Results 241 to 250 of about 1,207,844 (359)

Posttransplantation clonal dynamics of hematopoietic stem cells carrying prenatal and early-life <i>DNMT3A</i> mutations. [PDF]

Hemasphere
Derks LLM, Müskens KF, van Roosmalen MJ, de Graaf AO, Epskamp N, Trabut L, Hagelaar R, Jansen JH, Lindemans CA, van Bergen MGJM, van Boxtel R, Belderbos ME.   +11 more
europepmc   +1 more source

Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells.

Blood, 2015
Megan D Hoban, G. Cost, M. Mendel, Z. Romero, Michael L Kaufman, Alok V. Joglekar, Michelle W L Ho, Dianne Lumaquin, David Gray, Georgia R Lill, Aaron R Cooper, F. Urbinati, S. Senadheera, A. Zhu, Pei‐Qi Liu, David E. Paschon, Lei Zhang, E. Rebar, A. Wilber, Xiaoyan Wang, P. Gregory, M. Holmes, A. Reik, R. Hollis, D. Kohn   +24 more
semanticscholar   +1 more source

Complementary multi‐omics profiling of chronic thromboembolic pulmonary hypertension reveals immune cell alterations, epigenetic changes, and genetically supported candidate genes

Animal Models and Experimental Medicine, EarlyView.
This study presents an integrative multi‐omics framework to uncover the molecular mechanisms and potential biomarkers of chronic thromboembolic pulmonary hypertension (CTEPH). Anthropometric and biochemical data were correlated using canonical correlation analysis, revealing key cardiometabolic associations. Single‐cell RNA sequencing identified immune
Xiaopeng Liu, Xia Zheng, Yajun Zhang, Yinghui Fang, Yanan Zhen   +4 more
wiley   +1 more source

Harnessing DNA barcoding to enhance and sustain polyclonality in gene-edited hematopoietic stem cells. [PDF]

Mol Ther Methods Clin Dev
Ojeda-Perez I, Bustos A, Selvaraj S, Fañanas-Baquero S, Alberquilla-Fernandez O, Serrano LJ, Bonafont J, Garcia-Torralba A, Torres-Ruiz R, Rodriguez-Perales S, Lang V, Trigueros C, Mayo-Garcia R, Quintana-Bustamante O, Porteus M, Sánchez-Dominguez R, Segovia JC.   +16 more
europepmc   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle.

Cell Stem Cell, 2014
Isabel Beerman, J. Seita, M. Inlay, I. Weissman, Derrick J. Rossi   +4 more
semanticscholar   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Engineered hematopoietic stem cells give rise to therapeutic antibody secreting B cells

Porteus M, Luna S, Feist W, Utz A, Afaghani J, Miyauchi M, Ghanim H, Ekman F, Amaya A, Selvaraj S, Russkamp N, Schmiderer L.   +11 more
europepmc   +1 more source

AP2M1 Amplification Orchestrates Notch-Mediated Chemoresistance in Hematopoietic Stem Cells of Acute Myeloid Leukemia Patients. [PDF]

Adv Sci (Weinh)
Lee H, Kim EK, Ju HY, Lee CR, Ahn S, Kim ES, Myung K, Kim WK, Cho SY, Kwon Y, Kim D, Yu Y, Kwon EJ, Kim H, Mun SI, Lim DM, Kim K, Heo HJ, Baek SE, Lee SY, Cho H, Choi EY, Goh TS, Baryawno N, Lee D, Jung KS, Yoo KH, Oh CK, Kim YH.   +28 more
europepmc   +1 more source

Somatic Mutations in Acquired Pure Red Cell Aplasia: Incidence and Implications

American Journal of Hematology, EarlyView.
Robert T. Means Jr
wiley   +1 more source