Results 191 to 200 of about 224,203 (310)

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Prospective isolation of mouse and human hematopoietic stem cells using PLXDC2. [PDF]

Commun Biol
Tanaka Y, Kubota Y, Kikuchi R, Yabushita T, Kimura T, Lieberam I, Barlow JL, Bramley JW, Fukushima T, Sakuma C, Shibata T, Nakagawa M, Kurosawa Y, Maruyama T, Okumura CJ, Arima Y, Sato Y, Ono Y, Akuta T, Mizuno H, Kent DG, Jessell TM, Goyama S, Nishikii H, Kimura S, Yamazaki S, Suda T, Kitamura T.   +27 more
europepmc   +1 more source

Exploring individualized crovalimab dosing in PNH through in silico modelling: Potential for improved convenience and cost efficiency

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, acquired haematopoietic stem cell disorder. Crovalimab, a complement C5‐inhibitor, is approved for PNH and can be self‐administered subcutaneously every 4 weeks, offering a more convenient route than intravenous C5‐inhibitors.
Mendy ter Avest, Simon E. Koele, Nicole C. A. J. van de Kar, Saskia M. C. Langemeijer, Rob ter Heine   +4 more
wiley   +1 more source

Impact of Preanalytical Sample Preparation on the Recovery Rate of Cryopreserved Allogeneic Hematopoietic Stem Cells. [PDF]

Eur J Haematol
Blüm P, Glas C, Bieback K, Kayser S, Klüter H, Wuchter P.   +5 more
europepmc   +1 more source

Affinity Peptides With pH Sensitivity for the Enrichment of CD38+ Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The selective enrichment of cell populations based on surface markers is critical for the advancement of gene and cell therapies. Current antibody‐based cell isolation methods, such as fluorescence‐ and magnetic‐activated cell sorting (FACS and MACS), offer high specificity but are limited by scalability, cost, and potential adverse effects on
Gabrielle Rusch, Mickael Meyer, I. Mohamed Irfan, Carson Huber, Joseph Burclaff, Scott T. Magness, Stefano Menegatti, Michael Daniele   +7 more
wiley   +1 more source

Targeting RhoA nuclear mechanoactivity rejuvenates aged hematopoietic stem cells. [PDF]

Nat Aging
Mejía-Ramírez E, Picazo PI, Walter B, Montserrat-Vazquez S, Affuso F, Wieser S, Pezzano F, Reymond L, Castillo-Robles J, Matteini F, Mularoni L, Maciá D, Raya Á, Ruprecht V, Zheng Y, Petrone P, Florian MC.   +16 more
europepmc   +1 more source

Fouling‐Free Inertial Microfluidic Cell Clarification for Lentivirus Manufacturing

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Lentiviral vectors (LVVs) are widely used as gene‐delivery vehicles in cell and gene therapy, enabling stable integration of transgenes into target cells. However, efficient clarification of LVV harvest remains a major bottleneck in large‐scale manufacturing, as conventional depth filtration often results in significant product loss.
Dohyun Park, Alexander Bevacqua, Mingyang Cui, Marina Nichols, Jianzhu Chen, Jongyoon Han   +5 more
wiley   +1 more source

Hematopoietic stem cells biology and transplantation , [this volume contains the papers from a conference entitled "Hematopoietic stem cells II: international symposium and workshop", which was hosted by the University of Tübingen in Meersburg, Germany on July 1 - 4, 1998]

, 1999
Conference Entitled Hematopoietic Stem Cells 1998 Meersburg, Orlic, Donald   +1 more
core  

In vivo modeling of stress erythropoiesis through targeted gene editing of rat hematopoietic stem cells. [PDF]

Blood Adv
van der Meulen SA, Roemhild K, Driessen M, van den Akker E, Nethe M.   +4 more
europepmc   +1 more source

Metal-Free Induced Tandem Cyclization of 2‑Aryl‑N‑Methacryloyl Indoles via 1,2-Hydrogen Atom Transfer

ACS Omega
Peng Chen, Wanting Peng, Xingqin Tian, Shuying Li, Fang Ye, Guanghui Lv   +5 more
doaj   +1 more source