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Birth Defects Research Part C: Embryo Today: Reviews, 2003
AbstractConsiderable effort has been made in recent years in defining the embryonic origin of the hematopoietic stem cell (HSC). Using transgenic mouse models, a number of genes that regulate the formation, self‐renewal, or differentiation of HSCs have been identified. Of particular interest, it has recently been shown that key regulators of definitive
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AbstractConsiderable effort has been made in recent years in defining the embryonic origin of the hematopoietic stem cell (HSC). Using transgenic mouse models, a number of genes that regulate the formation, self‐renewal, or differentiation of HSCs have been identified. Of particular interest, it has recently been shown that key regulators of definitive
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Characterization of Hematopoietic Stem Cells
Annals of the New York Academy of Sciences, 1995On the basis of density-separated mononuclear cells isolated from bone marrow, peripheral blood, and cord blood, we have repeatedly shown good correlation between two-color flow cytometric (FACS) CD34 analysis and colony formation in the clonogenic assay.
G, Fritsch +7 more
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Current Opinion in Immunology, 2014
Aging is organized in a hierarchy, in which aging of cells results in aged tissues, ultimately limiting lifespan. For organ systems that also in the adult depend on stem cells for tissue homeostasis like the hematopoietic system that forms immune cells, it is believed that aging of the stem cells strongly contributes to aging-associated dysfunction. In
Hartmut, Geiger +2 more
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Aging is organized in a hierarchy, in which aging of cells results in aged tissues, ultimately limiting lifespan. For organ systems that also in the adult depend on stem cells for tissue homeostasis like the hematopoietic system that forms immune cells, it is believed that aging of the stem cells strongly contributes to aging-associated dysfunction. In
Hartmut, Geiger +2 more
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Hematopoietic Stem Cells and Aging
Experimental Gerontology, 1999The question of whether hematopoietic stem cells are altered in aging has been the subject of considerable controversy for over two decades. The substantial advancement of knowledge on hematopoietic stem cells and developmental hematology in the last few years has reopened this issue for critical analysis.
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Hematopoietic Stem Cells and Aging
Science of Aging Knowledge Environment, 2002Hematopoiesis is a process by which a single cell--called a hematopoietic stem cell (HSC)--has the proliferative potential to give rise to all of the major lineages of blood and immune cells. Stem cells can undergo both symmetric division, which results in two copies of the parent stem cell, and asymmetric division, which results in self-renewal of the
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Heterogeneity of hematopoietic stem cells
Current Opinion in Immunology, 1993Hematopoietic stem cells are capable of multi-lineage differentiation to all blood cell types as well as self-renewal and radioprotection. Thy-1.1lo Lin-/lo Sca-1+ cells are a heterogeneous mixture of quiescent and self-renewing hematopoietic stem cells as well as multi-lineage expanding cells.
N, Uchida +3 more
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Hematopoietic Stem Cells Therapies
Current Stem Cell Research & Therapy, 2016Stem cell-based therapies are recognized as a new way to treat various diseases and injuries, with a wide range of health benefits. The goal is to heal or replace diseased or destroyed organs or body parts with healthy new cells provided by stem cell transplantation.
Mihaela, Chivu-Economescu +1 more
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Thrombopoietin and the Hematopoietic Stem Cell
Blood, 1998Abstract: The molecular mechanisms that underlie the favorable effects of thrombopoietin on stem cell survival, self‐renewal, and expansion are unknown. On the basis of known effects of HoxB4, HoxA9, and vascular endothelial cell growth factor on stem cells, we explored whether TPO might affect these pathways.
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Plasticity of hematopoietic stem cells
Best Practice & Research Clinical Haematology, 2015Almost two decades ago, a number of cell culture and preclinical transplantation studies suggested the striking concept of the tissue-reconstituting ability of hematopoietic stem cells (HSCs). While this heralded an exciting time of radically new therapies for disorders of many organs and tissues, the concept was soon mired by controversy and remained ...
Makio, Ogawa +2 more
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Hematopoietic stem cell expansion
Transfusion Science, 1997This review addresses two issues: (1) cytokine-mediated expansion of functional end cells for the abrogation of short term neutropenia and thrombopenia following high dose chemotherapy and (2) cytokine-driven increase in absolute numbers of functional stem cells.
A, Rice, J, Ripoche, J, Reiers
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