Results 191 to 200 of about 1,207,844 (359)

CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages.

Cell Stem Cell, 2016
J. Hur, Jae-il Choi, H. Lee, Pniel Nham, Tae-Won Kim, Cheong-Whan Chae, J. Yun, Jin-A Kang, Jeehoon Kang, Sang Eun Lee, C. Yoon, Kyungjin Boo, Seokjin Ham, Tae-Young Roh, J. K. Jun, H. Lee, S. H. Baek, Hyo‐Soo Kim   +17 more
semanticscholar   +1 more source

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

CHEK2 loss endows chemotherapy resistance to hematopoietic stem cells. [PDF]

Leukemia
Zhou J, Hu T, Li D, Li S, Li M, Shi X, Nakada D.   +6 more
europepmc   +1 more source

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia.

Cell Stem Cell, 2016
N. Zambetti, Z. Ping, Si Chen, K. Kenswil, M. Mylona, M. Sanders, R. Hoogenboezem, E. Bindels, Maria N. Adisty, Paulina M. H. van Strien, Cindy S. van der Leije, T. Westers, E. Cremers, C. Milanese, P. Mastroberardino, J. V. van Leeuwen, Bram C. J. van der Eerden, I. Touw, T. Kuijpers, R. Kanaar, A. A. van de Loosdrecht, T. Vogl, M. Raaijmakers   +22 more
semanticscholar   +1 more source

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, EarlyView.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source

Cryopreservation and Thawing of <i>Ex Vivo</i> Expanded Cord Blood Hematopoietic Stem Cells. [PDF]

J Hematol
Morton L, Arulchelvam I, McGregor C, Ghannouchi L, Pineault N.   +4 more
europepmc   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

Ex Vivo Gene and Cell Therapy in Hematopoietic Stem Cells. [PDF]

Int J Mol Sci
Petrova IO, Smirnikhina SA.
europepmc   +1 more source

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

NCOA2 promotes the return of hematopoietic stem cells to quiescence after irradiation stress by regulating FOXO3a-dependent mitophagy. [PDF]

Hemasphere
Chen F, Chen N, Wang L, Zeng H, Lu Y, Liu Y, Chen J, Xu Y, Chen M, Wang S, Shen M, Wang J, Hu M.   +12 more
europepmc   +1 more source