Results 211 to 220 of about 1,207,844 (359)

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

In vivo modeling of stress erythropoiesis through targeted gene editing of rat hematopoietic stem cells. [PDF]

Blood Adv
van der Meulen SA, Roemhild K, Driessen M, van den Akker E, Nethe M.   +4 more
europepmc   +1 more source

Sound‐Based Assembly of Magnetically Actuated Soft Robots Toward Enhanced Release of Extracellular Vesicles

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Magnetic soft robots offer promise in biomedicine due to their wireless actuation and rapid response, but current fabrication methods are complex and have limited cellular compatibility. A new, contactless bioassembly strategy using hydrodynamic instabilities is introduced, enabling customizable, centimeter‐scale robots.
Wei Gao, Riccardo Tognato, Micaela Natta, Elena Della Bella, Alessandro Cianciosi, Tiziano Serra   +5 more
wiley   +1 more source

Engraftment Outcome of CRISPR/Cas9-Edited Hematopoietic Stem Cells for Genetic Diseases: A Systematic Review and Meta-Analysis of Preclinical Evidence. [PDF]

J Hematol
Yadav S, Chakravarti B, Anjum B, Yadav S, Singh PK, Kumar A.   +5 more
europepmc   +1 more source

Hematopoietic stem cells: concepts, definitions, and the new reality.

Blood, 2015
C. Eaves
semanticscholar   +1 more source

Natural History of Chronic Kidney Disease in Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Kidney complications, referred to as nephropathy, develop early in sickle cell disease (SCD). In addition to its known morbidity, abundant data show that chronic kidney disease (CKD) is associated with an increased mortality risk in SCD. Increasing evidence suggests that the natural history of SCD nephropathy is progressive. Initial glomerular
Kenneth I. Ataga
wiley   +1 more source

Mesenchymal stromal cells modulate survival and regeneration of human hematopoietic stem cells via PGE2/cAMP signaling. [PDF]

Cell Death Dis
Muddineni SSNA, Katz-Even C, Zipin-Roitman A, Rasoulouniriana D, Singha Roy D, Aborgies R, Beider K, Raz Y, Solomon N, Hershkovitz G, Shulman Y, Chen R, Weizman E, Waskow C, Nagler A, Milyavsky M.   +15 more
europepmc   +1 more source

TGF-β signaling in the control of hematopoietic stem cells.

Blood, 2015
Ulrika Blank, S. Karlsson
semanticscholar   +1 more source

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, EarlyView.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source

Engraftment of gene-edited hematopoietic stem cells after antibody-drug conjugate conditioning in nonhuman primates. [PDF]

Blood Adv
Murray J, Einhaus T, Radtke S, Bar KJ, Peterson CW, Kiem HP.   +5 more
europepmc   +1 more source