Results 151 to 160 of about 217,775 (266)

ATP2B1 expression identifies human hematopoietic stem cells with superior repopulation and self-renewal. [PDF]

Proc Natl Acad Sci U S A
Varesi A, Nagree MS, Di Biasio I, Zeng AGX, Shah S, Zhang M, Kim H, Murison A, Badami R, Gan O, Jin L, McLeod J, Abraham SA, Minden MD, Arruda A, Novitzky-Basso I, Mattsson J, Dick JE, Xie SZ.   +18 more
europepmc   +1 more source

Human Monocytic Models Reveal Genotype‐Dependent Inflammatory Programs in VEXAS Syndrome

Arthritis &Rheumatology, EarlyView.
Objective VEXAS syndrome is a severe X‐linked autoinflammatory disorder caused by somatic mutations in ubiquitin‐like modifier activating enzyme 1 (UBA1), with clinical outcomes that vary by UBA1 genotype. We aimed to elucidate genotype‐specific inflammatory programs and identify potential therapeutic targets.
Kana Higashitani, Tatsuma Ban, Yohei Kirino, Go R. Sato, Soichiro Adachi, Yuki Iizuka, Kayo Harita, Ayaka Maeda, Osamu Ohara, Hideaki Nakajima, Tomohiko Tamura   +10 more
wiley   +1 more source

Clinical Trial Landscape of Gene-Edited Autologous Hematopoietic Stem Cells for Hemoglobinopathies and Immunodeficiencies. [PDF]

Int J Mol Sci
O'Hanlon Cohrt K, O'Dea S.
europepmc   +1 more source

Oral Azacitidine Maintenance After CPX‐351 in Transplant‐Ineligible Patients With Therapy‐Related or Myelodysplasia‐Related Acute Myeloid Leukemia

American Journal of Hematology, EarlyView.
Caroline Fileni, Edmond Chiche, David Swoboda, Alexander Coltoff, Rami Komrokji, Geoffrey Uy, Sarah Bertoli, Lenaig Le Clech, Mael Heiblig, Ludovic Gabellier, Patrick Lawrence, Lydia Kretschmer, Christoph Röllig, A. H. Wei, Fabio Guolo, Roberto Massimo Lemoli, Jeffrey Lancet, David Sallman, Thomas Cluzeau   +18 more
wiley   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Metal-Free Induced Tandem Cyclization of 2‑Aryl‑N‑Methacryloyl Indoles via 1,2-Hydrogen Atom Transfer

ACS Omega
Peng Chen, Wanting Peng, Xingqin Tian, Shuying Li, Fang Ye, Guanghui Lv   +5 more
doaj   +1 more source

CHEK2 loss endows chemotherapy resistance to hematopoietic stem cells. [PDF]

Leukemia
Zhou J, Hu T, Li D, Li S, Li M, Shi X, Nakada D.   +6 more
europepmc   +1 more source

Affinity Peptides With pH Sensitivity for the Enrichment of CD38+ Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The selective enrichment of cell populations based on surface markers is critical for the advancement of gene and cell therapies. Current antibody‐based cell isolation methods, such as fluorescence‐ and magnetic‐activated cell sorting (FACS and MACS), offer high specificity but are limited by scalability, cost, and potential adverse effects on
Gabrielle Rusch, Mickael Meyer, I. Mohamed Irfan, Carson Huber, Joseph Burclaff, Scott T. Magness, Stefano Menegatti, Michael Daniele   +7 more
wiley   +1 more source

Single-cell vector copy number analysis of phenotypically defined long-term hematopoietic stem cells for gene therapy safety assessment. [PDF]

Mol Ther Adv
Sato Y, Matsushima SK, Shimada Y, Kobayashi H.   +3 more
europepmc   +1 more source

Isolating T‐Cell Potent Lentiviral Vector Subpopulations through Rational Design of Nanofiber Anion‐Exchange Adsorbents

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Generation of CAR‐T cell therapies relies predominantly on lentiviral vectors (LVs). As in vivo CAR‐T trials progress, demand for larger quantities of higher‐potency LV is expected. However, primary capture by anion‐exchange chromatography (AIEX) remains a major manufacturing bottleneck from use of adsorbents not tailored to LVs, leading to ...
George Pamenter, Gyorgy Ovari, Anurag Kulkarni, Thomas Williams‐Fegredo, Carol Knevelman, Kyriacos Mitrophanous, Lee Davies, Farzad Foroutan, Matthew Townsend, Stephen Goldrick, Daniel G. Bracewell   +10 more
wiley   +1 more source