Results 201 to 210 of about 1,207,844 (359)

A Bone Marrow–Mimetic Hydrogel Enables Dual‐Phase Hemostasis and Vascularized Osteogenesis for Cranial Defects

Advanced Science, EarlyView.
A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che, Donghong Li, Huan Zhang, Tingting Xu, Juhan Li, Xuanzhou Chen, Louis D. Zhang, Shuguang Wang, Dianwen Song, Dongyong Sha   +9 more
wiley   +1 more source

Lineage bias in hematopoietic stem cells: more niche or intrinsic factors? [PDF]

Haematologica
Hayal TB, Wu C.
europepmc   +1 more source

Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells

Science Translational Medicine, 2016
M. DeWitt, W. Magis, Nicolas L. Bray, Tianjiao Wang, Jennifer R. Berman, F. Urbinati, S. Heo, T. Mitros, Denise P. Muñoz, D. Boffelli, D. Kohn, M. Walters, D. Carroll, D. Martin, J. Corn   +14 more
semanticscholar   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Prospective isolation of mouse and human hematopoietic stem cells using PLXDC2. [PDF]

Commun Biol
Tanaka Y, Kubota Y, Kikuchi R, Yabushita T, Kimura T, Lieberam I, Barlow JL, Bramley JW, Fukushima T, Sakuma C, Shibata T, Nakagawa M, Kurosawa Y, Maruyama T, Okumura CJ, Arima Y, Sato Y, Ono Y, Akuta T, Mizuno H, Kent DG, Jessell TM, Goyama S, Nishikii H, Kimura S, Yamazaki S, Suda T, Kitamura T.   +27 more
europepmc   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Impact of Preanalytical Sample Preparation on the Recovery Rate of Cryopreserved Allogeneic Hematopoietic Stem Cells. [PDF]

Eur J Haematol
Blüm P, Glas C, Bieback K, Kayser S, Klüter H, Wuchter P.   +5 more
europepmc   +1 more source

Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells

Science, 2002
A. Wagers, R. Sherwood, J. Christensen, I. Weissman   +3 more
semanticscholar   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

Targeting RhoA nuclear mechanoactivity rejuvenates aged hematopoietic stem cells. [PDF]

Nat Aging
Mejía-Ramírez E, Picazo PI, Walter B, Montserrat-Vazquez S, Affuso F, Wieser S, Pezzano F, Reymond L, Castillo-Robles J, Matteini F, Mularoni L, Maciá D, Raya Á, Ruprecht V, Zheng Y, Petrone P, Florian MC.   +16 more
europepmc   +1 more source