching CRISPR/Cas9 knockout cells in technically challenging settings like patient models

Scientific Reports, 2021
CRISPR/Cas9 represents a valuable tool to determine protein function, but technical hurdles limit its use in challenging settings such as cells unable to grow in vitro like primary leukemia cells and xenografts derived thereof (PDX).
Wen-Hsin Liu, Kerstin Völse, Daniela Senft, Irmela Jeremias   +3 more
doaj   +1 more source

Hematopoietic Stem Cells [PDF]

, 2006
Hematopoietic stem cells (HSCs) have the capacity to self-renew and the potential to differentiate into all of the mature blood cell types. The ability to prospectively identify and isolate HSCs has been the subject of extensive investigation since the first transplantation studies implying their existence almost 50 years ago.
Teresa S. Hawley, Ali Ramezani, Robert G. Hawley   +2 more
openaire   +4 more sources

Virus-Specific T Cells: Promising Adoptive T Cell Therapy Against Infectious Diseases Following Hematopoietic Stem Cell Transplantation [PDF]

Advanced Pharmaceutical Bulletin, 2023
Hematopoietic stem cell transplantation (HSCT) is a life-saving therapy for various hematologic disorders. Due to the bone marrow suppression and its long recovery period, secondary infections, like cytomegalovirus (CMV), Epstein-Bar virus (EBV), and ...
Arsalan Jalili, Abbas Hajifathali, Mozhdeh Mohammadian, Ghazaleh Sankanian, Maryam Sayahinouri, Mahmoud Dehghani Ghorbi, Elham Roshandel, Nasser Aghdami   +7 more
doaj   +1 more source

Promiscuous Expression of H2B-GFP Transgene in Hematopoietic Stem Cells [PDF]

, 2008
The study of adult stem cells relies on the ability to isolate them using complex combinations of markers for flow cytometry. A recent study has used a tetracycline-regulatable H2B-GFP transgenic mouse model analogous to BrdU pulse-chase methods to ...
Challen, Grant A., Goodell, Margaret A.
core   +9 more sources