Results 271 to 280 of about 1,207,844 (359)

Kidney Hematopoietic Stem and Progenitor Cells Contribute to Myeloid Development and Pathology in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in nonlymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi, Seyoung Jung, Jeong Ho Joo, Young‐Eun Kim, Heounjeong Go, Yong‐Gil Kim, Chang‐Keun Lee, Bin Yoo, Jeong Seok Lee, Seokchan Hong   +9 more
wiley   +1 more source

Nanoengineered 3D culture substrate enables superior persistence and polyclonal engraftment of genetically engineered hematopoietic stem cells.

Cell Stem Cell
Midena F, Alessandrini L, Conci C, Barcella M, Gazzo F, Jacchetti E, Carsana E, Benedicenti F, Vacca R, Della Volpe L, Arévalo S, Giannetti K, Barozzi D, Franchino M, Zonari E, Ferrua F, Farina G, Brombin C, Cugnata F, Fiumara M, Tavella T, Cherubin L, Fraschetta F, Cerullo G, Osellame R, Radrizzani M, Ferrari S, Merelli I, Gentner B, Scielzo C, Brendolan A, Naldini L, Aiuti A, Montini E, Raimondi MT, Di Micco R.   +35 more
europepmc   +1 more source

Gene therapy supports long-term reconstitution of patient hematopoietic stem cells in deficiency of adenosine deaminase 2. [PDF]

Mol Ther Methods Clin Dev
Rigamonti C, Bulté D, Barzaghi F, Mesa-Nuñez C, Basso-Ricci L, Pettinato E, Visconti C, Degl'Innocenti S, Gazzo F, Benedicenti F, Arévalo S, Quaranta P, Sanvito F, Caorsi R, Schena F, Lupia M, Federici S, Insalaco A, De Benedetti F, Scala S, Miano M, Conti F, Cicalese MP, Montini E, Gattorno M, Dufour C, Aiuti A, Mortellaro A.   +27 more
europepmc   +1 more source

Inflammation‐driven variability in drug metabolism: Insights from voriconazole treatment of HSCT recipients

British Journal of Clinical Pharmacology, EarlyView.
Aims Voriconazole is commonly used to prevent fungal infections after haematopoietic stem cell transplantation (HSCT). Although its metabolism is influenced by CYP2C19 genetics and inflammation, their combined effect is rarely considered in clinical practice, and integrated analyses remain limited.
Sylvia D. Klomp, Martijn L. Manson, Henk‐Jan Guchelaar, Stefan Böhringer, Esther H. M. van Egmond, Peter A. von dem Borne, Jesse J. Swen   +6 more
wiley   +1 more source

Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity. [PDF]

Cell Stem Cell
Xavier Raj I, Kyun Koh W, Harrison J, Zhang CR, Soares B, Amato R, Krishnan A, O'Leary DR, Bjeije H, Parsons TM, Han W, Young AL, Wang T, Batista LFZ, Challen GA.   +14 more
europepmc   +1 more source

Affinity Peptides With pH Sensitivity for the Enrichment of CD38+ Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The selective enrichment of cell populations based on surface markers is critical for the advancement of gene and cell therapies. Current antibody‐based cell isolation methods, such as fluorescence‐ and magnetic‐activated cell sorting (FACS and MACS), offer high specificity but are limited by scalability, cost, and potential adverse effects on
Gabrielle Rusch, Mickael Meyer, I. Mohamed Irfan, Carson Huber, Joseph Burclaff, Scott T. Magness, Stefano Menegatti, Michael Daniele   +7 more
wiley   +1 more source

Erratum: Super-resolution imaging informed scRNA sequencing analysis reveals the critical role of GDF15 in rejuvenating aged hematopoietic stem cells. [PDF]

Blood Sci
Shi Z, Zhang X, Yang H, Zheng X, Niu M, Zhang Y, Yuan P, Wei W, Huang G, Fang R, Chen L.   +10 more
europepmc   +1 more source

Harnessing Cellular Feeling: Epigenetic to Mechanical Memory as a Framework for Stem Cell Manufacturing

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Stem cell‐based therapies hold transformative potential for regenerative medicine, yet their progress is constrained by persistent variability in manufacturing and clinical performance. Conventional frameworks such as Quality by Design (QbD), though effective for drugs and biologics, struggle to accommodate the dynamic nature of living cell ...
Mee‐Hae Kim, Masahiro Kino‐oka
wiley   +1 more source

Author Correction: Clonal evolution of hematopoietic stem cells after autologous stem cell transplantation. [PDF]

Nat Genet
Uryu H, Saeki K, Haeno H, Kapadia CD, Furudate K, Nangalia J, Spencer Chapman M, Zhang L, Padilla J, Zhao L, Hsu JI, Zhao C, Chen S, Tanaka T, Li Z, Ogata S, Hanache S, Yang H, DiNardo C, Daver N, Pemmaraju N, Jain N, Ravandi F, Zhang J, Song X, Thompson E, Tang H, Little L, Gumbs C, Orlowski RZ, Qazilbash M, Bhalla K, Colla S, Kantarjian H, Kanagal-Shamanna R, Bueso-Ramos C, Nakada D, Al-Atrash G, Molldrem J, Futreal PA, Shpall E, Goodell M, Garcia-Manero G, Takahashi K.   +43 more
europepmc   +1 more source

Hematopoietic Stem Cells Require Elevated Protein Quality Control [PDF]

, 2018
Dillingham, Christopher, Hatters, Danny, Hong, Yuning, Kruta, Miriama, San Jose, Lorena Hidalgo, Signer, Robert, Sunshine, Mary Jean   +6 more
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