Results 1 to 10 of about 1,162,311 (403)

Autophagy maintains the metabolism and function of young and old (hematopoietic) stem cells

Nature, 2017
With age, haematopoietic stem cells lose their ability to regenerate the blood system, and promote disease development. Autophagy is associated with health and longevity, and is critical for protecting haematopoietic stem cells from metabolic stress ...
Theodore T. Ho, M. Warr, Emmalee R Adelman, Olivia M Lansinger, J. Flach, E. Verovskaya, M. Figueroa, E. Passegué   +7 more
semanticscholar   +1 more source

Stem Cell Antigen CD34 In Native And Engineered Form Alter Its Binding Ability To Stromal Cells And Ligands: A Classical Example Of Clinical Benefits Of Therapeutic Genetic Engineering Of Stem Cells In Transplantation [PDF]

, 2010
CD34 is a highly glycosylated surface-expressed sialomucin and, because it is present on hematopoietic stem cells (HSCs), has demonstrated immense clinical utility in their enumeration in aphaeresis products, immunoaffinity purification for ...
Gurudutta Gangenahalli, Neeraj Kumar Satija, Pallavi Gupta, Rajendra Prasad Tripathi, Vimal Kumar Singh, Yogesh Kumar Verma   +5 more
core   +2 more sources

CREB is a critical regulator of normal hematopoiesis and leukemogenesis [PDF]

, 2008
The cAMP-responsive element binding protein (CREB) is a 43-kDa nuclear transcription factor that regulates cell growth, memory, and glucose homeostasis. We showed previously that CREB is amplified in myeloid leukemia blasts and expressed at higher levels
Akashi, Akashi, Bai, Bottazzi, Bruserud, Cheng, Christensen, Conkright, Crans-Vargas, Deepa B. Shankar, Dejah R. Judelson, Desdouets, Deshpande, Elliot M. Landaw, Fried, Fu, Hestdal, Impey, Ingrid Schmid, Jamieson, Jenny Chang, Jerry C. Cheng, Kathleen M. Sakamoto, Kentaro Kinjo, Kim, Kinjo, Kohn, Kondo, Koschmieder, Koya, Krishan, Kwon, Lee, Mayr, Mendoza, Miyoshi, Montminy, Ninomiya, Noriyuki Kasahara, Passegué, Ravi Bhatia, Rehemtulla, Renata Stripecke, Scherr, Shah, Shankar, Shankar, Shaywitz, Stripecke, Traver, Tuschl, Van Etten, Ventura, Winston S. Wu, Wong, Yuan   +55 more
core   +3 more sources

Hematopoietic Stem Cells and Their Roles in Tissue Regeneration

International Journal of Stem Cells, 2019
Hematopoietic stem cells (HSCs) are regarded as one of essential cell sources for treating regenerative diseases. Among many stem cells, the feasibility of using adult-derived hematopoietic stem cells in therapeutic approaches is very diverse, and is ...
Ji Yoon Lee, Seok-Ho Hong
semanticscholar   +1 more source

Zebrafish Caudal Haematopoietic Embryonic Stromal Tissue (CHEST) Cells Support Haematopoiesis. [PDF]

, 2017
Haematopoiesis is an essential process in early vertebrate development that occurs in different distinct spatial locations in the embryo that shift over time.
Aggio, Julian, Campbell, Clyde, Marquez, Gabriel, Stachura, David L, Traver, David, Wolf, Anja, Wright, Francis   +6 more
core   +1 more source

Regulation of stress-induced hematopoiesis [PDF]

, 2015
Purpose of review: Hematopoietic stem cells can self-renew and also give rise to the entire repertoire of hematopoietic cells. During acute infectious and inflammatory stresses, the hematopoietic system can quickly adapt to demand by increasing output of
Baltimore, David, Zhao, Jimmy L.
core   +1 more source

Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells

Stem Cells International, 2019
Quiescent and self-renewing hematopoietic stem cells (HSCs) rely on glycolysis rather than on mitochondrial oxidative phosphorylation (OxPHOS) for energy production. HSC reliance on glycolysis is considered an adaptation to the hypoxic environment of the
Luena Papa, Mansour Djedaini, R. Hoffman
semanticscholar   +1 more source

Osteoblast Derived Exosomes Alleviate Radiation- Induced Hematopoietic Injury

Frontiers in Bioengineering and Biotechnology, 2022
As hematopoietic stem cells can differentiate into all hematopoietic lineages, mitigating the damage to hematopoietic stem cells is important for recovery from overdose radiation injury.
Jianqi Xue, Jianqi Xue, Ruikai Du, Shukuan Ling, Jinping Song, Xinxin Yuan, Caizhi Liu, Weijia Sun, Yuheng Li, Guohui Zhong, Yinbo Wang, Guodong Yuan, Xiaoyan Jin, Zizhong Liu, Dingsheng Zhao, Youyou Li, Wenjuan Xing, Yuanyuan Fan, Zifan Liu, Junjie Pan, Zhen Zhen, Yunzhang Zhao, Qinna Yang, Jianwei Li, Yan-Zhong Chang, Yingxian Li   +25 more
doaj   +1 more source

Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

Genome Research, 2015
Both intrinsic cell state changes and variations in the composition of stem cell populations have been implicated as contributors to aging. We used single-cell RNA-seq to dissect variability in hematopoietic stem cell (HSC) and hematopoietic progenitor ...
Monika S. Kowalczyk, I. Tirosh, D. Heckl, T. N. Rao, Atray C Dixit, B. Haas, R. Schneider, A. Wagers, B. Ebert, A. Regev   +9 more
semanticscholar   +1 more source

Tianshengyuan-1 (TSY-1) regulates cellular Telomerase activity by methylation of TERT promoter. [PDF]

, 2016
Telomere and Telomerase have recently been explored as anti-aging and anti-cancer drug targets with only limited success. Previously we showed that the Chinese herbal medicine Tianshengyuan-1 (TSY-1), an agent used to treat bone marrow deficiency, has a ...
Chow, Michelle, Jin, Yusheng, Li, Yawei, Qin, Xiaotian, Rao, Jianyu, Santiskulvong, Chintda, Vu, Victor, Yu, Weibo, Zeng, Gang, Zhang, Zuofeng   +9 more
core   +2 more sources