Induction in myeloid leukemic cells of genes that are expressed in different normal tissues [PDF]
PNAS 101, 16022 (2004), 2005 Using DNA microarray and cluster analysis of expressed genes in a cloned line (M1-t-p53) of myeloid leukemic cells, we have analyzed the expression of genes that are preferentially expressed in different normal tissues. Clustering of 547 highly expressed genes in these leukemic cells showed 38 genes preferentially expressed in normal hematopoietic ...
arxiv +1 more source
Mathematical modelling, selection and hierarchical inference to determine the minimal dose in IFN$α$ therapy against Myeloproliferative Neoplasms [PDF]
Mathematical Medicine and Biology: A Journal of the IMA, Volume
41, Issue 2, June 2024, Pages 110-134, 2021 Myeloproliferative Neoplasms (MPN) are blood cancers that appear after acquiring a driver mutation in a hematopoietic stem cell. These hematological malignancies result in the overproduction of mature blood cells and, if not treated, induce a risk of cardiovascular events and thrombosis. Pegylated IFN$\alpha$ is commonly used to treat MPN, but no clear
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Clonal Dominance and Transplantation Dynamics in Hematopoietic Stem Cell Compartments [PDF]
PLoS Comput Biol 13(10): e1005803 (2017), 2017 Hematopoietic stem cells in mammals are known to reside mostly in the bone marrow, but also transitively passage in small numbers in the blood. Experimental findings have suggested that they exist in a dynamic equilibrium, continuously migrating between these two compartments.
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Dynamics of a Mathematical Hematopoietic Stem-Cell Population Model [PDF]
Journal on Applied Dynamical Systems, 18 (2019), 808-852, 2017 We explore the bifurcations and dynamics of a scalar differential equation with a single constant delay which models the population of human hematopoietic stem cells in the bone marrow. One parameter continuation reveals that with a delay of just a few days, stable periodic dynamics can be generated of all periods from about one week up to one decade ...
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Bayesian inference and model choice in a hidden stochastic two-compartment model of hematopoietic stem cell fate decisions [PDF]
Annals of Applied Statistics 2009, Vol. 3, No. 4, 1695-1709, 2010 Despite rapid advances in experimental cell biology, the in vivo behavior of hematopoietic stem cells (HSC) cannot be directly observed and measured. Previously we modeled feline hematopoiesis using a two-compartment hidden Markov process that had birth and emigration events in the first compartment.
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A PDMP to model the stochastic influence of quiescence dynamics in blood cancers [PDF]
arXiv, 2023 In this article, we will see a new approach to study the impact of a small microscopic population of cancer cells on a macroscopic population of healthy cells, with an example inspired by pathological hematopoiesis. Hematopoiesis is the biological phenomenon of blood cells production by differentiation of cells called hematopoietic stem cells (HSCs ...
arxiv
Hematopoietic cancers and Nup98 fusions: determining common mechanisms of malignancy [PDF]
, 2012 Chromosomal aberrations are very frequent in leukemias and several recurring mutations capable of malignant transformation have been described. These mutations usually occur in hematopoietic stem cells (HSC), transforming them into leukemia stem cells.
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A Structured Population Model of Cell Differentiation [PDF]
SIAM Journal on Applied Mathematics 71, 6 (2011) 1918-1940, 2010 We introduce and analyze several aspects of a new model for cell differentiation. It assumes that differentiation of progenitor cells is a continuous process. From the mathematical point of view, it is based on partial differential equations of transport type. Specifically, it consists of a structured population equation with a nonlinear feedback loop.
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Regression-Based Analysis of Multimodal Single-Cell Data Integration Strategies [PDF]
arXiv, 2023 Multimodal single-cell technologies enable the simultaneous collection of diverse data types from individual cells, enhancing our understanding of cellular states. However, the integration of these datatypes and modeling the interrelationships between modalities presents substantial computational and analytical challenges in disease biomarker detection
arxiv
Periodic solutions for a nonautonomous mathematical model of hematopoietic stem cell dynamics [PDF]
arXiv, 2020 The main purpose of this paper is to study the existence of periodic solutions for a nonautonomous differential-difference system describing the dynamics of hematopoietic stem cell (HSC) population under some external periodic regulatory factors at the cellular cycle level.
arxiv