Results 181 to 190 of about 1,207,844 (359)

Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals.

Immunity, 2016
Catherine M. Sawai, S. Babović, Samik Upadhaya, D. Knapp, Yonit Lavin, Colleen M. Lau, A. Goloborodko, Jue Feng, Joji Fujisaki, Lei Ding, L. Mirny, M. Merad, C. Eaves, B. Reizis   +13 more
semanticscholar   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Hematopoietic (stem) cells-The elixir of life? [PDF]

FEBS Lett
Cerezo EL, Anderson J, Vedrenne ED, Martín NY, Lengefeld J.   +4 more
europepmc   +1 more source

Phase I/II Trial of StemRegenin-1 Expanded Umbilical Cord Blood Hematopoietic Stem Cells Supports Testing as a Stand-Alone Graft.

Cell Stem Cell, 2016
J. Wagner, C. Brunstein, Anthony E. Boitano, T. Defor, D. McKenna, D. Sumstad, B. Blazar, J. Tolar, C. Le, Julie Jones, M. Cooke, C. Bleul   +11 more
semanticscholar   +1 more source

Mechanisms of Pericyte‐Mediated Cancer Metastasis

Advanced Science, EarlyView.
Pericytes play multifarious roles in promoting cancer metastasis by facilitating metastatic cancer cell dissemination, circulating tumor cell survival, tissue extravasation, premetastatic niche formation, and metastatic tumor growth. These cells have intertwined interactions with vascular endothelial cells to modulate cancer cell behavior and ...
Ziheng Guo, Yihai Cao
wiley   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis.

Cell, 2009
S. Jaiswal, C. Jamieson, W. Pang, Christopher Y. Park, M. Chao, R. Majeti, D. Traver, Nico van Rooijen, I. Weissman   +8 more
semanticscholar   +1 more source

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

From bud to stem: dynamics of hematopoietic stem cells that drive homing and mobilization. [PDF]

Curr Opin Hematol
Razmkhah F, Hurwitz SN.
europepmc   +1 more source