Results 221 to 230 of about 224,203 (310)

Heritable ER stress impairs mitochondrial metabolism and maintenance of hematopoietic stem cells after low-dose irradiation. [PDF]

iScience
Moreno SG, Ferri F, Lewandowski D, Barroca V, Devanand S, Dechamps N, Romeo PH, Gault N.   +7 more
europepmc   +1 more source

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, EarlyView.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Engineered hematopoietic stem cells give rise to therapeutic antibody secreting B cells

Porteus M, Luna S, Feist W, Utz A, Afaghani J, Miyauchi M, Ghanim H, Ekman F, Amaya A, Selvaraj S, Russkamp N, Schmiderer L.   +11 more
europepmc   +1 more source

Ruxolitinib Pharmacokinetics and Exposure–Toxicity Relationship in Hematologic Malignancies and Immune‐Mediated Diseases: A Prospective Observational Study

Clinical Pharmacology &Therapeutics, EarlyView.
Ruxolitinib pharmacokinetics (PK) has been characterized in clinical trials but remains poorly documented in real‐world practice. This project aimed to investigate ruxolitinib PK in routine clinical practice, identify factors driving its variability, and explore exposure–response relationships to assess the potential role of therapeutic drug monitoring.
Jérémie Tachet, Sara C. Meyer, Francesco Grandoni, Emmanuel Haefliger, Monika Nagy‐Hulliger, Jörg P. Halter, Jakob R. Passweg, David Haefliger, Carine Bardinet, Laurent A. Decosterd, Monia Guidi, François R. Girardin   +11 more
wiley   +1 more source

Blood Generation from Hemogenic Endothelium Proven by Continuous Single Cell Imaging

, 2008
Eilken, H., Eilken, Hanna
core  

Establishment of pediatric reference ranges for circulating naïve and memory T and B cell subsets guided by the human immunophenotyping consortium standardization initiative: A large, single center U.S. experience

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley   +1 more source

<i>Mmrn1</i> expression defines a novel subset of hematopoietic stem cells and leukemia stem cells with great self-renewal potential. [PDF]

Haematologica
Chen N, Yang L, Chen F, Zeng H, Zhong X, Liu Y, Chen Z, Yao M, Lu Y, Shen M, Chen M, Xu Y, Wang S, Zhang X, Wang J, Hu M.   +15 more
europepmc   +1 more source

[Hematopoietic stem cell niche].

[Rinsho ketsueki] The Japanese journal of clinical hematology, 2012
openaire   +2 more sources

Circulating monocyte partitioning and its alteration in hematological chronic neoplasms

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Circulating monocyte partitioning refers to the relative quantification of the three main monocyte subsets in the peripheral blood, namely classical (cMo), intermediate (iMo), and non‐classical (ncMo) monocytes, as assessed by flow cytometry, a new nomenclature described 15 years ago.
Sihem Tarfi, Dorothée Selimoglu‐Buet, Ivan Sloma, Orianne Wagner‐Ballon, on behalf of the French group CytHem‐LMMC   +4 more
wiley   +1 more source

Harnessing DNA barcoding to enhance and sustain polyclonality in gene-edited hematopoietic stem cells. [PDF]

Mol Ther Methods Clin Dev
Ojeda-Perez I, Bustos A, Selvaraj S, Fañanas-Baquero S, Alberquilla-Fernandez O, Serrano LJ, Bonafont J, Garcia-Torralba A, Torres-Ruiz R, Rodriguez-Perales S, Lang V, Trigueros C, Mayo-Garcia R, Quintana-Bustamante O, Porteus M, Sánchez-Dominguez R, Segovia JC.   +16 more
europepmc   +1 more source