Results 271 to 280 of about 224,203 (310)

Hematopoietic Stem Cells and Aging

Science of Aging Knowledge Environment, 2002
Hematopoiesis is a process by which a single cell--called a hematopoietic stem cell (HSC)--has the proliferative potential to give rise to all of the major lineages of blood and immune cells. Stem cells can undergo both symmetric division, which results in two copies of the parent stem cell, and asymmetric division, which results in self-renewal of the
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The aging of hematopoietic stem cells

Nature Medicine, 1996
We have purified hematopoietic stem cells (HSCs) from the bone marrow of old mice and compared their properties to HSCs in young and middle-aged mice. Single, reconstituting HSCs (by limit dilution) from old and young mice exhibited indistinguishable progenitor activities in vivo. HSCs were five times as frequent in the bone marrow of old mice; however,
S J, Morrison, A M, Wandycz, K, Akashi, A, Globerson, I L, Weissman   +4 more
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Hematopoietic Stem-Cell Transplantation

New England Journal of Medicine, 2006
Hematopoietic stem-cell transplantation, which is used to treat both malignant and nonmalignant conditions, was first conceived more than 50 years ago, but problems associated with transplanting a nonsolid organ and modulating the immune response had to be solved before the procedure could be used clinically.
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Hematopoietic stem cells: An overview

Transfusion and Apheresis Science, 2014
Considerable efforts have been made in recent years in understanding the mechanisms that govern hematopoietic stem cell (HSC) origin, development, differentiation, self-renewal, aging, trafficking, plasticity and transdifferentiation. Hematopoiesis occurs in sequential waves in distinct anatomical locations during development and these shifts in ...
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Heterogeneity of hematopoietic stem cells

Current Opinion in Immunology, 1993
Hematopoietic stem cells are capable of multi-lineage differentiation to all blood cell types as well as self-renewal and radioprotection. Thy-1.1lo Lin-/lo Sca-1+ cells are a heterogeneous mixture of quiescent and self-renewing hematopoietic stem cells as well as multi-lineage expanding cells.
N, Uchida, W H, Fleming, E J, Alpern, I L, Weissman   +3 more
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Hematopoietic Stem Cells Therapies

Current Stem Cell Research & Therapy, 2016
Stem cell-based therapies are recognized as a new way to treat various diseases and injuries, with a wide range of health benefits. The goal is to heal or replace diseased or destroyed organs or body parts with healthy new cells provided by stem cell transplantation.
Mihaela, Chivu-Economescu, Martin, Rubach   +1 more
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Hematopoietic stem cells and their niche

Trends in Immunology, 2005
Recent evidence indicates that osteoblasts are crucial components of the particular microenvironments, or niches, for hematopoietic stem cells (HSCs) in adult bone marrow (BM). Stem cells persist in an immature state within the BM. The quiescence of HSCs is controlled dynamically by the signaling of receptors-ligands and cell-adhesion molecules.
Toshio, Suda, Fumio, Arai, Atsushi, Hirao   +2 more
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Thrombopoietin and the Hematopoietic Stem Cell

Blood, 1998
Abstract: The molecular mechanisms that underlie the favorable effects of thrombopoietin on stem cell survival, self‐renewal, and expansion are unknown. On the basis of known effects of HoxB4, HoxA9, and vascular endothelial cell growth factor on stem cells, we explored whether TPO might affect these pathways.
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Hematopoietic stem cell donation

International Journal of Hematology, 2013
Allogeneic hematopoietic stem cell transplantation is now an important treatment for numerous diseases. Donation of hematopoietic stem cells, either through bone marrow (BM) harvesting or peripheral blood stem cell (PBSC) collection, is a well-established and generally accepted procedure.
Shu-Huey, Chen, Tso-Fu, Wang, Kuo-Liang, Yang   +2 more
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Plasticity of hematopoietic stem cells

Best Practice & Research Clinical Haematology, 2015
Almost two decades ago, a number of cell culture and preclinical transplantation studies suggested the striking concept of the tissue-reconstituting ability of hematopoietic stem cells (HSCs). While this heralded an exciting time of radically new therapies for disorders of many organs and tissues, the concept was soon mired by controversy and remained ...
Makio, Ogawa, Amanda C, LaRue, Meenal, Mehrotra   +2 more
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