Results 141 to 150 of about 1,175,170 (409)

Hypoxia Regulates Lymphoid Development of Human Hematopoietic Progenitors

Cell Reports, 2019
Summary: Hypoxia plays a major role in the physiology of hematopoietic and immune niches. Important clues from works in mouse have paved the way to investigate the role of low O2 levels in hematopoiesis. However, whether hypoxia impacts the initial steps
Sara Chabi, Benjamin Uzan, Irina Naguibneva, Julien Rucci, Lucine Fahy, Julien Calvo, Marie-Laure Arcangeli, Frédéric Mazurier, Françoise Pflumio, Rima Haddad   +9 more
doaj   +1 more source

The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation [PDF]

, 2016
Ke Zhao, Qifa Liu
openalex   +1 more source

Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia

Nature Genetics, 2014
Cell fate can be controlled through asymmetric division and segregation of protein determinants, but the regulation of this process in the hematopoietic system is poorly understood. Here we show that the dynein-binding protein Lis1 is critically required
Bryan Zimdahl, Bryan Zimdahl, Takahiro Ito, Allen R. Blevins, Jeevisha Bajaj, T. Konuma, Joi Weeks, Claire S. Koechlein, H. Kwon, Omead Arami, D. Rizzieri, H. Broome, C. Chuah, C. Chuah, V. Oehler, R. Sásik, G. Hardiman, G. Hardiman, T. Reya   +18 more
semanticscholar   +1 more source

Microvascular Health as a Key Determinant of Organismal Aging

Advanced Science, EarlyView.
This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini, Andrea Uccelli, Francesca Mangili, Myriam Grunewald, Simone Bersini   +4 more
wiley   +1 more source

P1367: COMPARISON CONDITIONING REGIMENS (BEEAC,LEAM,CLV) BEFORE AUTOLOGOUS STEM CELL TRANSPLANTATION FOR TREATMENT OF PRIMARY-REFRACTORY AND RELAPSED FORMS HODGKIN’S LYMPHOMA

HemaSphere, 2022
A. Samoylova, V. Sarzhevskiy, V. Melnichenko, N. Mochkin, A. Rukavitsyn, E. Smirnova, V. Bogatyrev, A. Bannikova   +7 more
doaj   +1 more source

Combined multiplex polymerase chain reaction-based targeted next−generation sequencing and serum 1, 3-β-D-glucan for differential diagnosis of Pneumocystis pneumonia and Pneumocystis colonization

Frontiers in Cellular and Infection Microbiology
Background and ObjectivePneumocystis jirovecii pneumonia (PjP) remains an important cause of morbimortality worldwide, and differentiating Pneumocystis jirovecii (P. jirovecii) infection from P.
Hansheng Wang, Xiao Chen, Xiaofeng Wu, Qizhen Cao, Yi Wu, Fang Wang, Yunyun Wang, Yanhui Zhou, Yijun Tang, Tao Ren, Meifang Wang   +10 more
doaj   +1 more source

Deleterious effect of bone marrow-resident macrophages on hematopoietic stem cells in response to total body irradiation [PDF]

, 2022
Marion Chalot, Vilma Barroca, Saiyirami Devanand, Françoise Hoffschir, Paul‐Henri Roméo, Stéphanie Moreno   +5 more
openalex   +1 more source

Hematopoietic Stem Cell Heterogeneity

, 2019
Hematopoietic stem cells (HSCs) maintain lifelong production of mature blood cells and regenerate the hematopoietic system after cytotoxic injury. Use of expanding cell surface marker panels and advanced functional analyses have revealed the presence of several immunophenotypically different HSC subsets with distinct self-renewal and repopulating ...
openaire   +3 more sources

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, EarlyView.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

Plasticity in growth behavior of patients' acute myeloid leukemia stem cells growing in mice

Haematologica, 2020
Sarah Ebinger, Christina Zeller, Michela Carlet, Daniela Senft, Johannes W. Bagnoli, Wen-Hsin Liu, Maja Rothenberg-Thurley, Wolfgang Enard, Klaus H. Metzeler, Tobias Herold, Karsten Spiekermann, Binje Vick, Irmela Jeremias   +12 more
doaj   +1 more source