Results 261 to 270 of about 1,162,311 (403)

Research advancements and evaluation of multifactor‐induced murine models for gastric cancer

Animal Models and Experimental Medicine, EarlyView.
Murine models for gastric cancer. Abstract As one of the most prevalent gastrointestinal malignancies in humans, gastric cancer (GC) is often detected at an advanced stage, resulting in a poor prognosis and ranking it the fifth leading cause of cancer‐related deaths.
Yiqing Wang, Liang Zhang, Weixu Feng, Wanfeng Liu, Xiangyang Xue, Shiyu Feng   +5 more
wiley   +1 more source

EMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism and alleviating endoplasmic reticulum stress. [PDF]

Nat Commun
Li L, Lei Y, Li Y, Xie Y, Hui P, Zang X, Wu W, Wu F, Fan J, Wang J, Chen J, Chen Z, Hou Y.   +12 more
europepmc   +1 more source

Intensive Chemoradiotherapy and Autologous Hematopoietic Stem Cell Transplantation in the Treatment of Lymphoma [PDF]

, 1991
Joseph W. Fay
openalex   +1 more source

The Vietnamese swine as a translational model of invasive ductal carcinoma of the breast

Animal Models and Experimental Medicine, EarlyView.
The flow diagram outlines the chemical induction of breast tumors through a single intraperitoneal dose of MNU. Tumor development was assessed using ultrasound and clinical examination. After 14 weeks, mammary tissue was collected and histologically analyzed to evaluate structural similarities between sows and humans, the carcinogenic potential of MNU,
Claudia Elizabeth Vera‐Tizatl, Arturo Vera‐Hernández, Lorenzo Leija‐Salas, Marco Antonio Vega‐López, María del Carmen Ramírez‐Estudillo, German Isauro Garrido Fariña, Adriana Leticia Vera‐Tizatl   +6 more
wiley   +1 more source

Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities. [PDF]

Stem Cell Res Ther
Liao Y, Octaviani S, Tian Z, Wang SR, Huang C, Huang J.   +5 more
europepmc   +1 more source

New approaches to treating chronic obstructive pulmonary disease with Colla corii asini

Animal Models and Experimental Medicine, EarlyView.
Colla corii asini improves chronic obstructive pulmonary disease (COPD) treatment through anti‐inflammatory, antioxidant, immune‐modulatory, and lung‐nourishing effects, addressing current therapeutic challenges via multitarget mechanisms. Abstract Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death and disability ...
Wenchao Zhang, Siman Sun, Xiaoyu Fan, Jiuming He, Qing Li, Hongtao Jin   +5 more
wiley   +1 more source

Imbalanced TGFβ signalling and autophagy drive erythroid priming of hematopoietic stem cells in β-thalassemia. [PDF]

Nat Commun
Lidonnici MR, Chianella G, Mende N, Bastos HP, Barcella M, Merelli I, Storto M, Romeo V, Tiboni F, Scaramuzza S, Rossi C, Raggi L, Aprile A, Crippa S, Iskander D, Roberts I, Karamiditris A, Keith J, Lechauve C, Weiss MJ, Wilson NK, Göttgens B, Bernardo ME, Ciceri F, Aiuti A, Marktel S, Laurenti E, Ferrari G.   +27 more
europepmc   +1 more source

Phorbol ester induced ex vivo expansion of rigorously-defined phenotypic but not functional human cord blood hematopoietic stem cells: a cautionary tale demonstrating that phenotype does not always recapitulate stem cell function [PDF]

, 2019
Broxmeyer, Hal E., Chen, Yandan, Guo, Bin, Huang, Xinxin, Jiang, Rongzhen, Liu, Sheng, Teng, Yincheng, Wan, Jun, Yao, Chunxu   +8 more
core   +1 more source

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

Cell, 2009
S. Jaiswal, C. Jamieson, W. Pang, Christopher Y. Park, M. Chao, R. Majeti, D. Traver, N. Rooijen, I. Weissman   +8 more
semanticscholar   +1 more source

Identification of a Proteolysis‐Targeting‐Chimera that Addresses Activated Checkpoint Kinase‐1 Reveals its Non‐Catalytic Functions in Tumor Cells

Angewandte Chemie International Edition, EarlyView.
In cancer cells, the induction of DNA replication stress by HU activates CHK1 by autophosphorylation. This leads to cell cycle arrest and recruits the DNA repair protein WRN to promote DNA repair and cell survival. In such cells, addition of the CHK1 inhibitor 9a propels DNA damage and apoptosis.
Ramy Ashry, Mohamed Abdelsalam, Julia Hausen, Christoph Hieber, Yanira Zeyn, Anne‐Christin Sarnow, Matthias Schmidt, Sara Najafi, Ina Oehme, Matthias Bros, Jia‐Xuan Chen, Mario Dejung, Wolfgang Sippl, Oliver H. Krämer   +13 more
wiley   +1 more source