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Characterization of Hematopoietic Stem Cells

Annals of the New York Academy of Sciences, 1995
On the basis of density-separated mononuclear cells isolated from bone marrow, peripheral blood, and cord blood, we have repeatedly shown good correlation between two-color flow cytometric (FACS) CD34 analysis and colony formation in the clonogenic assay.
G, Fritsch   +7 more
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Hematopoietic stem cell aging

Current Opinion in Immunology, 2014
Aging is organized in a hierarchy, in which aging of cells results in aged tissues, ultimately limiting lifespan. For organ systems that also in the adult depend on stem cells for tissue homeostasis like the hematopoietic system that forms immune cells, it is believed that aging of the stem cells strongly contributes to aging-associated dysfunction. In
Hartmut, Geiger   +2 more
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Hematopoietic Stem Cells

Pediatrics, 2004
The hematopoietic system of the young child acquires, through time, the ability to cope with exposure to a number of environmental toxins and infectious agents. Occasionally, severe aplastic anemia occurs secondary to exposure to some of these toxins or infectious agents.
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Hematopoietic stem cells

Birth Defects Research Part C: Embryo Today: Reviews, 2003
AbstractConsiderable effort has been made in recent years in defining the embryonic origin of the hematopoietic stem cell (HSC). Using transgenic mouse models, a number of genes that regulate the formation, self‐renewal, or differentiation of HSCs have been identified. Of particular interest, it has recently been shown that key regulators of definitive
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Mobilization of hematopoietic stem cells

Blood Reviews, 2000
Hematopoietic stem cell transplantation has been extensively exploited as a therapeutic and research modality and has revolutionized current patient care. At present, more and more medical centers use peripheral blood progenitor cells for transplantation by mobilizing hematopoietic stem cells from bone marrow to peripheral blood because of potential ...
S, Fu, J, Liesveld
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Hematopoietic stem cells

Current Biology, 1992
Recent studies indicate that hematopoietic stem cells that provide long-term reconstitution can be separated from more mature hematopoietic cells that provide radioprotection and short-term repopulation. With these findings it is now possible to design assays that will specifically measure long-term repopulating stem cells, as well as to develop ...
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Neovascularization and Hematopoietic Stem Cells

Cell Biochemistry and Biophysics, 2011
Vasculogenesis and angiogenesis are the major forms of blood vessel formation. Angiogenesis is the process where new vessels grow from pre-existing blood vessels, and is very important in the functional recovery of pathological conditions, such as wound healing and ischemic heart diseases. The development of better animal model and imaging technologies
Jingwei, Lu   +2 more
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Hematopoietic Stem Cells and Aging

Experimental Gerontology, 1999
The question of whether hematopoietic stem cells are altered in aging has been the subject of considerable controversy for over two decades. The substantial advancement of knowledge on hematopoietic stem cells and developmental hematology in the last few years has reopened this issue for critical analysis.
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Hematopoietic stem-cell differentiation

Current Opinion in Immunology, 1991
Hematopoietic stem cells can be identified and isolated from hematopoietic tissues of mammalian hosts. Assay systems that solely reflect hematopoietic stem cell activity are being developed, and new cytokines that influence hematopoietic stem-cell proliferation and differentiation have been described.
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Hematopoietic Stem Cell Transplantation

Hospital Practice, 1993
The isolation, purification, and in vitro expansion of the hematopoietic stem cell have allowed pretransplant immunologic and genetic manipulation. As a result, rapid allogeneic or autologous hematologic reconstitution with minimal graft-versus-host disease is possible in patients receiving high-dose chemotherapy.
S, Jagannath, B, Barlogie, G, Tricot
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