Results 131 to 140 of about 1,175,170 (409)

T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38−/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells

Haematologica, 2011
Background Human bone marrow and umbilical cord blood are sources of allogeneic hematopoietic stem cells for transplantation, which is a life-saving treatment in a variety of diseases but is burdened by delayed T-cell reconstitution.
Magda De Smedt, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre, Tom Taghon, Jean Plum   +5 more
doaj   +1 more source

Fgd5 identifies hematopoietic stem cells in the murine bone marrow

Journal of Experimental Medicine, 2014
Fdg5 identifies bone marrow cells with potent hematopoietic stem cell activity.
R. Gazit, P. Mandal, Wataru Ebina, A. Ben-Zvi, C. Nombela-Arrieta, L. Silberstein, Derrick J. Rossi   +6 more
semanticscholar   +1 more source

Hematopoietic Stem Cells and Hematopoiesis

Cancer Control, 2003
Background The highly orchestrated process of blood cell development and homeostasis is termed “hematopoiesis.” Understanding the biology of hematopoietic stem cells as well as hematopoiesis is important to developing improved treatments for hematologic malignancies, congenital disorders, chemotherapy-related cytopenias, and blood and marrow ...
openaire   +2 more sources

Preclinical Evaluation of Thrombopoietin and Flt-3 ligand Treatment [PDF]

, 2003
The hematopoietic system is a cell renewal system in which mature peripheral blood cells with a limited life span are continuously replenished by proliferation and differentiation of lineage-specific progenitor cells derived from scarce pluripotent ...
Hartong, S.C.C. (Simone)
core   +1 more source

Maintenance of Leukemia-Initiating Cells Is Regulated by the CDK Inhibitor Inca1

, 2015
Functional differences between healthy progenitor and cancer initiating cells may provide unique opportunities for targeted therapy approaches. Hematopoietic stem cells are tightly controlled by a network of CDK inhibitors that govern proliferation and ...
Berdel, W.E. (Wolfgang), Berkenfeld, F. (Frank), Bäumer, N. (Nicole), Bäumer, S.A. (Sebastian), Köhler, G. (Gabriele), Müller-Tidow, C. (Carsten), Stehling, M. (Martin), Tschanter, P.M. (Petra)   +7 more
core   +1 more source

Three‐Year Follow‐Up of Neoadjuvant Tislelizumab with Chemotherapy in Locally Advanced Gastric and Gastroesophageal Junction Adenocarcinoma: Revealing Cancer‐Associated Fibroblast Heterogeneity Corresponding to PD‐1 Blockade Efficacy

Advanced Science, EarlyView.
Heterogeneous cancer‐associated fibroblasts orchestrate dual immune microenvironments in LAGC. Abstract The potential for immunotherapy in patients with locally advanced gastric cancer (LAGC) is recently confirmed. To report the 3‐year follow‐up data are aimed from a novel clinical trial. This is a prospective single‐arm phase II trial.
Yao Lin, Xiong Sun, Chengguo Li, Ming Yang, Ke Wu, Ke Liu, Anshu Li, Xiaoming Shuai, Kailin Cai, Zheng Wang, Guobin Wang, Peng Zhang, Jianfeng Shen, Kaixiong Tao, Yuping Yin   +14 more
wiley   +1 more source

P094 | HIGH-SENSITIVITY DETECTION OF LOW ALLELE FREQUENCY V617F VARIANT IN THE JAK2 GENE USING DIGITAL PCR (DPCR): A NOVEL TOOL FOR DIAGNOSIS OF MYELOPROLIFERATIVE NEOPLASMS

Haematologica
Accurate quantification of the V617F variant in the JAK2 gene using highly sensitive technologies is crucial for the diagnosis, therapeutic monitoring and prognostic assessment of patients with myeloproliferative neoplasms (MPNs).
N. Codeluppi, E. Ronda, A. Schiro, E. Borotti, S. Guidotti, E. Follini, A. Rossi, D. Vallisa   +7 more
doaj  

Collection and composition of autologous peripheral blood stem cells graft in patients with acute myeloid leukemia: influence on hematopoietic recovery and outcome [Skupljanje i sastav transplantata autolognih krvotvornih matičnih stanica periferne krvi u bolesnika s akutnom mijeloičnom leukemijom: utjecaj na hematološki oporavak i ishod] [PDF]

, 2010
Hematopoietic stem cell (HSC) transplantation is a standard approach in the treatment of hematological malignant diseases. For the last 15 years the main source of cells for trasplantation have been peripheral blood stem cells (PBSC).
Batinić, Drago, Bojanić, Ines, Dubravčić, Klara, Dušak, Vesna, Golubić-Ćepulić, Branka, Labar, Boris, Mazić, Sanja, Mrsić, Mirando, Nemet, Damir, Raos, Mirela, Sertić, Dubravka, Serventi-Seiwerth, Ranka   +11 more
core  

Mesenchymal Stem Cell‐Derived Extracellular Vesicles Modulate the Course of Peritoneal Inflammation Through Metabolic and Epigenetic Regulation

Advanced Science, EarlyView.
MSC‐EVs alleviate peritoneal inflammation and fibrogenesis by disrupting the H3K18la‐CCL2 axis and crosstalk between mesothelial cells and Ly6c2⁺ macrophages. Model cartoons are constructed using the Biorender website (https://www.biorender.com/), and a usage license is obtained. Abstract Peritoneal dialysis (PD), as a renal replacement therapy, relies
Qiang Huang, Yuxiang Sun, Pengpeng Kuang, Juan Sun, Dandan Guo, Long Peng, Hu Zhou, Qinrong Song, Zhihao Huo, Canming Li, Janusz Witowski, Zhaoyong Hu, Hui Peng   +12 more
wiley   +1 more source

Efficacy and safety of camrelizumab plus apatinib for solid tumors: a meta-analysis

Frontiers in Immunology
ObjectiveThis study used meta-analysis to explore the efficacy and safety of camrelizumab plus apatinib in the treatment of solid tumors.MethodsPubMed, Embase, web of science, and Cochrane library databases were searched for this study, and the searches ...
Ping Yu, Xiaoyu Song, Xiaoyu Song, Yue Li, Xuanlong Chen, Xuanlong Chen, Yuan Zhou, Yuan Zhou, Fei Jiang   +8 more
doaj   +1 more source