Results 201 to 210 of about 217,775 (266)

Engraftment Outcome of CRISPR/Cas9-Edited Hematopoietic Stem Cells for Genetic Diseases: A Systematic Review and Meta-Analysis of Preclinical Evidence. [PDF]

J Hematol
Yadav S, Chakravarti B, Anjum B, Yadav S, Singh PK, Kumar A.   +5 more
europepmc   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Correction to "Posttransplantation clonal dynamics of hematopoietic stem cells carrying prenatal and early-life <i>DNMT3A</i> mutations". [PDF]

Hemasphere
europepmc   +1 more source

Transient mechanical activation of the Piezo1 channel facilitates ex vivo expansion of hematopoietic stem cells. [PDF]

Cell Res
Wang Q, Zeng X, Yang H, Lu H, Jiang L, Xu L, Li J, Li J, Han Y, Wu X, Zhou Y, Chen X, Zhao Y, Shi J, Luo Y, Ni F, Sun J, Zhao Q, Yang F, Xia P, Jiang H, Huang H, Qian P.   +22 more
europepmc   +1 more source

Reversal of Chronic Stress‐Induced Inflammaging by Bazi Bushen Formula Through AMPK‐Sirtuins Axis Activation and Myeloid Reset

Exploration, EarlyView.
Chronic stressors trigger systemic immune remodeling marked by myeloid expansion and lymphoid suppression, and this immune imbalance subsequently drives tissue pathology through proinflammatory signaling and senescence amplification, with the lung and kidney confirmed as the most vulnerable target organs.
Mengnan Li, Zheming Chen, Lu Wang, Zixuan Wang, Shixiong Zhang, Kunxu Niu, Xiaogang Shen, Xuan Lu, Runtao Zhang, Yuning Jiang, Yawen Li, Yi Dai, Xiyang Tang, Bin Hou, Min Shi, Xiaoya Wang, Zhifang Guo, Xingyu Xing, Ning Kang, Hongrong Li, Tianyu Kang, Evelyne Bischof, Yunlong Hou, Zhenhua Jia   +23 more
wiley   +1 more source

The hematopoietic stem cells supportive megakaryocytes as shapers of the bone marrow niche. [PDF]

Eur J Histochem
Arciprete F, Velardi V, Verachi P, Carta C, Di Virgilio A, Roberti V, Vivacqua G, Rana R, Zingariello M.   +8 more
europepmc   +1 more source

Functional correction and genome integrity with duplex base editing of β-thalassemic hematopoietic stem cells. [PDF]

Genome Biol
Papaioannou NY, Patsali P, Klermund J, Papasavva PL, Andrieux G, Koniali L, Naiisseh B, Christou S, Sitarou M, Kleanthous M, Cathomen T, Lederer CW.   +11 more
europepmc   +1 more source

Dietary restriction mitigates 5-fluorouracil-induced thrombocytopenia in aged mice via mitochondrial potentiation in hematopoietic stem cells and megakaryocyte progenitors. [PDF]

Stem Cell Reports
Qiu X, Tang D, Lin J, Chen Z, Qiu R, Wang Q, He S, Zhang S, Zhan Q, Tao Z, Zhang L, Tao S.   +11 more
europepmc   +1 more source

In situ gene editing of hematopoietic stem cells via AAV-delivered CRISPR guide RNAs. [PDF]

Blood Adv
Karimzadeh A, Kim R, Garcia V, Florea M, Peacker BL, Kobayashi S, Watkins D, Messemer K, Zeng J, Bauer DE, Serwold T, Wagers AJ.   +11 more
europepmc   +1 more source

Harnessing DNA barcoding to enhance and sustain polyclonality in gene-edited hematopoietic stem cells. [PDF]

Mol Ther Methods Clin Dev
Ojeda-Perez I, Bustos A, Selvaraj S, Fañanas-Baquero S, Alberquilla-Fernandez O, Serrano LJ, Bonafont J, Garcia-Torralba A, Torres-Ruiz R, Rodriguez-Perales S, Lang V, Trigueros C, Mayo-Garcia R, Quintana-Bustamante O, Porteus M, Sánchez-Dominguez R, Segovia JC.   +16 more
europepmc   +1 more source