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Heterogeneity of hematopoietic stem cells
Current Opinion in Immunology, 1993Hematopoietic stem cells are capable of multi-lineage differentiation to all blood cell types as well as self-renewal and radioprotection. Thy-1.1lo Lin-/lo Sca-1+ cells are a heterogeneous mixture of quiescent and self-renewing hematopoietic stem cells as well as multi-lineage expanding cells.
N, Uchida +3 more
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Hematopoietic Stem Cells Therapies
Current Stem Cell Research & Therapy, 2016Stem cell-based therapies are recognized as a new way to treat various diseases and injuries, with a wide range of health benefits. The goal is to heal or replace diseased or destroyed organs or body parts with healthy new cells provided by stem cell transplantation.
Mihaela, Chivu-Economescu +1 more
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Hematopoietic stem cells and their niche
Trends in Immunology, 2005Recent evidence indicates that osteoblasts are crucial components of the particular microenvironments, or niches, for hematopoietic stem cells (HSCs) in adult bone marrow (BM). Stem cells persist in an immature state within the BM. The quiescence of HSCs is controlled dynamically by the signaling of receptors-ligands and cell-adhesion molecules.
Toshio, Suda +2 more
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Thrombopoietin and the Hematopoietic Stem Cell
Blood, 1998Abstract: The molecular mechanisms that underlie the favorable effects of thrombopoietin on stem cell survival, self‐renewal, and expansion are unknown. On the basis of known effects of HoxB4, HoxA9, and vascular endothelial cell growth factor on stem cells, we explored whether TPO might affect these pathways.
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Hematopoietic stem cell donation
International Journal of Hematology, 2013Allogeneic hematopoietic stem cell transplantation is now an important treatment for numerous diseases. Donation of hematopoietic stem cells, either through bone marrow (BM) harvesting or peripheral blood stem cell (PBSC) collection, is a well-established and generally accepted procedure.
Shu-Huey, Chen +2 more
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Plasticity of hematopoietic stem cells
Best Practice & Research Clinical Haematology, 2015Almost two decades ago, a number of cell culture and preclinical transplantation studies suggested the striking concept of the tissue-reconstituting ability of hematopoietic stem cells (HSCs). While this heralded an exciting time of radically new therapies for disorders of many organs and tissues, the concept was soon mired by controversy and remained ...
Makio, Ogawa +2 more
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Hematopoietic stem cell expansion
Transfusion Science, 1997This review addresses two issues: (1) cytokine-mediated expansion of functional end cells for the abrogation of short term neutropenia and thrombopenia following high dose chemotherapy and (2) cytokine-driven increase in absolute numbers of functional stem cells.
A, Rice, J, Ripoche, J, Reiers
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The Biology of Hematopoietic Stem Cells
Annual Review of Cell and Developmental Biology, 1995Hematopoietic stem cells (HSC) are the only cells in the blood-forming tissues that can give rise to all blood cell types and that can self-renew to produce more HSC. In mouse and human, HSC represent up to 0.05% of cells in the bone marrow. HSC are almost entirely responsible for the radioprotective and short- and long-term reconstituting effects ...
S J, Morrison, N, Uchida, I L, Weissman
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The biology of hematopoietic stem cells
Archives of Medical Research, 2003Rarely has so much interest from the lay public, government, biotechnology industry, and special interest groups been focused on the biology and clinical applications of a single type of human cell as is today on stem cells, the founder cells that sustain many, if not all, tissues and organs in the body.
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Generation of transgene-free hematopoietic stem cells from human induced pluripotent stem cells
Cell Stem Cell, 2023Hélène Lapillonne +2 more
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