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Targeting RhoA activity rejuvenates aged hematopoietic stem cells
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Hematopoietic Stem Cells and Regeneration
Cold Spring Harbor Perspectives in Biology, 2021Hematopoietic stem cell (HSC) regeneration is the remarkable process by which extremely rare, normally inactive cells of the bone marrow can replace an entire organ if called to do so by injury or harnessed by transplantation. HSC research is arguably the first quantitative single-cell science and the foundation of adult stem cell biology.
Mitch, Biermann, Tannishtha, Reya
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Making a Hematopoietic Stem Cell [PDF]
Trends in Cell Biology, 2016 Previous attempts to either generate or expand hematopoietic stem cells (HSCs) in vitro have involved either ex vivo expansion of pre-existing patient or donor HSCs or de novo generation from pluripotent stem cells (PSCs), comprising both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
Michael G Daniel +2 more
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New England Journal of Medicine, 1979
(First of Three Parts) IN man, most tissues consist primarily of differentiated cells that normally show little evidence of proliferation and self-renewal.
P, Quesenberry, L, Levitt
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(First of Three Parts) IN man, most tissues consist primarily of differentiated cells that normally show little evidence of proliferation and self-renewal.
P, Quesenberry, L, Levitt
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Cancer Investigation, 2002
In the broadest sense, stem cells are primitive cells endowed with extensive capacities to develop and differentiate into functional and mature tissues or organs.
Paul, Schwarzenberger +2 more
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In the broadest sense, stem cells are primitive cells endowed with extensive capacities to develop and differentiate into functional and mature tissues or organs.
Paul, Schwarzenberger +2 more
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Clinical Orthopaedics and Related Research, 2000
Hematopoietic stem cells are rare cells found in the bone marrow, peripheral blood, placenta, and elsewhere that sustain the hematopoietic system. The current review will focus on the evolving views of the biology of these cells. Because hematopoietic stem cells have been studied and transplanted for several decades, lessons learned from studying these
C, Smith, B, Storms
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Hematopoietic stem cells are rare cells found in the bone marrow, peripheral blood, placenta, and elsewhere that sustain the hematopoietic system. The current review will focus on the evolving views of the biology of these cells. Because hematopoietic stem cells have been studied and transplanted for several decades, lessons learned from studying these
C, Smith, B, Storms
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Pediatrics, 2004
The hematopoietic system of the young child acquires, through time, the ability to cope with exposure to a number of environmental toxins and infectious agents. Occasionally, severe aplastic anemia occurs secondary to exposure to some of these toxins or infectious agents.
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The hematopoietic system of the young child acquires, through time, the ability to cope with exposure to a number of environmental toxins and infectious agents. Occasionally, severe aplastic anemia occurs secondary to exposure to some of these toxins or infectious agents.
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2013
Hematopoietic stem cells represent the most studied and understood adult stem cell, and have consequently set the trends for the investigation of a wide array of stem cells, while their clinical use for over half a century and ever improving efficacy encourages the view that stem cell therapy will 1 day be useful in the treatment of a whole host of ...
Mary L. Clarke, Jonathan Frampton
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Hematopoietic stem cells represent the most studied and understood adult stem cell, and have consequently set the trends for the investigation of a wide array of stem cells, while their clinical use for over half a century and ever improving efficacy encourages the view that stem cell therapy will 1 day be useful in the treatment of a whole host of ...
Mary L. Clarke, Jonathan Frampton
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Current Biology, 1992
Recent studies indicate that hematopoietic stem cells that provide long-term reconstitution can be separated from more mature hematopoietic cells that provide radioprotection and short-term repopulation. With these findings it is now possible to design assays that will specifically measure long-term repopulating stem cells, as well as to develop ...
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Recent studies indicate that hematopoietic stem cells that provide long-term reconstitution can be separated from more mature hematopoietic cells that provide radioprotection and short-term repopulation. With these findings it is now possible to design assays that will specifically measure long-term repopulating stem cells, as well as to develop ...
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The aging of hematopoietic stem cells
Nature Medicine, 1996We have purified hematopoietic stem cells (HSCs) from the bone marrow of old mice and compared their properties to HSCs in young and middle-aged mice. Single, reconstituting HSCs (by limit dilution) from old and young mice exhibited indistinguishable progenitor activities in vivo. HSCs were five times as frequent in the bone marrow of old mice; however,
S J, Morrison +4 more
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